Phosphorylated BORA binds SCF-beta-TrCp1/2

Stable Identifier
R-HSA-3000339
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated BORA binds SCF-beta-TrCp1/2
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The substrate recognition subunits beta-TrCP (BTRC) and beta-TrCP2 (FBXW11) of SCF-beta-TrPC1 and SCF-beta-TrPC2 ubiquitin ligases, respectively, bind the phosphorylated DSGYNT motif of BORA (Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Yates, JR, Jang, CY, Fang, G, Du, H

J. Cell Biol. 2008
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Orthologous Events
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)
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Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Danio rerio)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Rattus norvegicus)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-01-25)
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