SENP1,2,5 proteolytically process SUMO2

Stable Identifier
Reaction [transition]
Homo sapiens
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The SUMO2 precursor has 2 extra residues at the C-terminus which can be removed endoproteolytically by SENP1, SENP2, or SENP5 (Zheng and Au, 2005, Gong and Yeh 2006, Mikolajczyk et al. 2007). The order of processing activity is: SENP1 greater than SENP2 greater than SENP5 (Mikolajczyk et al. 2007). SENP2 and SENP5 have highest activity on SUMO2, however the processing activity of SENP1 is higher overall (Mikolajczyk et al. 2007). SENP1 and SENP2 shuttle between the nucleus and cytosol and are predominantly nuclear (Bailey and O'Hare 2004, Kim et al. 2005, Zhang et al. 2002, Hang and Dasso 2002, Itahana et al. 2006). SENP5 is located in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

Literature References
PubMed ID Title Journal Year
14563852 Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1

Bailey, D, O'Hare, P

J. Biol. Chem. 2004
17591783 Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs

Mikolajczyk, J, Drag, M, Békés, M, Cao, JT, Ronai, Z, Salvesen, GS

J. Biol. Chem. 2007
12192048 Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex

Zhang, H, Saitoh, H, Matunis, MJ

Mol. Cell. Biol. 2002
16608850 Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3

Gong, L, Yeh, ET

J. Biol. Chem. 2006
16738315 The SUMO-specific protease SENP5 is required for cell division

Di Bacco, A, Ouyang, J, Lee, HY, Catic, A, Ploegh, H, Gill, G

Mol. Cell. Biol. 2006
16253240 Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1

Kim, YH, Sung, KS, Lee, SJ, Kim, YO, Choi, CY, Kim, Y

FEBS Lett. 2005
16738331 Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2

Itahana, Y, Yeh, ET, Zhang, Y

Mol. Cell. Biol. 2006
11896061 Association of the human SUMO-1 protease SENP2 with the nuclear pore

Hang, J, Dasso, M

J. Biol. Chem. 2002
15487983 Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1

Xu, Z, Au, SW

Biochem. J. 2005
Catalyst Activity

SUMO-specific endopeptidase activity of SENP1,2,5 [nucleoplasm]

Orthologous Events
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