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Cytosolic PLK1 translocates to the nucleus
Stable Identifier
R-HSA-3002798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Cytosolic PLK1 translocates to the nucleus (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PLK1 is induced in S phase and can be find in both cytosol and nucleus in S and G2 phases of the cell cycle. PLK1 possesses a bipartite nuclear localization signal (NLS) that enables it to enter the nucleus (Taniguchi et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
12364337
Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal
Nishida, E
,
Taniguchi, E
,
Toyoshima-Morimoto, F
J. Biol. Chem.
2002
Participants
Input
p-T210-PLK1 [cytosol]
(Homo sapiens)
Output
p-T210-PLK1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Orthologous Events
Cytosolic PLK1 translocates to the nucleus (Bos taurus)
Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)
Cytosolic PLK1 translocates to the nucleus (Canis familiaris)
Cytosolic PLK1 translocates to the nucleus (Danio rerio)
Cytosolic PLK1 translocates to the nucleus (Dictyostelium discoideum)
Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)
Cytosolic PLK1 translocates to the nucleus (Gallus gallus)
Cytosolic PLK1 translocates to the nucleus (Mus musculus)
Cytosolic PLK1 translocates to the nucleus (Plasmodium falciparum)
Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)
Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)
Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)
Cytosolic PLK1 translocates to the nucleus (Sus scrofa)
Cytosolic PLK1 translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2013-01-29)
Reviewed
Weil, R (2013-02-07)
Created
Orlic-Milacic, M (2013-01-28)
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