Reactome | PIAS3 [nucleoplasm]

PIAS3 [nucleoplasm]

Stable Identifier

R-HSA-2993764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase PIAS3 ecNumber6.3.2.-/ecNumber, PIAS3_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        PIAS1,3 [nucleoplasm] (Homo sapiens)
        
        PIAS3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6X2 PIAS3

Gene Names

PIAS3

Chain

chain:1-628

Reference Genes

BioGPS Gene:10401 PIAS3

COSMIC (genes):PIAS3 PIAS3

CTD Gene:10401 PIAS3

dbSNP Gene:10401 PIAS3

ENSEMBL:ENSG00000131788 PIAS3

ENSEMBL_homo_sapiens_GENE:ENSG00000131788.16 PIAS3

HGNC:16861 PIAS3

KEGG Gene (Homo sapiens):10401 PIAS3

Monarch:10401 PIAS3

NCBI Gene:10401 PIAS3

OMIM:605987 PIAS3

UCSC:Q9Y6X2 PIAS3

Reference Transcript

RefSeq:NM_006099.3 PIAS3

Other Identifiers

10401

11716860_at

11745793_a_at

11745898_a_at

11757693_s_at

16669905

203035_PM_s_at

203035_s_at

2356305

2356308

2356310

2356311

2356312

2356313

2356315

2356317

2356319

2356320

2356321

2356324

2356325

2356326

2356328

2356329

2356331

2356332

2356333

32558_at

7904812

A_23_P149678

GE53594

GO:0000122

GO:0002376

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0008270

GO:0010629

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0023052

GO:0030154

GO:0033234

GO:0033235

GO:0036211

GO:0043226

GO:0045671

GO:0045892

GO:0046872

GO:0048856

GO:0060255

GO:0061665

GO:0071847

GO:0140096

GO:0140110

HMNXSV003002144

ILMN_1814966

PH_hs_0028427

g5174628_3p_a_at

Participates

as a member of

as a candidate of

PIAS1,3 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of PIAS3 [nucleoplasm] (Saccharomyces cerevisiae)

Su(var)2-10 [nucleoplasm] (Drosophila melanogaster)

PIAS3 [nucleoplasm] (Bos taurus)

PIAS3 [nucleoplasm] (Caenorhabditis elegans)

PIAS3 [nucleoplasm] (Gallus gallus)

PIAS3 [nucleoplasm] (Mus musculus)

PIAS3 [nucleoplasm] (Rattus norvegicus)

PIAS3 [nucleoplasm] (Saccharomyces cerevisiae)

PIAS3 [nucleoplasm] (Schizosaccharomyces pombe)

PIAS3 [nucleoplasm] (Sus scrofa)

pias3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_006090.2

OpenTargets

ENSG00000131788

GeneCards

Q9Y6X2

HPA

ENSG00000131788-PIAS3

Ensembl

ENST00000393045, ENSG00000131788, ENSP00000376765

PRO

Q9Y6X2

Pharos - Targets

Q9Y6X2

PDB

4MVT

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.581	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.553	2

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