Reactome | EIF5A [cytosol]

EIF5A [cytosol]

Stable Identifier

R-HSA-3006308

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eukaryotic translation initiation factor 5A-1, IF5A1_HUMAN, Dhp50

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63241 EIF5A

Gene Names

EIF5A

Chain

initiator methionine:, chain:2-154

Reference Genes

BioGPS Gene:1984 EIF5A

COSMIC (genes):EIF5A EIF5A

CTD Gene:1984 EIF5A

dbSNP Gene:1984 EIF5A

ENSEMBL:ENSG00000132507 EIF5A

HGNC:3300 EIF5A

Monarch:1984 EIF5A

NCBI Gene:1984 EIF5A

OMIM:600187 EIF5A

UCSC:P63241 EIF5A

Reference Transcript

Other Identifiers

11737958_x_at

11744682_x_at

11753619_s_at

11758734_x_at

11761161_at

1984

201122_PM_x_at

201122_x_at

201123_PM_s_at

201123_s_at

213753_3p_x_at

213753_PM_x_at

213753_x_at

3253922

3253923

3253924

3253925

3253929

3253930

3253931

3253932

3297606

3297607

3297608

3297610

3708423

3708424

3708425

3708426

3708427

3708428

3708429

3708430

3708432

3708433

3708434

3708435

3708436

3708437

3708438

3708439

3708440

3708441

3708442

3708443

7928600

7928630

7934753

A_14_P127548

A_24_P31235

GE79692

GE88537

GO:0003723

GO:0003746

GO:0005515

GO:0005634

GO:0005642

GO:0005643

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006355

GO:0006412

GO:0006414

GO:0016020

GO:0017070

GO:0033209

GO:0043022

GO:0043226

GO:0045182

GO:0045901

GO:0045905

GO:0045944

GO:0098586

GO:1902255

HMNXSV003008002

Hs.119140.1.S1_3p_x_at

ILMN_1794522

S72024_s_at

TC17000088.hg

g4503544_3p_a_at

Participates

as a member of

EIF5A [cytosol] (Homo sapiens)

Other forms of this molecule

Dhp-K50-EIF5A [cytosol]

Hyp-K50-EIF5A [cytosol]

Inferred To

eEF5 [cytosol] (Drosophila melanogaster)

tif51b [cytosol] (Schizosaccharomyces pombe)

iff-2 [cytosol] (Caenorhabditis elegans)

tif51a [cytosol] (Schizosaccharomyces pombe)

iff-1 [cytosol] (Caenorhabditis elegans)

Eif5a [cytosol] (Mus musculus)

Eif5a [cytosol] (Rattus norvegicus)

EIF5A [cytosol] (Bos taurus)

EIF5A [cytosol] (Canis familiaris)

EIF5A [cytosol] (Gallus gallus)

EIF5A [cytosol] (Plasmodium falciparum)

EIF5A [cytosol] (Sus scrofa)

ANB1 [cytosol] (Saccharomyces cerevisiae)

Homologues of EIF5A [cytosol] (Caenorhabditis elegans)

Homologues of EIF5A [cytosol] (Schizosaccharomyces pombe)

eif5a [cytosol] (Danio rerio)

eif5a [cytosol] (Dictyostelium discoideum)

eif5a [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000132507

ENSEMBL

ENSP00000390677, ENSP00000499855, ENST00000673210, ENSP00000396073, ENST00000672765, ENSP00000458269, ENST00000673259, ENSP00000459611, ENSP00000500624, ENST00000573542, ENST00000576930, ENST00000416016, ENSP00000500669, ENSP00000336702, ENSP00000500847, ENST00000672250, ENST00000571955, ENST00000672755, ENST00000673304, ENST00000336452, ENST00000419711, ENSP00000500414, ENSP00000459196, ENSP00000500717, ENST00000336458, ENSP00000336776, ENST00000673099, ENSP00000499995

HPA

ENSG00000132507-EIF5A

PRO

P63241

Pharos - Targets

P63241

GlyGen

P63241

HMDB Protein

HMDBP02415

PDB

3CPF, 8A0E, 8Y0W, 5DLQ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6

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