Reactome | ITSN1 [cytosol]

ITSN1 [cytosol]

Stable Identifier

R-HSA-3006481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Intersectin-1, ITSN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P60880 SNAP25

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        EPHB binds ITSN1 (Homo sapiens)
        
        ITSN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15811 ITSN1

Gene Names

ITSN1, ITSN, SH3D1A

Chain

chain:1-1721

Reference Genes

BioGPS Gene:6453 ITSN1

COSMIC (genes):ITSN1 ITSN1

CTD Gene:6453 ITSN1

dbSNP Gene:6453 ITSN1

ENSEMBL:ENSG00000205726 ITSN1

HGNC:6183 ITSN1

KEGG:hsa:6453 ITSN1

Monarch:6453 ITSN1

NCBI Gene:6453 ITSN1

OMIM:602442 ITSN1

UCSC:Q15811 ITSN1

Reference Transcript

Participates

as a member of

as a candidate of

CDC42 GEFs [cytosol] (Homo sapiens)

as an input of

EPHB binds ITSN1 (Homo sapiens)

as a component of

Inferred To

Homologues of ITSN1 [cytosol] (Canis familiaris)

Homologues of ITSN1 [cytosol] (Plasmodium falciparum)

Homologues of ITSN1 [cytosol] (Saccharomyces cerevisiae)

Homologues of ITSN1 [cytosol] (Schizosaccharomyces pombe)

ITSN1 [cytosol] (Bos taurus)

ITSN1 [cytosol] (Canis familiaris)

ITSN1 [cytosol] (Gallus gallus)

ITSN1 [cytosol] (Mus musculus)

ITSN1 [cytosol] (Plasmodium falciparum)

ITSN1 [cytosol] (Rattus norvegicus)

ITSN1 [cytosol] (Saccharomyces cerevisiae)

ITSN1 [cytosol] (Schizosaccharomyces pombe)

ITSN1 [cytosol] (Sus scrofa)

Dap160 [cytosol] (Drosophila melanogaster)

LOC119867035 [cytosol] (Canis familiaris)

itsn-1 [cytosol] (Caenorhabditis elegans)

pan1 [cytosol] (Schizosaccharomyces pombe)

ucp8 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of ITSN1 [cytosol] (Danio rerio)

IRS4 [cytosol] (Saccharomyces cerevisiae)

end3 [cytosol] (Schizosaccharomyces pombe)

eps15 [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000205726

ENSEMBL

ENSP00000370691, ENST00000399367, ENST00000399353, ENST00000381318, ENST00000399352, ENSP00000382275, ENST00000381291, ENSP00000382290, ENSP00000370719, ENSG00000205726, ENSP00000382286, ENSP00000382289, ENST00000399338, ENST00000399349, ENSP00000382301

HPA

ENSG00000205726-ITSN1

GeneCards

ITSN1

PRO

Q15811

Pharos - Targets

Q15811

Orphanet

ITSN1

PDB

2KGR, 6H5T, 1KI1, 2KHN, 3FIA, 6GBU, 5HZK, 4IIM, 5HZJ, 5HZI, 3QBV

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63010 AP2B1	4	AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.764	5
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.738	5
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.729	12
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.722	8
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [Golgi membrane] (R-HSA-2980842)	0.713	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.704	5
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:Q05193 DNM1	3	DNM1 [plasma membrane] (R-HSA-177488) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [cytosol] (R-HSA-2213182)	0.623	3
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.573	2
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.564	3
UniProt:Q3UQN2	1	Fcho2 [cytosol] (R-MMU-8862260)	0.557	3
UniProt:Q12840 KIF5A	1	KIF5A [cytosol] (R-HSA-983190)	0.553	2
UniProt:P61968 LMO4			0.553	3
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.553	2
UniProt:Q9NRI5 DISC1			0.553	4
UniProt:P60953-1 CDC42			0.544	2
UniProt:P53680 AP2S1	4	AP2S1 [endolysosome membrane] (R-HSA-6784821) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [cytosol] (R-HSA-182197)	0.527	3
UniProt:P60880 SNAP25	7	SNAP25 [plasma membrane] (R-HSA-2029017) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-197) [plasma membrane] (R-HSA-3004546)	0.502	2