Reactome | CD320-mediated TCN2:RCbl uptake and delivery to lysosome

CD320-mediated TCN2:RCbl uptake and delivery to lysosome

Stable Identifier

R-HSA-3000112

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, lysosomal lumen, extracellular region

ReviewStatus

5/5

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CD320-mediated TCN2:RCbl uptake and delivery to lysosome

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Once the complex of transcobalamin 2 and cobalamins (RCbl) bound to CD320 receptor (TCN2:RCbl:CD320) is internalised by endocytosis, CD320 dissociates, possibly facilitated by the low affinity of CD320 for TCN2 at acidic pH (Alam et al. 2016), to return to the plasma membrane (Youngdahl Turner et al. 1979), while TCN2:RCbl is delivered to lysosomes and degraded, releasing RCbl.

Literature References

PubMed ID	Title	Journal	Year
759210	Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts Mellman, IS, Youngdahl-Turner, P, Rosenberg, LE, Allen, RH	Exp. Cell Res.	1979
27411955	Structural basis of transcobalamin recognition by human CD320 receptor Zenobi, R, Alam, A, Prinz, B, Locher, KP, Bloch, JS, Woo, JS, Chen, F, Schmitz, J, Root, K	Nat Commun	2016