Reactome | SENP2 [nucleoplasm]

SENP2 [nucleoplasm]

Stable Identifier

R-HSA-2984298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Sentrin-specific protease 2 ecNumber3.4.22.68/ecNumber, SENP2_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
12192048	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex Zhang, H, Matunis, MJ, Saitoh, H	Mol. Cell. Biol.	2002

External Reference Information

External Reference

UniProt:Q9HC62 SENP2

Gene Names

SENP2, KIAA1331

Chain

chain:1-589

Reference Genes

BioGPS Gene:59343 SENP2

COSMIC (genes):SENP2 SENP2

CTD Gene:59343 SENP2

dbSNP Gene:59343 SENP2

ENSEMBL:ENSG00000163904 SENP2

HGNC:23116 SENP2

KEGG:hsa:59343 SENP2

Monarch:59343 SENP2

NCBI Gene:59343 SENP2

OMIM:608261 SENP2

UCSC:Q9HC62 SENP2

Reference Transcript

RefSeq:NM_021627.2 SENP2

Other Identifiers

11720485_s_at

11720486_a_at

11747578_a_at

11747579_x_at

16949214

218122_PM_s_at

218122_s_at

222523_PM_at

222523_at

228380_PM_at

228380_at

2656242

2656243

2656245

2656246

2656247

2656248

2656252

2656253

2656254

2656256

2656257

2656258

2656259

2656260

2656261

2656262

2656263

2656264

2656265

2656266

2656267

2656268

2656269

2656270

2656271

2656272

2656274

2656275

2656276

2656277

2656283

2656284

2656286

2656288

2656291

2656293

2656294

54618_at

55041_at

59343

8084607

88031_at

A_14_P135670

A_32_P420000

A_32_P74712

GE695468

GO:0003824

GO:0005515

GO:0005634

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0008234

GO:0015031

GO:0016020

GO:0016055

GO:0016605

GO:0016787

GO:0016925

GO:0016926

GO:0016929

GO:0030111

GO:0030154

GO:0031397

GO:0031398

GO:0031648

GO:0031965

GO:0043226

GO:0045444

GO:0051028

GO:0070139

GO:0140096

HMNXSV003030257

Hs.3355.0.S2_3p_at

Hs.86945.0.A1_3p_at

ILMN_1801121

ILMN_2123567

PH_hs_0033121

TC03001012.hg

g11055993_3p_a_at

Participates

as a member of

SENP1,2,5 [nucleoplasm] (Homo sapiens)

Inferred To

Dmel\CG32110 [nucleoplasm] (Drosophila melanogaster)

ULP1 [nucleoplasm] (Saccharomyces cerevisiae)

Ulp1 [nucleoplasm] (Drosophila melanogaster)

ulp-1 [nucleoplasm] (Caenorhabditis elegans)

ulp-5 [nucleoplasm] (Caenorhabditis elegans)

SENP2 [nucleoplasm] (Bos taurus)

SENP2 [nucleoplasm] (Canis familiaris)

SENP2 [nucleoplasm] (Dictyostelium discoideum)

SENP2 [nucleoplasm] (Gallus gallus)

SENP2 [nucleoplasm] (Plasmodium falciparum)

SENP2 [nucleoplasm] (Sus scrofa)

ulp1 [nucleoplasm] (Schizosaccharomyces pombe)

Senp2 [nucleoplasm] (Mus musculus)

Senp2 [nucleoplasm] (Rattus norvegicus)

ulp-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SENP2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SENP2 [nucleoplasm] (Drosophila melanogaster)

Homologues of SENP2 [nucleoplasm] (Saccharomyces cerevisiae)

ULP2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_067640.2

ENSEMBL

ENST00000296257, ENSP00000296257

OpenTargets

ENSG00000163904

HPA

ENSG00000163904-SENP2

PRO

Q9HC62

Pharos - Targets

Q9HC62

PDB

5AEK, 2IO2, 2IO0, 2IO3, 2IO1, 1TH0, 3ZO5, 1TGZ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55854 SUMO3	5	UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) SUMO3 [nucleoplasm] (R-HSA-2984269) lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830)	0.799	7
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.719	5
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.623	2
UniProt:P46060 RANGAP1	3	RANGAP1 [cytosol] (R-HSA-376255) RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416)	0.591	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.581	3
UniProt:P55056 APOC4	1	APOC4 [extracellular region] (R-HSA-5215930)	0.556	3
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.556	3
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.556	3
UniProt:P53701 HCCS	1	HCCS [mitochondrial inner membrane] (R-HSA-9866218)	0.556	3
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3

Cite Us!