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DAB2 [plasma membrane]
Stable Identifier
R-HSA-2980808
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Disabled homolog 2, DAB2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Formation of annular gap junctions (Homo sapiens)
Dab2 is recruited to the junctional plaques (Homo sapiens)
DAB2 [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
DAB2 [plasma membrane] (Homo sapiens)
Dynamin is recruited to the gap junction plaque (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
DAB2 [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
DAB2 [plasma membrane] (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
DAB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98082 DAB2
Gene Names
DAB2, DOC2
Chain
initiator methionine:, chain:2-770
Reference Genes
BioGPS Gene:1601 DAB2
COSMIC (genes):DAB2 DAB2
CTD Gene:1601 DAB2
dbSNP Gene:1601 DAB2
ENSEMBL:ENSG00000153071 DAB2
ENSEMBL_homo_sapiens_GENE:ENSG00000153071.15 DAB2
HGNC:2662 DAB2
KEGG Gene (Homo sapiens):1601 DAB2
Monarch:1601 DAB2
NCBI Gene:1601 DAB2
OMIM:601236 DAB2
UCSC:P98082 DAB2
Reference Transcript
RefSeq:NM_001343.3 DAB2
RefSeq:NM_001244871.1 DAB2
Other Identifiers
11722355_s_at
11722356_a_at
11744796_a_at
11744797_s_at
1601
16995645
201278_PM_at
201278_at
201279_PM_s_at
201279_s_at
201280_PM_s_at
201280_s_at
210757_PM_x_at
210757_x_at
2854443
2854444
2854446
2854447
2854448
2854449
2854453
2854455
2854457
2854458
2854459
2854463
2854464
2854465
2854471
2854472
2854479
2854480
2854483
2854485
2854488
2854489
2854490
2854491
2854492
2854508
45341_at
479_at
51367_at
8111772
A_23_P257871
A_32_P183047
A_33_P3338928
GE59240
GO:0000122
GO:0001650
GO:0001934
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0005925
GO:0006351
GO:0006355
GO:0006629
GO:0006897
GO:0006898
GO:0006915
GO:0007155
GO:0007179
GO:0010718
GO:0010977
GO:0012501
GO:0015031
GO:0016020
GO:0016055
GO:0016192
GO:0023052
GO:0030136
GO:0030154
GO:0030163
GO:0030308
GO:0030335
GO:0030665
GO:0031410
GO:0032091
GO:0032349
GO:0032436
GO:0035026
GO:0035615
GO:0036211
GO:0038024
GO:0043066
GO:0043226
GO:0043231
GO:0045807
GO:0045944
GO:0046332
GO:0048268
GO:0048471
GO:0048545
GO:0048856
GO:0048870
GO:0050680
GO:0050750
GO:0050886
GO:0060090
GO:0060391
GO:0060766
GO:0065003
GO:0070373
GO:0071364
GO:0071560
GO:0072659
GO:0090090
GO:1900026
GO:1902074
GO:1903077
GO:2000096
GO:2000370
GO:2000643
GO:2000860
HMNXSV003046451
Hs.81988.0.S3_3p_at
ILMN_1764228
ILMN_2128428
PH_hs_0027712
TC05002969.hg
TC05003425.hg
U53446_at
g13111753_3p_a_at
g4503250_3p_a_at
Participates
as an input of
Dab2 is recruited to the junctional plaques (Homo sapiens)
as a component of
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
DAB2 [cytosol]
DAB2 [lysosomal membrane]
Inferred To
Dab2 [plasma membrane]
(Mus musculus)
Dab2 [plasma membrane]
(Rattus norvegicus)
Ghost homologue of DAB2 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of DAB2 [plasma membrane]
(Dictyostelium discoideum)
Ghost homologue of DAB2 [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of DAB2 [plasma membrane]
(Saccharomyces cerevisiae)
Ghost homologue of DAB2 [plasma membrane]
(Schizosaccharomyces pombe)
dab2 [plasma membrane]
(Xenopus tropicalis)
DAB2 [plasma membrane]
(Bos taurus)
DAB2 [plasma membrane]
(Canis familiaris)
DAB2 [plasma membrane]
(Gallus gallus)
DAB2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001231800.1
,
NP_001334.2
OpenTargets
ENSG00000153071
GeneCards
P98082
HPA
ENSG00000153071-DAB2
Ensembl
ENSP00000345508
,
ENST00000509337
,
ENST00000320816
,
ENSG00000153071
,
ENSP00000313391
,
ENSP00000439919
,
ENST00000339788
,
ENST00000545653
,
ENSP00000426245
PRO
P98082
Pharos - Targets
P98082
PDB
6OVF
,
6O5O
,
2LSW
HMDB Protein
HMDBP14533
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.573
2
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UM54 MYO6
3
MYO6 [plasma membrane]
(R-HSA-3006691)
MYO6 [lysosomal membrane]
(R-HSA-3006694)
MYO6 [cytosol]
(R-HSA-3006692)
0.543
3
UniProt:Q8N5S1 S2541
0.527
2
UniProt:Q0JRZ9 FCHO2
1
FCHO2 [cytosol]
(R-HSA-8862260)
0.527
3
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.524
20
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
4
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.524
3
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