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p-S206-NEK6 [cytosol]
Stable Identifier
R-HSA-2984253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S206-Serine/threonine-protein kinase Nek6, p-S206-NimA-related protein kinase 6
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 binds to microtubules (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Homo sapiens)
NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
p-S206-NEK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HC98 NEK6
Gene Names
NEK6
Chain
chain:1-313
Reference Genes
BioGPS Gene:10783 NEK6
COSMIC (genes):NEK6 NEK6
CTD Gene:10783 NEK6
dbSNP Gene:10783 NEK6
ENSEMBL:ENSG00000119408 NEK6
ENSEMBL_homo_sapiens_GENE:ENSG00000119408.17 NEK6
HGNC:7749 NEK6
KEGG Gene (Homo sapiens):10783 NEK6
Monarch:10783 NEK6
NCBI Gene:10783 NEK6
OMIM:604884 NEK6
UCSC:Q9HC98 NEK6
Reference Transcript
RefSeq:NM_001166168.1 NEK6
RefSeq:XM_017014217.1 NEK6
RefSeq:NM_001166169.1 NEK6
RefSeq:NM_014397.5 NEK6
RefSeq:NM_001145001.2 NEK6
RefSeq:XM_005251664.1 NEK6
RefSeq:NM_001166167.1 NEK6
RefSeq:NM_001166170.1 NEK6
RefSeq:NM_001166171.1 NEK6
RefSeq:XM_006716936.2 NEK6
Other Identifiers
10783
11724820_a_at
11724821_a_at
11725182_a_at
11753405_a_at
17088929
223158_PM_s_at
223158_s_at
223159_PM_s_at
223159_s_at
244823_PM_at
244823_at
3188698
3188699
3188700
3188715
3188716
3188719
3188720
3188730
3188731
3188732
3188733
3188734
3188742
3188748
3188749
3188750
3188751
3188752
3188753
3188754
58695_at
8157761
A_23_P216920
GE53676
GO:0000166
GO:0000278
GO:0000287
GO:0000922
GO:0001222
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0006468
GO:0006915
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0007077
GO:0007346
GO:0008092
GO:0012501
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0019894
GO:0019901
GO:0023052
GO:0030071
GO:0031625
GO:0032991
GO:0034451
GO:0036211
GO:0043123
GO:0043226
GO:0046777
GO:0046872
GO:0051225
GO:0051301
GO:0061024
GO:0106310
GO:0140096
GO:0140297
GO:2000772
HMNXSV003032140
Hs.323245.0.S1_3p_at
Hs.9625.2.S1_3p_a_at
ILMN_1660871
PH_hs_0024415
TC09000634.hg
g12652704_3p_a_at
Participates
as a member of
p-S206-NEK6/p-S195-NEK7 [cytosol] (Homo sapiens)
Other forms of this molecule
NEK6 [cytosol]
Inferred To
phospho-p-S206-NEK6 [cytosol]
(Caenorhabditis elegans)
phospho-p-S206-NEK6 [cytosol]
(Canis familiaris)
phospho-p-S206-NEK6 [cytosol]
(Gallus gallus)
phospho-p-S206-NEK6 [cytosol]
(Sus scrofa)
phospho-NEK6 [cytosol]
(Bos taurus)
Modified Residues
Name
O-phospho-L-serine at 206
Coordinate
206
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_006716999.1
,
NP_001159640.1
,
NP_055212.2
,
NP_001159642.1
,
NP_001138473.1
,
XP_016869706.1
,
NP_001159639.1
,
XP_005251721.1
,
NP_001159641.1
,
NP_001159643.1
ZINC - World Drugs
NEK6_HUMAN
Guide to Pharmacology - Targets
2121
OpenTargets
ENSG00000119408
ZINC - Substances
NEK6_HUMAN
ZINC target
Q9HC98
ZINC - Biogenic
NEK6_HUMAN
PRO
Q9HC98
ZINC - Investigational
NEK6_HUMAN
ZINC - Metabolites
NEK6_HUMAN
HPA
ENSG00000119408-NEK6
GeneCards
Q9HC98
Ensembl
ENSG00000119408
,
ENST00000546191
,
ENSP00000362705
,
ENST00000373600
,
ENST00000545174
,
ENST00000394199
,
ENSP00000319734
,
ENSP00000377749
,
ENST00000320246
,
ENST00000373603
,
ENST00000540326
,
ENSP00000442636
,
ENST00000539416
,
ENSP00000441426
,
ENSP00000439651
,
ENSP00000362702
,
ENSP00000441469
Pharos - Targets
Q9HC98
ZINC - Predictions - Purchasable
NEK6_HUMAN
HMDB Protein
HMDBP01264
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.666
4
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.556
3
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
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