RANBP2 of the nuclear pore complex SUMOylates PML with SUMO2 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998, Tatham et al. 2005). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for UBE2I participates in SUMOylation of PML with SUMO2. SUMO2 colocalizes significantly with PML bodies (Vertegaal et al. 2004).
Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I
Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K
Kim, S, Tatham, MH, Chen, Y, Hay, RT, Jaffray, E, Song, J
Andersen, JS, Hay, RT, Ogg, SC, Lamond, AI, Jaffray, E, Rodriguez, MS, Vertegaal, AC, Mann, M
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
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