Reactome | PIAS2-1 [nucleoplasm]

PIAS2-1 [nucleoplasm]

Stable Identifier

R-HSA-2993785

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PIAS2 isoform 1, E3 SUMO-protein ligase PIAS2 ecNumber6.3.2.-/ecNumber, PIAS2_HUMAN, PIAS2xbeta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75928-1 PIAS2

Gene Names

PIAS2, PIASX

Other Identifiers

11729722_a_at

11731291_a_at

11746816_a_at

11751292_a_at

1555513_PM_at

1555513_at

1555514_PM_a_at

1555514_a_at

1556492_PM_a_at

1556492_a_at

16855026

214442_PM_s_at

214442_s_at

214593_PM_at

214593_at

235107_PM_at

235107_at

238700_PM_at

238700_at

243624_PM_at

243624_at

37431_at

37432_g_at

37433_PM_at

37433_at

3806520

3806522

3806524

3806526

3806527

3806528

3806529

3806530

3806531

3806532

3806533

3806534

3806536

3806537

3806538

3806539

3806540

3806541

3806546

3806547

3806550

3806551

3806552

3806553

3806554

3806555

3806556

3806559

3806560

3806561

3806562

3806563

3806564

3806568

3806569

3806570

3806572

3806573

3806574

3806575

3806576

3806577

3806578

3806579

3806581

3806582

3806583

42255_at

45868_at

4850688_3p_s_at

55194_at

55199_g_at

55238_at

71192_r_at

74866_at

76801_i_at

76804_r_at

8023133

9063

A_23_P130316

A_24_P382266

A_32_P139311

A_33_P3349269

GE54708

GE574779

GO:0000785

GO:0003677

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006357

GO:0008270

GO:0016605

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0031625

GO:0043226

GO:0043433

GO:0046872

GO:0060090

GO:0060255

GO:0060766

GO:0061629

GO:0061665

GO:0140096

GO:0140110

HMNXSV003019826

Hs.101191.0.A1_3p_at

Hs.111323.0.S1_3p_at

Hs.111323.0.S1_3p_x_at

Hs.134462.0.A1_3p_at

Hs.293071.0.A1_3p_at

Hs.293071.0.A1_3p_x_at

Hs2.111323.3.S1_3p_at

Hs2.111323.3.S1_3p_s_at

Hs2.57769.1.S1_3p_s_at

ILMN_1658302

ILMN_1694799

ILMN_1713613

ILMN_1769406

ILMN_1854498

PH_hs_0003702

PH_hs_0025831

TC18000487.hg

TC18000917.hg

p7734

Participates

as a member of

Inferred To

PIAS2-1 [nucleoplasm] (Caenorhabditis elegans)

PIAS2-1 [nucleoplasm] (Rattus norvegicus)

PIAS2-1 [nucleoplasm] (Schizosaccharomyces pombe)

PIAS2-1 [nucleoplasm] (Sus scrofa)

PIAS2 [nucleoplasm] (Bos taurus)

PIAS2 [nucleoplasm] (Gallus gallus)

Pias2 isoform 2 [nucleoplasm] (Mus musculus)

Cross References

ENSEMBL

ENST00000324794, ENSG00000078043, ENSP00000465676, ENST00000585916, ENSP00000317163

OpenTargets

ENSG00000078043

GeneCards

PIAS2

HPA

ENSG00000078043-PIAS2

PRO

O75928

Pharos - Targets

O75928

GlyGen

O75928

PDB

4FO9, 2ASQ

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.853	8
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.782	8
UniProt:Q8IVL1 NAV2			0.666	4
UniProt:O95273 CCDB1			0.666	4
UniProt:Q96T51 RUFY1	3	p-Y389,400-RUFY1 [early endosome membrane] (R-HSA-5215951) RUFY1 [cytosol] (R-HSA-8871374) p-Y389,400-RUFY1 [cytosol] (R-HSA-8871352)	0.581	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q96HD9 ACY3	1	ACY3 [cytosol] (R-HSA-5433065)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:P20592 MX2	1	MX2 [cytosol] (R-HSA-1015675)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q969E8 TSR2			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.499	4
UniProt:P0C206 REX			0.488	2

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