Reactome | PIAS1,4 SUMOylates BRCA1 with SUMO2,3

PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Stable Identifier

R-HSA-2997616

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Conjugation of SUMO2,3 to BRCA1

ReviewStatus

5/5

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PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
20016603	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R	Nature	2009
20016594	The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress Morris, JR, Keppler, M, Solomon, E, Alamshah, A, Kiuchi, T, Galanty, Y, Pangon, L, Densham, R, Ng, T, Butler, L, Boutell, C, Weekes, D	Nature	2009
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
21147198	Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3 Stepien, G, Demidem, A, Rio, PG, Morvan, D, Vincent, A, Venezia, ND, Vialter, A	Biochim. Biophys. Acta	2011