CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome

Stable Identifier
R-HSA-3000137
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, lysosomal lumen
ReviewStatus
5/5
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CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
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The cubilin protein:amnionless (CUBN:AMN) complex mediates the endocytosis of gastric internal factor complexes with cobalamins (CBLIF:RCbl) into coated vesicles of mucosal cells of the distal ileum. There, the CBLIF:RCbl complex dissociates from CUBN:AMN, which returns to the plasma membrane while CBLIF:RCbl is delivered to lysosomes (Fyfe et al. 2004).

Literature References
PubMed ID Title Journal Year
14576052 The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

Tanner, SM, Højrup, P, Fyfe, JC, He, Q, Moestrup, SK, de la Chapelle, A, Madsen, M, Christensen, EI

Blood 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cargo receptor activity of CUBN:AMN:CBLIF:RCbl [plasma membrane]

Physical Entity
CUBN:AMN:CBLIF:RCbl [plasma membrane] (Homo sapiens)
Activity
cargo receptor activity (GO:0038024)
Orthologous Events
CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)
CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)
CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)
Authored
Jassal, B  (2013-01-24)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-24)
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