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TRIO [cytosol]
Stable Identifier
R-HSA-2980605
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Triple functional domain protein ecNumber2.7.11.1/ecNumber, TRIO_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
Activation of Cdc42 (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Activation of Rac1 (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Recruitment of ABLIM to the plasma membrane (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP:ABLIM [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RhoGTPase GEF's recruited to DCC (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GEFs activate RAC3 (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GEFs activate RHOG (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GEFs activate RHOJ (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
TRIO [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75962 TRIO
Gene Names
TRIO
Chain
chain:1-3097
Reference Genes
BioGPS Gene:7204 TRIO
COSMIC (genes):TRIO TRIO
CTD Gene:7204 TRIO
dbSNP Gene:7204 TRIO
ENSEMBL:ENSG00000038382 TRIO
HGNC:12303 TRIO
KEGG:hsa:7204 TRIO
Monarch:7204 TRIO
NCBI Gene:7204 TRIO
OMIM:601893 TRIO
UCSC:O75962 TRIO
Reference Transcript
RefSeq:XM_011514110.2 TRIO
RefSeq:NM_007118.3 TRIO
Other Identifiers
11724260_a_at
11724261_a_at
11724262_s_at
11744590_a_at
11759631_at
11761938_a_at
16983286
208178_PM_x_at
208178_x_at
209010_PM_s_at
209010_s_at
209011_PM_at
209011_at
209012_PM_at
209012_at
209013_PM_x_at
209013_x_at
216697_3p_at
216697_PM_at
216697_at
231403_PM_at
231403_at
2802399
2802400
2802450
2802451
2802454
2802455
2802456
2802461
2802462
2802463
2802466
2802467
2802472
2802473
2802477
2802484
2802491
2802496
2802504
2802505
2802506
2802507
2802510
2802511
2802512
2802513
2802514
2802516
2802517
2802518
2802519
2802521
2802522
2802523
2802524
2802525
2802526
2802527
2802529
2802530
2802531
2802534
2802535
2802536
2802537
2802538
2802539
2802540
2802541
2802545
2802546
2802563
2802564
2802565
2802567
2802568
2802582
2802583
2802584
2802585
2802586
2802587
2802588
2802589
2802590
2802591
2802592
2802596
2802597
2802598
2802600
2802601
2802602
2802604
2802606
2802609
2802610
2802611
2802612
2802614
2802617
2802618
2802619
2802620
2802621
2802622
2802623
2802624
2802625
2802629
2802631
2802632
2802633
2802634
2802635
2802636
2802637
2802638
2802639
2802640
2802641
2802642
2802647
2802650
2802651
2802653
2802655
2802656
2802657
2802658
2802659
2802661
2802663
40581_at
40792_s_at
42354_at
48936_at
56885_at
7204
8104506
91496_at
A_23_P425880
A_24_P42603
A_24_P913431
A_33_P3415500
GE54768
GE719636
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005085
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006468
GO:0007185
GO:0007411
GO:0016740
GO:0019898
GO:0042995
GO:0045599
GO:0048786
GO:0048812
GO:0051056
GO:0098772
GO:0098794
GO:0098978
GO:0099170
GO:0106310
GO:0140096
HMNXSV003044697
HMNXSV003049649
Hs.108514.0.A1_3p_at
Hs.171957.1.A1_3p_a_at
Hs.171957.1.A3_3p_at
Hs.171957.1.A4_3p_at
Hs.306491.0.S1_3p_at
Hs.306491.0.S1_3p_x_at
ILMN_1805792
PH_hs_0006060
PH_hs_0017511
TC05000083.hg
TC05002283.hg
U42390_at
g3644047_3p_a_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
DOCK1,TRIO [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
Inferred To
Dmel\CG15611 [cytosol]
(Drosophila melanogaster)
CG15612 [cytosol]
(Drosophila melanogaster)
trio [cytosol]
(Drosophila melanogaster)
TRIO [cytosol]
(Bos taurus)
TRIO [cytosol]
(Danio rerio)
TRIO [cytosol]
(Gallus gallus)
TRIO [cytosol]
(Mus musculus)
TRIO [cytosol]
(Rattus norvegicus)
TRIO [cytosol]
(Sus scrofa)
Homologues of TRIO [cytosol]
(Drosophila melanogaster)
unc-73 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_009049.2
,
XP_011512412.1
Guide to Pharmacology - Targets
2255
ENSEMBL
ENST00000344204
,
ENSP00000339299
OpenTargets
ENSG00000038382
HPA
ENSG00000038382-TRIO
PRO
O75962
Pharos - Targets
O75962
Orphanet
TRIO
HMDB Protein
HMDBP08613
PDB
1NTY
,
7SJ4
,
6D8Z
,
2NZ8
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.553
2
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