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SHC3 [cytosol]
Stable Identifier
R-HSA-3006448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC-transforming protein 3, SHC3_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Homo sapiens)
RET interactors [cytosol] (Homo sapiens)
SHC3 [cytosol] (Homo sapiens)
RET interactors [cytosol] (Homo sapiens)
SHC3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
SHC binds to the activated TrkA receptor (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC3 [cytosol] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC3 [cytosol] (Homo sapiens)
SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
SHC3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92529 SHC3
Gene Names
SHC3, NSHC, SHCC
Chain
chain:1-594
Reference Genes
BioGPS Gene:53358 SHC3
COSMIC (genes):SHC3 SHC3
CTD Gene:53358 SHC3
dbSNP Gene:53358 SHC3
ENSEMBL:ENSG00000148082 SHC3
HGNC:18181 SHC3
KEGG:hsa:53358 SHC3
Monarch:53358 SHC3
NCBI Gene:53358 SHC3
OMIM:605263 SHC3
UCSC:Q92529 SHC3
Reference Transcript
RefSeq:NM_016848.5 SHC3
Other Identifiers
11754600_a_at
1511_at
17095566
206330_PM_s_at
206330_s_at
229824_PM_at
229824_at
243881_PM_at
243881_at
3213840
3213842
3213844
3213846
3213848
3213849
3213850
3213857
3213859
3213860
3213861
3213862
3213864
3213865
3213866
3213873
3213878
3213883
3213884
3213888
3213896
3213897
3213898
53358
62122_at
8162216
85095_at
A_23_P61406
A_24_P484322
A_32_P176036
A_33_P3216090
D84361_at
GE57349
GE806856
GO:0001784
GO:0005515
GO:0005575
GO:0005829
GO:0005886
GO:0007169
GO:0007173
GO:0007417
GO:0030971
GO:0035556
GO:0048856
HMNXSV003007332
Hs.254119.0.S1_3p_at
Hs.4257.0.A1_3p_at
ILMN_1770905
PH_hs_0009106
TC09001311.hg
TC09002636.hg
TC09002637.hg
g8394263_3p_s_at
Participates
as a member of
RET interactors [cytosol] (Homo sapiens)
SHC [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y-SHC3 [cytosol]
Inferred To
SHC3 [cytosol]
(Bos taurus)
SHC3 [cytosol]
(Canis familiaris)
SHC3 [cytosol]
(Gallus gallus)
SHC3 [cytosol]
(Sus scrofa)
Shc3 [cytosol]
(Mus musculus)
Shc3 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_058544.3
ENSEMBL
ENST00000375835
,
ENSP00000364995
OpenTargets
ENSG00000148082
HPA
ENSG00000148082-SHC3
PRO
Q92529
Pharos - Targets
Q92529
GlyGen
Q92529
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.675
5
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:P48556 PSMD8
2
PSMD8 [cytosol]
(R-HSA-68808)
PSMD8 [nucleoplasm]
(R-HSA-174318)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q86U10 ASPG
1
ASPG [cytosol]
(R-HSA-6797634)
0.556
3
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