Reactome | monoSUMO1-K297-SP100 [nucleoplasm]

monoSUMO1-K297-SP100 [nucleoplasm]

Stable Identifier

R-HSA-3000382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys297 SP100, Nuclear autoantigen Sp-100, SP100_HUMAN

Locations in the PathwayBrowser for interactor UniProt:V9HWG0 V9HWG0

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Literature References

PubMed ID	Title	Journal	Year
10212234	The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers Reich, B, Sternsdorf, T, Will, H, Jensen, K	J. Biol. Chem.	1999

External Reference Information

External Reference

UniProt:P23497 SP100

Gene Names

SP100

Chain

initiator methionine:, chain:2-879

Reference Genes

BioGPS Gene:6672 SP100

COSMIC (genes):SP100 SP100

CTD Gene:6672 SP100

dbSNP Gene:6672 SP100

ENSEMBL:ENSG00000067066 SP100

HGNC:11206 SP100

KEGG:hsa:6672 SP100

Monarch:6672 SP100

NCBI Gene:6672 SP100

OMIM:604585 SP100

UCSC:P23497 SP100

Reference Transcript

Participates

as an output of

RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)

Other forms of this molecule

SP100 [nucleoplasm]

polySUMO2-K297-SP100 [nucleoplasm]

Inferred To

Sp100 [nucleoplasm] (Mus musculus)

Sp100 [nucleoplasm] (Rattus norvegicus)

aire [nucleoplasm] (Xenopus tropicalis)

LOC100517129 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 297

Coordinate

297

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_003104.2, NP_001073860.1, NP_001193633.1, NP_001193630.1, NP_001193632.1, NP_001193631.1

Guide to Pharmacology - Targets

2777

OpenTargets

ENSG00000067066

ENSEMBL

ENSP00000386427, ENSP00000386404, ENSP00000386998, ENST00000340126, ENSG00000067066, ENSP00000343023, ENST00000409897, ENSP00000264052, ENST00000409112, ENST00000409341, ENST00000264052, ENST00000427101, ENSP00000399389

GeneCards

SP100

HPA

ENSG00000067066-SP100

PRO

P23497

Pharos - Targets

P23497

GlyGen

P23497

PDB

5PYG, 5PWZ, 5PYQ, 5PZ7, 5PWP, 5PWF, 5PXZ, 5PXB, 5PXR, 5PYH, 5PXJ, 5PYZ, 5PYS, 5PXT, 5PWJ, 5PWR, 5PYL, 5PYE, 5PYU, 6G5P, 5PX5, 5PXV, 5PXF, 5PX0, 5PX7, 5PXX, 5PXP, 5PZJ, 5PZD, 5FB0, 5PYY, 5PZ2, 5PYF, 5PWI, 5PX1, 5PYO, 5PYW, 5PXY, 5PWY, 5PXA, 5PY3, 5PZ4, 5PXI, 5PYA, 5PX3, 5PY5, 5PZ6, 5PYD, 5PYK, 5PY7, 5PWU, 5PXE, 5PWN, 1H5P, 5PY1, 5PY9, 5PZI, 5PWW, 5FB1, 5PWM, 5PZC, 5PWS, 5PXL, 5PYX, 5PYP, 5PWH, 5PWQ, 5PWX, 5PZ8, 5PZ0, 5PXH, 5PXQ, 5PYC, 5PYR, 5PXD, 4PTB, 5PXS, 5PYT, 5PYJ, 5PXN, 5PZH, 5PXU, 5PX6, 5PZB, 5PWE, 5PZF, 5PXW, 5PXO, 5PX8, 5PWL, 5PY4, 5PXK, 5PZ1, 5PZ9, 5PX2, 5PX9, 5PWG, 5PYV, 5PYN, 5PXG, 5PY2, 5PYI, 5PYB, 5PZ3, 5PXC, 5PX4, 5PWK, 5PYM, 5PZ5, 6G5N, 5PY6, 5PXM, 5PZG, 5PWT, 5PZA, 5PY0, 5PWO, 5PY8, 5PZE, 5PWV

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.764	6
UniProt:Q8TF65 GIPC2			0.666	4
UniProt:Q9Y228 T3JAM			0.666	4
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.666	6
UniProt:P03169 VIE1			0.625	4
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.602	5
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.556	3
UniProt:Q14498-3 RBM39			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q92630 DYRK2	3	DYRK2 [nucleoplasm] (R-HSA-3215037) p-T106,S442-DYRK2 [nucleoplasm] (R-HSA-6798368) PolyUb-DYRK2 [nucleoplasm] (R-HSA-6798383)	0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:V9HWG0 V9HWG0			0.556	3
UniProt:P0DTD1-PRO_0000449627 REP			0.556	3
UniProt:Q96GY0 ZC21A			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:P23497 SP100	3	SP100 [nucleoplasm] (R-HSA-1031705) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454)	0.553	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.547	2
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [secretory granule lumen] (R-HSA-6803337)	0.527	2
UniProt:P55854 SUMO3	5	lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) SUMO3 [nucleoplasm] (R-HSA-2984269) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830)	0.524	2
UniProt:P14921 ETS1	2	p-T38-ETS1 [nucleoplasm] (R-HSA-3132720) ETS1 [nucleoplasm] (R-HSA-1629809)	0.508	4
UniProt:P03410 TAX			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:Q03060 CREM			0.488	2
UniProt:Q85601 REX			0.488	2
UniProt:Q8AZK7 EBNA5			0.482	2

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