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FGD4 [cytosol]
Stable Identifier
R-HSA-3000215
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FYVE, RhoGEF and PH domain-containing protein 4, FGD4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
FGD4 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
FGD4 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
FGD4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96M96 FGD4
Gene Names
FGD4, FRABP, ZFYVE6
Chain
chain:1-766
Reference Genes
BioGPS Gene:121512 FGD4
COSMIC (genes):FGD4 FGD4
CTD Gene:121512 FGD4
dbSNP Gene:121512 FGD4
ENSEMBL:ENSG00000139132 FGD4
HGNC:19125 FGD4
KEGG:hsa:121512 FGD4
Monarch:121512 FGD4
NCBI Gene:121512 FGD4
OMIM:611104 FGD4
UCSC:Q96M96 FGD4
Reference Transcript
RefSeq:NM_001304480.1 FGD4
RefSeq:XM_011520555.1 FGD4
RefSeq:NM_139241.3 FGD4
RefSeq:XM_011520556.1 FGD4
RefSeq:NM_001330373.1 FGD4
RefSeq:NM_001330374.1 FGD4
Other Identifiers
11726393_at
11726394_a_at
11726395_s_at
11747232_a_at
11749119_a_at
121512
16749782
16749824
227948_PM_at
227948_at
230559_PM_x_at
230559_x_at
242445_PM_at
242445_at
3410585
3410586
3410615
3410616
3410632
3410636
3410637
3410638
3410639
3410641
3410644
3410645
3410646
3410656
3410657
3410658
3410659
3410660
3410663
3410664
3410665
3410667
3410668
3410671
3410672
3410673
3410674
3410675
3410676
3410679
3410680
3410681
3410682
3410683
3410684
3410685
3410686
3410687
3410688
3410689
3410690
47117_at
47118_g_at
47938_at
62966_at
76349_r_at
7954729
91427_at
A_14_P103709
A_14_P105702
A_14_P108573
A_24_P158946
A_24_P937325
A_33_P3404588
GE470249
GO:0001726
GO:0003779
GO:0005085
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0007010
GO:0008092
GO:0008360
GO:0030027
GO:0030032
GO:0030035
GO:0030036
GO:0030175
GO:0031267
GO:0042995
GO:0043087
GO:0043226
GO:0046847
GO:0046872
GO:0051056
GO:0098772
HMNXSV003002750
HMNXSV003044943
Hs.124442.0.A1_3p_at
Hs.154263.0.A1_3p_at
Hs.293097.0.A1_3p_at
ILMN_1698728
PH_hs_0019495
TC12000297.hg
TC12002308.hg
Participates
as a member of
CDC42 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
fgd4 [cytosol]
(Xenopus tropicalis)
exc-5 [cytosol]
(Caenorhabditis elegans)
FGD4 [cytosol]
(Bos taurus)
FGD4 [cytosol]
(Canis familiaris)
FGD4 [cytosol]
(Gallus gallus)
FGD4 [cytosol]
(Mus musculus)
FGD4 [cytosol]
(Rattus norvegicus)
FGD4 [cytosol]
(Sus scrofa)
fgd4a [cytosol]
(Danio rerio)
Cross References
RefSeq
XP_011518857.1
,
NP_001317303.1
,
XP_011518858.1
,
NP_001317302.1
,
NP_001291409.1
,
NP_640334.2
ENSEMBL
ENST00000583694
,
ENSP00000394487
,
ENSP00000433666
,
ENST00000427716
,
ENST00000525053
,
ENSP00000462623
OpenTargets
ENSG00000139132
HPA
ENSG00000139132-FGD4
PRO
Q96M96
Pharos - Targets
Q96M96
Orphanet
FGD4
HMDB Protein
HMDBP08393
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
PRKCA [plasma membrane]
(R-HSA-156469)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.527
2
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