Reactome | SENP5 [nucleoplasm]

SENP5 [nucleoplasm]

Stable Identifier

R-HSA-2984297

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Sentrin-specific protease 5 ecNumber3.4.22.68/ecNumber, SENP5_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Yeh, ET, Gong, L	J. Biol. Chem.	2006

External Reference Information

External Reference

UniProt:Q96HI0 SENP5

Gene Names

SENP5, FKSG45

Chain

chain:1-755

Reference Genes

BioGPS Gene:205564 SENP5

COSMIC (genes):SENP5 SENP5

CTD Gene:205564 SENP5

dbSNP Gene:205564 SENP5

ENSEMBL:ENSG00000119231 SENP5

HGNC:28407 SENP5

KEGG:hsa:205564 SENP5

Monarch:205564 SENP5

NCBI Gene:205564 SENP5

OMIM:612845 SENP5

UCSC:Q96HI0 SENP5

Reference Transcript

Other Identifiers

11721920_at

11721921_at

11752237_a_at

16950035

205564

213184_PM_at

213184_at

222110_PM_at

222110_at

2659632

2659633

2659636

2659637

2659638

2659639

2659643

2659644

2659645

2659646

2659647

2659653

2659655

2659657

2659658

2659660

2659661

2659662

2659668

2659669

2659670

2659671

2659673

2659675

32082_at

44188_at

4852000C_3p_s_at

50755_at

57703_PM_at

57703_at

8084971

A_14_P115220

A_14_P135486

A_23_P18102

A_23_P29504

A_32_P114447

A_32_P32653

GE56140

GE79883

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0006508

GO:0008234

GO:0016787

GO:0016925

GO:0016926

GO:0016929

GO:0043226

GO:0051301

GO:0070139

GO:0099523

GO:0099524

GO:0140096

HMNXSV003031212

Hs.13138.0.S1_3p_at

Hs.15787.0.S1_3p_at

ILMN_1675501

PH_hs_0001262

TC03001101.hg

Participates

as a member of

SENP1,2,5 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of SENP5 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SENP5 [nucleoplasm] (Drosophila melanogaster)

Homologues of SENP5 [nucleoplasm] (Saccharomyces cerevisiae)

Dmel\CG32110 [nucleoplasm] (Drosophila melanogaster)

ULP1 [nucleoplasm] (Saccharomyces cerevisiae)

Ulp1 [nucleoplasm] (Drosophila melanogaster)

ulp-1 [nucleoplasm] (Caenorhabditis elegans)

ulp-5 [nucleoplasm] (Caenorhabditis elegans)

ulp1 [nucleoplasm] (Schizosaccharomyces pombe)

Senp5 [nucleoplasm] (Mus musculus)

Senp5l1 [nucleoplasm] (Rattus norvegicus)

SENP5 [nucleoplasm] (Bos taurus)

SENP5 [nucleoplasm] (Canis familiaris)

SENP5 [nucleoplasm] (Dictyostelium discoideum)

SENP5 [nucleoplasm] (Gallus gallus)

SENP5 [nucleoplasm] (Plasmodium falciparum)

SENP5 [nucleoplasm] (Sus scrofa)

ulp-2 [nucleoplasm] (Caenorhabditis elegans)

ULP2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_011510846.1, NP_001294974.1, XP_016861359.1, NP_689912.2

ENSEMBL

ENST00000445299, ENSP00000327197, ENST00000323460, ENSP00000390231

OpenTargets

ENSG00000119231

HPA

ENSG00000119231-SENP5

PRO

Q96HI0

Pharos - Targets

Q96HI0

GlyGen

Q96HI0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	3

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