Reactome | SNAP25(1-197) [plasma membrane]

SNAP25(1-197) [plasma membrane]

Stable Identifier

R-HSA-3004546

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Synaptosomal-associated protein 25, residues 1-197

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Literature References

PubMed ID	Title	Journal	Year
9886085	Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage Niemann, H, Nauenburg, S, Dorries, C, Binz, T, Jahnz, M, Bade, S, Yoshino, K, Vaidyanathan, VV	J Neurochem	1999
8294407	Proteolysis of SNAP-25 by types E and A botulinal neurotoxins Südhof, TC, Link, E, Yamasaki, S, Baumeister, A, Niemann, H, Binz, T, Jahn, R, Blasi, J	J Biol Chem	1994

External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

BioGPS Gene:6616 SNAP25

COSMIC (genes):SNAP25 SNAP25

CTD Gene:6616 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

ENSEMBL_homo_sapiens_GENE:ENSG00000132639.15 SNAP25

HGNC:11132 SNAP25

KEGG Gene (Homo sapiens):6616 SNAP25

Monarch:6616 SNAP25

NCBI Gene:6616 SNAP25

OMIM:600322 SNAP25

UCSC:P60880 SNAP25

Reference Transcript

Other Identifiers

11733726_a_at

11733727_s_at

11750076_a_at

11750077_x_at

16911418

202507_PM_s_at

202507_s_at

202508_PM_s_at

202508_s_at

38484_at

3876244

3876246

3876247

3876248

3876249

3876252

3876253

3876254

3876258

3876259

3876262

3876265

3876271

3876272

3876279

3876280

3876282

3876283

3876288

3876289

3876310

6616

8060963

A_23_P210756

A_33_P3338693

D21267_at

GE61378

GO:0000149

GO:0001504

GO:0001917

GO:0005215

GO:0005249

GO:0005484

GO:0005515

GO:0005737

GO:0005768

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0006887

GO:0007268

GO:0007269

GO:0007409

GO:0007616

GO:0007626

GO:0008021

GO:0008076

GO:0008092

GO:0008289

GO:0008306

GO:0010975

GO:0015629

GO:0016020

GO:0016079

GO:0016081

GO:0016082

GO:0016192

GO:0016197

GO:0017022

GO:0017075

GO:0019904

GO:0023052

GO:0030027

GO:0030154

GO:0030175

GO:0030182

GO:0030424

GO:0030426

GO:0031083

GO:0031201

GO:0031410

GO:0031629

GO:0031982

GO:0032024

GO:0034330

GO:0035493

GO:0035579

GO:0036477

GO:0042734

GO:0043005

GO:0043025

GO:0043226

GO:0044295

GO:0044325

GO:0045202

GO:0046887

GO:0048306

GO:0048471

GO:0048787

GO:0048791

GO:0048856

GO:0050796

GO:0050877

GO:0051963

GO:0055085

GO:0060090

GO:0060291

GO:0061024

GO:0065003

GO:0070032

GO:0070033

GO:0070044

GO:0070201

GO:0070821

GO:0071805

GO:0097470

GO:0098794

GO:0098888

GO:0098967

GO:0098978

GO:0099525

GO:0099590

HMNXSV003025439

HMNXSV003041197

ILMN_1740555

ILMN_2408080

PH_hs_0023120

TC20000082.hg

g307425_3p_a_at

g4507098_3p_a_at

Participates

as an output of

botA LC cleaves target cell SNAP25 (Homo sapiens)

Other forms of this molecule

SNAP25(198-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25(199-206) [cytosol]

SNAP25 [specific granule membrane]

SNAP25 [tertiary granule membrane]

SNAP25 [plasma membrane]

Modified Residues

Name

S-palmitoyl-L-cysteine at 85

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 88

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 90

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 92

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Disease

Name	Identifier	Synonyms
botulism	DOID:11976	Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning

Cross References

RefSeq

XP_016883510.1, NP_001309836.1, NP_001309831.1, NP_001309839.1, NP_001309838.1, NP_001309833.1, NP_570824.1, XP_005260865.1, NP_001309835.1, NP_001309834.1, NP_003072.2, XP_016883511.1, NP_001309832.1, NP_001309837.1

OpenTargets

ENSG00000132639

GeneCards

P60880

HPA

ENSG00000132639-SNAP25

Ensembl

ENSP00000509759, ENST00000689858, ENST00000689757, ENSP00000254976, ENSP00000509312, ENST00000691353, ENSP00000510109, ENSP00000508837, ENSP00000508939, ENST00000304886, ENST00000706269, ENSG00000132639, ENST00000691161, ENST00000691665, ENSP00000307341, ENSP00000516314, ENST00000687785, ENSP00000509287, ENSP00000510558, ENST00000254976, ENSP00000510219, ENST00000685131, ENSP00000510663, ENST00000690812, ENST00000692411, ENSP00000508541, ENST00000693325

PRO

P60880

Pharos - Targets

P60880

Orphanet

23214

HMDB Protein

HMDBP02940

PDB

3DDA, 3ZUR, 3RK2, 2N1T, 3DDB, 3RL0, 5W7I, 8BAN, 3RK3, 8BAV, 6JLH, 5W7J, 1KIL, 1XTG

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:O75558 STX11			0.553	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.547	3
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.527	2
UniProt:P84077 ARF1	2	ARF1 [cytosol] (R-HSA-200826) ARF1 [Golgi membrane] (R-HSA-199971)	0.512	5
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.502	2
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2