Reactome | CLTCL1 [lysosomal membrane]

CLTCL1 [lysosomal membrane]

Stable Identifier

R-HSA-2980658

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Clathrin heavy chain 2, CLH2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction degradation (Homo sapiens)
        
        Internalization of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        Clathrin [lysosomal membrane] (Homo sapiens)
        
        Clathrin heavy chain [lysosomal membrane] (Homo sapiens)
        
        CLTCL1 [lysosomal membrane] (Homo sapiens)
        
        Lysosomal degradation of gap junction plaques (Homo sapiens)
        
        Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Homo sapiens)
        
        junctional plaque prior to invagination [lysosomal membrane] (Homo sapiens)
        
        Clathrin [lysosomal membrane] (Homo sapiens)
        
        Clathrin heavy chain [lysosomal membrane] (Homo sapiens)
        
        CLTCL1 [lysosomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53675 CLTCL1

Gene Names

CLTCL1, CLH22, CLTCL, CLTD

Chain

initiator methionine:, chain:2-1640

Reference Genes

BioGPS Gene:8218 CLTCL1

COSMIC (genes):CLTCL1 CLTCL1

CTD Gene:8218 CLTCL1

dbSNP Gene:8218 CLTCL1

ENSEMBL:ENSG00000070371 CLTCL1

HGNC:2093 CLTCL1

KEGG:hsa:8218 CLTCL1

Monarch:8218 CLTCL1

NCBI Gene:8218 CLTCL1

OMIM:601273 CLTCL1

UCSC:P53675 CLTCL1

Reference Transcript

Other Identifiers

11724989_a_at

11724990_s_at

11750172_a_at

11750173_x_at

16932217

205944_PM_s_at

205944_s_at

33330_at

3952561

3952562

3952563

3952564

3952565

3952567

3952568

3952569

3952570

3952571

3952572

3952573

3952574

3952575

3952576

3952582

3952583

3952584

3952585

3952586

3952587

3952588

3952589

3952591

3952592

3952595

3952596

3952597

3952600

3952601

3952603

3952604

3952605

3952606

3952607

3952608

3952609

3952610

3952611

3952612

3952613

3952614

3952615

3952616

3952617

3952619

3952624

3952626

3952627

3952630

3952631

3952632

8074399

8218

A_23_P143559

GE62763

GE85264

GO:0000278

GO:0005198

GO:0005515

GO:0005768

GO:0005770

GO:0005802

GO:0005819

GO:0005829

GO:0005905

GO:0006886

GO:0006898

GO:0009653

GO:0012505

GO:0016020

GO:0016192

GO:0030130

GO:0030132

GO:0030135

GO:0030136

GO:0030659

GO:0031410

GO:0032051

GO:0042147

GO:0043226

GO:0045334

GO:0046326

GO:0070062

GO:0071439

GO:0097443

HMNXSV003011237

HMNXSV003024346

HMNXSV003033948

ILMN_1694584

ILMN_1739734

PH_hs_0010879

TC22000487.hg

U41763_at

g9257201_3p_a_at

Participates

as a candidate of

Clathrin heavy chain [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

CLTCL1 [cytosol]

CLTCL1 [plasma membrane]

Inferred To

CLTCL1 [lysosomal membrane] (Canis familiaris)

CLTCL1 [lysosomal membrane] (Gallus gallus)

Chc [lysosomal membrane] (Drosophila melanogaster)

chc-1 [lysosomal membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENSP00000485020, ENSP00000441158, ENST00000621271, ENST00000427926, ENSG00000070371

OpenTargets

ENSG00000070371

GeneCards

CLTCL1

HPA

ENSG00000070371-CLTCL1

PRO

P53675

Pharos - Targets

P53675

GlyGen

P53675

Orphanet

CLTCL1

HMDB Protein

HMDBP07613

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	8