Reactome | MUL1 [mitochondrial outer membrane]

MUL1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-2993772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Mitochondrial ubiquitin ligase activator of NFKB 1 ecNumber6.3.2.-/ecNumber, MUL1_HUMAN, MAPL

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q969V5 MUL1

Gene Names

MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218

Chain

chain:1-352

Reference Genes

BioGPS Gene:79594 MUL1

COSMIC (genes):MUL1 MUL1

CTD Gene:79594 MUL1

dbSNP Gene:79594 MUL1

ENSEMBL:ENSG00000090432 MUL1

HGNC:25762 MUL1

Monarch:79594 MUL1

NCBI Gene:79594 MUL1

OMIM:612037 MUL1

UCSC:Q969V5 MUL1

Reference Transcript

RefSeq:NM_024544.2 MUL1

Other Identifiers

11744145_at

11748221_a_at

16682835

218246_PM_at

218246_at

2400192

2400194

2400195

2400196

2400198

2400199

2400200

48016_at

63695_at

7913242

79594

GE82855

GO:0000209

GO:0000266

GO:0002039

GO:0003824

GO:0004842

GO:0005515

GO:0005739

GO:0005741

GO:0005777

GO:0006915

GO:0006919

GO:0006996

GO:0007005

GO:0010637

GO:0010821

GO:0012501

GO:0016020

GO:0016567

GO:0016740

GO:0016925

GO:0019789

GO:0030308

GO:0030424

GO:0031625

GO:0031647

GO:0031648

GO:0033235

GO:0042802

GO:0043025

GO:0043123

GO:0043226

GO:0045824

GO:0046872

GO:0050689

GO:0050821

GO:0051646

GO:0051881

GO:0051898

GO:0060339

GO:0061024

GO:0061630

GO:0071360

GO:0071650

GO:0090141

GO:0140096

GO:1901028

GO:1903861

GO:1904925

HMNXSV003038141

ILMN_1675055

PH_hs_0001043

TC01002315.hg

g13375704_3p_at

Participates

as a candidate of

MOM proteins [mitochondrial outer membrane] (Homo sapiens)

as a component of

MUL1 dimer [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

PolyUb-MUL1 [mitochondrial outer membrane]

Inferred To

MUL1 [mitochondrial outer membrane] (Bos taurus)

MUL1 [mitochondrial outer membrane] (Canis familiaris)

MUL1 [mitochondrial outer membrane] (Gallus gallus)

MUL1 [mitochondrial outer membrane] (Sus scrofa)

Mul1 [mitochondrial outer membrane] (Drosophila melanogaster)

Mul1 [mitochondrial outer membrane] (Mus musculus)

Mul1 [mitochondrial outer membrane] (Rattus norvegicus)

mul1 [mitochondrial outer membrane] (Danio rerio)

exc-14 [mitochondrial outer membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000264198, ENSP00000264198

OpenTargets

ENSG00000090432

IntEnz

2.3.2.27

HPA

ENSG00000090432-MUL1

PRO

Q969V5

Pharos - Targets

Q969V5

PDB

6K2K, 6M2D, 6M2C

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	4
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.527	2
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.462	2

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