UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

Stable Identifier
Reaction [transition]
Homo sapiens
Conjugation of SUMO1 to RANGAP1
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The majority of RANGAP1 in the cell is conjugated with SUMO1 by the E3 ligase UBE2l (Ubc9) (Knipscheer et al. 1998, Lee et al. 1998). SUMO1 targets RANGAP1 to the nucleoporin RANBP2 (Mahajan et al. 1997).

Literature References
PubMed ID Title Journal Year
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P

Mol. Cell 2008
9019411 A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

Guan, T, Gerace, L, Melchior, F, Mahajan, R, Delphin, C

Cell 1997
9497385 Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue

Tian, Q, Anderson, P, Matunis, MJ, Melchior, F, Mahajan, R, Lee, GW

J. Biol. Chem. 1998
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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