Reactome | ANKLE2 binds VRK1,(VRK2)

ANKLE2 binds VRK1,(VRK2)

Stable Identifier

R-HSA-2995389

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 binds VRK1,(VRK2) (Homo sapiens)

General

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Both human ANKLE2 and the C. elegans ortholog LEM4 bind VRK1 (and possibly VRK2), the kinase responsible for phosphorylation of BANF1 (BAF) in mitotic prophase, and inhibit VRK1 catalytic activity (Asencio et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22770216	Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis Wallenfang, MR, Mall, M, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Asencio, C, Gorjánácz, M, Mattaj, IW	Cell	2012