Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GRIA2 [endocytic vesicle membrane]
Stable Identifier
R-HSA-3004487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle membrane
Synonyms
Glutamate receptor 2, GRIA2_HUMAN, GluR2
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)
Ca impermeable AMPA receptors [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
Ca impermeable AMPA receptors [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [endocytic vesicle membrane] (Homo sapiens)
GRIA2 [endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42262 GRIA2
Gene Names
GRIA2, GLUR2
Chain
signal peptide:1-24, chain:25-883
Reference Genes
BioGPS Gene:2891 GRIA2
COSMIC (genes):GRIA2 GRIA2
CTD Gene:2891 GRIA2
dbSNP Gene:2891 GRIA2
ENSEMBL:ENSG00000120251 GRIA2
ENSEMBL_homo_sapiens_GENE:ENSG00000120251.22 GRIA2
HGNC:4572 GRIA2
KEGG Gene (Homo sapiens):2891 GRIA2
Monarch:2891 GRIA2
NCBI Gene:2891 GRIA2
OMIM:138247 GRIA2
UCSC:P42262 GRIA2
Reference Transcript
RefSeq:XM_017008117.1 GRIA2
RefSeq:NM_001083619.1 GRIA2
RefSeq:XM_017008116.1 GRIA2
RefSeq:NM_000826.3 GRIA2
RefSeq:NM_001083620.1 GRIA2
Other Identifiers
11721263_at
11721264_a_at
16971822
205358_PM_at
205358_at
236538_PM_at
236538_at
2749223
2749224
2749225
2749226
2749227
2749228
2749229
2749230
2749243
2749244
2749245
2749246
2749247
2749250
2749254
2749255
2749256
2749258
2749261
2749270
2749271
2749276
2749277
2749279
2749280
2749282
2749286
2749287
2749289
2749290
2749291
2749292
2749293
2749294
2749295
2891
40746_at
73227_r_at
73450_at
8098021
A_14_P134253
A_23_P340617
A_24_P914688
A_32_P172339
A_33_P3230161
GE57666
GO:0001540
GO:0004970
GO:0004971
GO:0005215
GO:0005216
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0006811
GO:0007165
GO:0007215
GO:0007268
GO:0009897
GO:0014069
GO:0015276
GO:0016020
GO:0023052
GO:0030425
GO:0030666
GO:0031410
GO:0032279
GO:0032281
GO:0034220
GO:0035235
GO:0035249
GO:0038023
GO:0043025
GO:0043197
GO:0043226
GO:0045202
GO:0045211
GO:0050804
GO:0055085
GO:0060076
GO:0060078
GO:0060089
GO:0098794
GO:0098839
GO:0098843
GO:1904315
HMNXSV003056960
Hs.225106.0.A1_3p_at
ILMN_1660372
L20814_at
PH_hs_0023863
TC04000799.hg
g4758479_3p_at
Participates
as a component of
AMPA receptors containing GluR2 (heteromers) [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [endocytic vesicle membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
p-S880-GRIA2 [plasma membrane]
GRIA2 [plasma membrane]
Inferred To
Ir76b [endocytic vesicle membrane]
(Drosophila melanogaster)
glr-1 [endocytic vesicle membrane]
(Caenorhabditis elegans)
GRIA2 [endocytic vesicle membrane]
(Bos taurus)
GRIA2 [endocytic vesicle membrane]
(Caenorhabditis elegans)
GRIA2 [endocytic vesicle membrane]
(Canis familiaris)
GRIA2 [endocytic vesicle membrane]
(Gallus gallus)
GRIA2 [endocytic vesicle membrane]
(Mus musculus)
GRIA2 [endocytic vesicle membrane]
(Rattus norvegicus)
GRIA2 [endocytic vesicle membrane]
(Sus scrofa)
Ir93a [endocytic vesicle membrane]
(Drosophila melanogaster)
glr-5 [endocytic vesicle membrane]
(Caenorhabditis elegans)
glr-6 [endocytic vesicle membrane]
(Caenorhabditis elegans)
Ir8a [endocytic vesicle membrane]
(Drosophila melanogaster)
glr-2 [endocytic vesicle membrane]
(Caenorhabditis elegans)
Ekar [endocytic vesicle membrane]
(Drosophila melanogaster)
glr-4 [endocytic vesicle membrane]
(Caenorhabditis elegans)
GluRIA [endocytic vesicle membrane]
(Drosophila melanogaster)
Ir21a [endocytic vesicle membrane]
(Drosophila melanogaster)
DmelCG11155 [endocytic vesicle membrane]
(Drosophila melanogaster)
Homologues of GRIA2 [endocytic vesicle membrane]
(Caenorhabditis elegans)
Homologues of GRIA2 [endocytic vesicle membrane]
(Drosophila melanogaster)
glr-7 [endocytic vesicle membrane]
(Caenorhabditis elegans)
GluRIB [endocytic vesicle membrane]
(Drosophila melanogaster)
Ir25a [endocytic vesicle membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016863605.1
,
NP_001077088.1
,
XP_016863606.1
,
NP_001077089.1
,
NP_000817.2
Guide to Pharmacology - Targets
445
OpenTargets
ENSG00000120251
HPA
ENSG00000120251-GRIA2
GeneCards
P42262
ZINC target
P42262
Ensembl
ENST00000393815
,
ENSP00000296526
,
ENSP00000377403
,
ENST00000507898
,
ENSP00000264426
,
ENST00000645636
,
ENSP00000515472
,
ENST00000703765
,
ENSP00000426845
,
ENSP00000495569
,
ENST00000264426
,
ENSG00000120251
,
ENST00000296526
PRO
P42262
Pharos - Targets
P42262
Orphanet
26516
HMDB Protein
HMDBP07718
PDB
5YBF
,
5ZG2
,
5ZG1
,
5H8S
,
2WJX
,
2WJW
,
3R7X
,
3UA8
,
5ZG0
,
2XHD
,
3RN8
,
3RNN
,
5YBG
,
5ZG3
,
7F3O
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9EP80 Pick1
3
PICK1 [endocytic vesicle membrane]
(R-RNO-417017)
Pick1 [plasma membrane]
(R-RNO-8858476)
PICK1 [plasma membrane]
(R-RNO-416989)
0.558
2
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.544
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text