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SMAD6 [cytosol]
Stable Identifier
R-HSA-3006350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mothers against decapentaplegic homolog 6, SMAD6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43541 SMAD6
Gene Names
SMAD6, MADH6
Chain
chain:1-496
Reference Genes
BioGPS Gene:4091 SMAD6
COSMIC (genes):SMAD6 SMAD6
CTD Gene:4091 SMAD6
dbSNP Gene:4091 SMAD6
ENSEMBL:ENSG00000137834 SMAD6
HGNC:6772 SMAD6
KEGG:hsa:4091 SMAD6
Monarch:4091 SMAD6
NCBI Gene:4091 SMAD6
OMIM:602931 SMAD6
UCSC:O43541 SMAD6
Reference Transcript
RefSeq:XM_054377916.1 SMAD6
RefSeq:XM_011521561.3 SMAD6
RefSeq:NM_005585.4 SMAD6
Participates
as a member of
I-SMAD [cytosol] (Homo sapiens)
as an output of
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
Inferred To
tag-68 [cytosol]
(Caenorhabditis elegans)
Smad6 [cytosol]
(Mus musculus)
Smad6 [cytosol]
(Rattus norvegicus)
SMAD6 [cytosol]
(Bos taurus)
SMAD6 [cytosol]
(Canis familiaris)
SMAD6 [cytosol]
(Gallus gallus)
SMAD6 [cytosol]
(Sus scrofa)
smad6b [cytosol]
(Danio rerio)
Dad [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_054233891.1
,
NP_005576.3
,
XP_011519863.1
ENSEMBL
ENST00000557916
,
ENSG00000137834
,
ENSP00000452955
,
ENST00000288840
,
ENSP00000288840
OpenTargets
ENSG00000137834
GeneCards
SMAD6
HPA
ENSG00000137834-SMAD6
PRO
O43541
Pharos - Targets
O43541
GlyGen
O43541
Orphanet
SMAD6
HMDB Protein
HMDBP14504
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51817 PRKX
1
PRKX [nucleoplasm]
(R-HSA-3222308)
0.633
5
UniProt:Q15797 SMAD1
4
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.567
4
UniProt:O43541 SMAD6
1
SMAD6 [cytosol]
(R-HSA-3006350)
0.508
2
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