Reactome | BORA binds PLK1 and AURKA

BORA binds PLK1 and AURKA

Stable Identifier

R-HSA-3000319

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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BORA is able to interact with both AURKA (Aurora A kinase) and PLK1. Binding of BORA to PLK1 increases the accessibility of PLK1 threonine residue T210 and also brings PLK1 in proximity to AURKA, enabling AURKA to phosphorylate T210 of PLK1 and thereby activate PLK1 (Seki et al. 2008). While BORA is required for mitotic activation of AURKA in Drosophila (Hutterer et al. 2006), it does not significantly activate AURKA in human cells (Seki et al. 2008). AURKA is able to phosphorylate BORA in vitro, but the functional significance of this modification has not been determined (Hutterer et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
18566290	Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry Seki, A, Coppinger, JA, Jang, CY, Yates, JR, Fang, G	Science	2008
16890155	Mitotic activation of the kinase Aurora-A requires its binding partner Bora Hutterer, A, Berdnik, D, Wirtz-Peitz, F, Zigman, M, Schleiffer, A, Knoblich, JA	Dev. Cell	2006