Reactome | HDAC7 [nucleoplasm]

HDAC7 [nucleoplasm]

Stable Identifier

R-HSA-3004534

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 7, HDAC7_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)
        
        UBE2I,HDAC7 [nucleoplasm] (Homo sapiens)
        
        HDAC7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUI4 HDAC7

Gene Names

HDAC7, HDAC7A

Chain

chain:1-952

Reference Genes

BioGPS Gene:51564 HDAC7

COSMIC (genes):HDAC7 HDAC7

CTD Gene:51564 HDAC7

dbSNP Gene:51564 HDAC7

ENSEMBL:ENSG00000061273 HDAC7

ENSEMBL_homo_sapiens_GENE:ENSG00000061273.18 HDAC7

HGNC:14067 HDAC7

KEGG Gene (Homo sapiens):51564 HDAC7

Monarch:51564 HDAC7

NCBI Gene:51564 HDAC7

OMIM:606542 HDAC7

UCSC:Q8WUI4 HDAC7

Reference Transcript

Other Identifiers

11720696_a_at

11720697_a_at

11734575_a_at

11748063_x_at

11752046_x_at

11756981_s_at

16763713

217937_3p_s_at

217937_PM_s_at

217937_s_at

3452744

3452745

3452746

3452749

3452750

3452752

3452753

3452754

3452757

3452758

3452759

3452765

3452766

3452767

3452771

3452772

3452773

3452774

3452775

3452776

3452777

3452779

3452780

3452781

3452783

3452784

3452785

3452787

3452789

3452791

3452792

3452794

3452804

46721_at

51564

7962659

A_24_P647146

GE56473

GO:0000118

GO:0000122

GO:0001570

GO:0003682

GO:0003714

GO:0003824

GO:0004407

GO:0005080

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006476

GO:0007043

GO:0010558

GO:0016071

GO:0016575

GO:0016740

GO:0016787

GO:0016925

GO:0019789

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0032703

GO:0033558

GO:0034330

GO:0036211

GO:0043226

GO:0043229

GO:0045668

GO:0045892

GO:0046872

GO:0048856

GO:0048870

GO:0050684

GO:0071889

GO:0090050

GO:0140096

GO:0140110

GO:0140297

GO:1901223

HMNXSV003023665

ILMN_1728521

ILMN_1794485

TC12001438.hg

Participates

as a member of

Inferred To

hda-4 [nucleoplasm] (Caenorhabditis elegans)

hdaD [nucleoplasm] (Dictyostelium discoideum)

Homologues of HDAC7 [nucleoplasm] (Dictyostelium discoideum)

HDAC7 [nucleoplasm] (Bos taurus)

HDAC7 [nucleoplasm] (Canis familiaris)

HDAC7 [nucleoplasm] (Dictyostelium discoideum)

HDAC7 [nucleoplasm] (Drosophila melanogaster)

HDAC7 [nucleoplasm] (Gallus gallus)

HDAC7 [nucleoplasm] (Mus musculus)

HDAC7 [nucleoplasm] (Sus scrofa)

HDAC7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011536783.1, NP_001091886.1, NP_001295019.1, XP_011536784.1, NP_056216.2

ZINC - World Drugs

HDAC7_HUMAN

Guide to Pharmacology - Targets

2661

OpenTargets

ENSG00000061273

ZINC - FDA approved

HDAC7_HUMAN

ZINC - Substances

HDAC7_HUMAN

ZINC target

Q8WUI4

ZINC - Biogenic

HDAC7_HUMAN

PRO

Q8WUI4

PDB

3ZNS, 3C0Z, 3ZNR, 3C10, 3C0Y

ZINC - Investigational

HDAC7_HUMAN

HPA

ENSG00000061273-HDAC7

GeneCards

Q8WUI4

Ensembl

ENST00000552960, ENST00000354334, ENST00000080059, ENSP00000351326, ENSG00000061273, ENSP00000080059, ENST00000427332, ENSP00000448532, ENSP00000404394

Pharos - Targets

Q8WUI4

ZINC - Predictions - Purchasable

HDAC7_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.802	5
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.688	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q8CFN5 Mef2c	3	phospho-Mef2c [nucleoplasm] (R-MMU-448838) Mef2c [nucleoplasm] (R-MMU-1605569) Mef2c [nucleoplasm] (R-MMU-199938)	0.499	2