Reactome | polySUMO2,3-BRCA1 [nucleoplasm]

polySUMO2,3-BRCA1 [nucleoplasm]

Stable Identifier

R-HSA-2997624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2 N-glycyl-lys BRCA1, Breast cancer type 1 susceptibility protein ecNumber6.3.2.-/ecNumber, BRCA1_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014

External Reference Information

External Reference

UniProt:P38398 BRCA1

Gene Names

BRCA1, RNF53

Chain

chain:1-1863

Reference Genes

COSMIC (genes):BRCA1 BRCA1

dbSNP Gene:672 BRCA1

ENSEMBL:ENSG00000012048 BRCA1

Participates

as an output of

PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K109-BRCA1 [nucleoplasm]

BRCA1 M1411T [nucleoplasm]

BRCA1 M1400V [nucleoplasm]

BRCA1 L1407P [nucleoplasm]

BRCA1 Y777* [nucleoplasm]

BRCA1 S1009* [nucleoplasm]

BRCA1 P724Lfs*12 [nucleoplasm]

BRCA1 S451* [nucleoplasm]

BRCA1 S864* [nucleoplasm]

BRCA1 P897Kfs*5 [nucleoplasm]

BRCA1 N555Kfs*17 [nucleoplasm]

BRCA1 Y1127Sfs*6 [nucleoplasm]

BRCA1 S886Cfs*16 [nucleoplasm]

BRCA1 V83Cfs*2 [nucleoplasm]

BRCA1 T464Pfs*11 [nucleoplasm]

BRCA1 G813Dfs*2 [nucleoplasm]

BRCA1 V340Gfs*6 [nucleoplasm]

BRCA1 Y655* [nucleoplasm]

BRCA1 W372* [nucleoplasm]

BRCA1 Y655Vfs*18 [nucleoplasm]

BRCA1 S242Rfs*5 [nucleoplasm]

BRCA1 E111Gfs*3 [nucleoplasm]

BRCA1 R71Kfs*10 [nucleoplasm]

BRCA1 A224Gfs*4 [nucleoplasm]

BRCA1 Q317* [nucleoplasm]

BRCA1 E1004* [nucleoplasm]

BRCA1 Q541* [nucleoplasm]

BRCA1 Q667* [nucleoplasm]

BRCA1 N909Kfs*6 [nucleoplasm]

BRCA1 T922Lfs*77 [nucleoplasm]

BRCA1 N567Pfs*16 [nucleoplasm]

BRCA1 N555Ifs*17 [nucleoplasm]

BRCA1 S988* [nucleoplasm]

BRCA1 S1007* [nucleoplasm]

BRCA1 E1288Kfs*19 [nucleoplasm]

BRCA1 V1176Ffs*34 [nucleoplasm]

BRCA1 S1217Rfs*21 [nucleoplasm]

BRCA1 E1282Afs*26 [nucleoplasm]

BRCA1 Q210Sfs*6 [nucleoplasm]

BRCA1 E453Rfs*22 [nucleoplasm]

BRCA1 E729Rfs*10 [nucleoplasm]

BRCA1 R1203* [nucleoplasm]

BRCA1 E686* [nucleoplasm]

BRCA1 R388* [nucleoplasm]

BRCA1 L290Yfs*8 [nucleoplasm]

BRCA1 E648* [nucleoplasm]

BRCA1 N1045* [nucleoplasm]

BRCA1 Q172Nfs*62 [nucleoplasm]

BRCA1 D1156Cfs*2 [nucleoplasm]

BRCA1 E597* [nucleoplasm]

BRCA1 Q210* [nucleoplasm]

BRCA1 E515* [nucleoplasm]

BRCA1 N287Qfs*6 [nucleoplasm]

BRCA1 Q169* [nucleoplasm]

BRCA1 N1121Kfs*12 [nucleoplasm]

BRCA1 E572* [nucleoplasm]

BRCA1 L1276* [nucleoplasm]

BRCA1 L431* [nucleoplasm]

BRCA1 E1214* [nucleoplasm]

BRCA1 L474* [nucleoplasm]

BRCA1 L502Afs*2 [nucleoplasm]

BRCA1 E1013Nfs*4 [nucleoplasm]

BRCA1 E1112Dfs*5 [nucleoplasm]

BRCA1 Q1144* [nucleoplasm]

BRCA1 Q94* [nucleoplasm]

BRCA1 N1265Kfs*4 [nucleoplasm]

BRCA1 C1146Lfs*8 [nucleoplasm]

BRCA1 Q934* [nucleoplasm]

BRCA1 D295Tfs*3 [nucleoplasm]

BRCA1 R1188Efs*3 [nucleoplasm]

BRCA1 C1225Sfs*10 [nucleoplasm]

BRCA1 R446Sfs*9 [nucleoplasm]

BRCA1 L668Pfs*33 [nucleoplasm]

BRCA1 A521Qfs*11 [nucleoplasm]

BRCA1 N1029Kfs*3 [nucleoplasm]

BRCA1 E1115* [nucleoplasm]

BRCA1 Q544* [nucleoplasm]

BRCA1 E577* [nucleoplasm]

BRCA1 P115* [nucleoplasm]

BRCA1 Q126* [nucleoplasm]

BRCA1 E457* [nucleoplasm]

BRCA1 A878Gfs*24 [nucleoplasm]

BRCA1 Q1281* [nucleoplasm]

BRCA1 Q202* [nucleoplasm]

BRCA1 N714Kfs*4 [nucleoplasm]

BRCA1 Q1240* [nucleoplasm]

BRCA1 K1183Rfs*4 [nucleoplasm]

BRCA1 K654Sfs*47 [nucleoplasm]

BRCA1 K1254Nfs*11 [nucleoplasm]

BRCA1 E1167* [nucleoplasm]

BRCA1 K1037* [nucleoplasm]

BRCA1 G911* [nucleoplasm]

BRCA1 G535* [nucleoplasm]

BRCA1 E111* [nucleoplasm]

BRCA1 E1107* [nucleoplasm]

BRCA1 E1033* [nucleoplasm]

BRCA1 E149* [nucleoplasm]

BRCA1 E1250* [nucleoplasm]

BRCA1 K467* [nucleoplasm]

BRCA1 E272* [nucleoplasm]

BRCA1 E1258* [nucleoplasm]

BRCA1 E1210* [nucleoplasm]

BRCA1 K1160* [nucleoplasm]

BRCA1 K519* [nucleoplasm]

BRCA1 E1112* [nucleoplasm]

BRCA1 E116* [nucleoplasm]

BRCA1 K935* [nucleoplasm]

BRCA1 K800* [nucleoplasm]

BRCA1 K894Tfs*8 [nucleoplasm]

BRCA1 K339Rfs*2 [nucleoplasm]

BRCA1 L1086Dfs*2 [nucleoplasm]

BRCA1 I986Sfs*14 [nucleoplasm]

BRCA1 K1079Nfs*2 [nucleoplasm]

BRCA1 K739Ifs*15 [nucleoplasm]

BRCA1 I925Nfs*13 [nucleoplasm]

BRCA1 K608Ifs*3 [nucleoplasm]

BRCA1 K893Rfs*107 [nucleoplasm]

BRCA1 H437* [nucleoplasm]

BRCA1 H816Qfs*3 [nucleoplasm]

BRCA1 F989Lfs*10 [nucleoplasm]

BRCA1 G928Afs*72 [nucleoplasm]

BRCA1 W372Yfs*5 [nucleoplasm]

BRCA1 E75Kfs*13 [nucleoplasm]

BRCA1 G948Efs*52 [nucleoplasm]

BRCA1 V757Ffs*8 [nucleoplasm]

BRCA1 H1284Tfs*23 [nucleoplasm]

BRCA1 E733* [nucleoplasm]

BRCA1 F869Vfs*35 [nucleoplasm]

BRCA1 E720* [nucleoplasm]

BRCA1 S426* [nucleoplasm]

BRCA1 E673* [nucleoplasm]

BRCA1 E787* [nucleoplasm]

BRCA1 E881* [nucleoplasm]

BRCA1 E848* [nucleoplasm]

BRCA1 E842* [nucleoplasm]

BRCA1 F989Lfs*11 [nucleoplasm]

BRCA1 G817Vfs*29 [nucleoplasm]

BRCA1 E836* [nucleoplasm]

BRCA1 G911Efs*89 [nucleoplasm]

BRCA1 E904* [nucleoplasm]

BRCA1 C64R [nucleoplasm]

BRCA1 C61G [nucleoplasm]

K6PolyUb,p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

BRCA1 [nucleoplasm]

K6PolyUb-BRCA1 [nucleoplasm]

p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

BRCA1 E23Vfs*17 [nucleoplasm]

BRCA1 E23Rfs*18 [nucleoplasm]

BRCA1 C24F [nucleoplasm]

BRCA1 C61Y [nucleoplasm]

BRCA1 E23Afs*18 [nucleoplasm]

BRCA1 Q12Tfs*5 [nucleoplasm]

BRCA1 H41Q [nucleoplasm]

BRCA1 C27A [nucleoplasm]

BRCA1 T37R [nucleoplasm]

BRCA1 C44F [nucleoplasm]

BRCA1 C64G [nucleoplasm]

BRCA1 C47G [nucleoplasm]

BRCA1 M18T [nucleoplasm]

BRCA1 H41A [nucleoplasm]

BRCA1 C24R [nucleoplasm]

BRCA1 H41R [nucleoplasm]

BRCA1 C39Y [nucleoplasm]

Inferred To

Brca1 [nucleoplasm] (Mus musculus)

Brca1 [nucleoplasm] (Rattus norvegicus)

BRCA1 [nucleoplasm] (Bos taurus)

BRCA1 [nucleoplasm] (Sus scrofa)

brca1 [nucleoplasm] (Xenopus tropicalis)

polySUMO2,3-BRCA1 [nucleoplasm] (Dictyostelium discoideum)

polySUMO2,3-BRCA1 [nucleoplasm] (Gallus gallus)

polySUMO2,3-BRCA1 [nucleoplasm] (Plasmodium falciparum)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BX63 BRIP1	2	p-S990,Ac-K1249-BRIP1 [nucleoplasm] (R-HSA-5687710) BRIP1 [cytosol] (R-HSA-2564781)	0.979	33
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.958	20
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.935	15
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.909	27
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.86	16
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.811	16
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.78	13
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.747	5
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.727	8
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.718	6
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.715	6
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.714	4
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.7	5
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.65	4
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) polySUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.65	3
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.629	4
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.615	3
UniProt:P46736 BRCC3	2	BRCC3 [cytosol] (R-HSA-5691415) BRCC3 [nucleoplasm] (R-HSA-5682577)	0.615	3
UniProt:P78347 GTF2I			0.61	5
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.602	5
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.602	3
UniProt:Q6PJG6 BRAT1			0.602	6
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.591	5
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.589	2
UniProt:Q86YA3 ZGRF1			0.584	4
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.583	3
UniProt:Q9GZX5 ZNF350	1	ZNF350 [nucleoplasm] (R-HSA-1247526)	0.581	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543) PPP1CB [nucleoplasm] (R-HSA-62003)	0.581	3
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.556	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.544	2
UniProt:P03126 VE6			0.544	7
UniProt:P03129 VE7			0.544	5
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.543	3
UniProt:Q13085 ACACA	2	ACACA [cytosol] (R-HSA-1660609) Btn-ACACA [cytosol] (R-HSA-2976730)	0.524	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.524	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.524	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.508	2
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.508	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.508	3
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.499	4
UniProt:Q96SB3 NEB2			0.499	4
UniProt:Q9ULW0 TPX2	2	TPX2 [nucleoplasm] (R-HSA-2564700) TPX2 [cytosol] (R-HSA-8853407)	0.483	4
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.483	2
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.483	2
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.463	3
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285)	0.463	3

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