Reactome | NSMCE4A [nucleoplasm]

NSMCE4A [nucleoplasm]

Stable Identifier

R-HSA-2993757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Non-structural maintenance of chromosomes element 4 homolog A, NSE4A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
        
        SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
        
        EID3,NSMCE4A [nucleoplasm] (Homo sapiens)
        
        NSMCE4A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NXX6 NSMCE4A

Gene Names

NSMCE4A, C10orf86, PP4762

Chain

chain:1-385

Reference Genes

BioGPS Gene:54780 NSMCE4A

COSMIC (genes):NSMCE4A NSMCE4A

CTD Gene:54780 NSMCE4A

dbSNP Gene:54780 NSMCE4A

ENSEMBL:ENSG00000107672 NSMCE4A

HGNC:25935 NSMCE4A

Monarch:54780 NSMCE4A

NCBI Gene:54780 NSMCE4A

OMIM:612987 NSMCE4A

UCSC:Q9NXX6 NSMCE4A

Reference Transcript

Other Identifiers

11747082_x_at

11747840_x_at

11749033_x_at

11756175_a_at

11756424_a_at

11760740_a_at

16719088

211376_3p_s_at

211376_PM_s_at

211376_s_at

219067_PM_s_at

219067_s_at

228506_PM_at

228506_at

3310478

3310480

3310481

3310484

3310485

3310486

3310487

3310488

3310489

3310490

3310491

3310492

3310493

3310494

3310495

3310497

3310498

3310499

3310500

3310501

3310502

3310503

3310504

3310505

3310506

3310507

3310508

45762_at

54780

7936777

A_23_P75204

A_24_P189458

GE82182

GO:0000724

GO:0000781

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006310

GO:0006325

GO:0006974

GO:0016604

GO:0016925

GO:0030915

GO:0032204

GO:0032991

GO:0043226

GO:0043232

GO:0140588

HMNXSV003006778

HMNXSV003016265

Hs.258798.3.S1_3p_x_at

ILMN_1679134

PH_hs_0013577

TC10001714.hg

g13528824_3p_at

g13528824_3p_x_at

g8923008_3p_a_at

Participates

as a member of

EID3,NSMCE4A [nucleoplasm] (Homo sapiens)

Inferred To

nse-4 [nucleoplasm] (Caenorhabditis elegans)

nse4 [nucleoplasm] (Schizosaccharomyces pombe)

Nsmce4a [nucleoplasm] (Mus musculus)

Nsmce4a [nucleoplasm] (Rattus norvegicus)

NSE4 [nucleoplasm] (Saccharomyces cerevisiae)

nsmce4a [nucleoplasm] (Xenopus tropicalis)

NSMCE4A [nucleoplasm] (Bos taurus)

NSMCE4A [nucleoplasm] (Dictyostelium discoideum)

NSMCE4A [nucleoplasm] (Gallus gallus)

NSMCE4A [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENST00000369023, ENST00000369017, ENSP00000358013, ENSP00000358019

OpenTargets

ENSG00000107672

HPA

ENSG00000107672-NSMCE4A

PRO

Q9NXX6

Pharos - Targets

Q9NXX6

GlyGen

Q9NXX6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.527	2