Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
KALRN [cytosol]
Stable Identifier
R-HSA-3006505
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kalirin, KALRN_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB2 binds KALRN (Homo sapiens)
EFNBs:p-EPHBs:KALRN [plasma membrane] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNBs:p-EPHBs:KALRN [plasma membrane] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPKAPK5 phosphorylates KALRN (Homo sapiens)
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GEFs activate RHOG (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
KALRN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60229 KALRN
Gene Names
KALRN, DUET, DUO, HAPIP, TRAD
Chain
chain:1-2986
Reference Genes
BioGPS Gene:8997 KALRN
COSMIC (genes):KALRN KALRN
CTD Gene:8997 KALRN
dbSNP Gene:8997 KALRN
ENSEMBL:ENSG00000160145 KALRN
HGNC:4814 KALRN
KEGG:hsa:8997 KALRN
Monarch:8997 KALRN
NCBI Gene:8997 KALRN
OMIM:604605 KALRN
UCSC:O60229 KALRN
Reference Transcript
RefSeq:NM_001322999.1 KALRN
RefSeq:NM_001323001.1 KALRN
RefSeq:NM_001024660.4 KALRN
RefSeq:NM_001323000.1 KALRN
RefSeq:NM_001322989.1 KALRN
RefSeq:NM_007064.4 KALRN
RefSeq:NM_001322996.1 KALRN
RefSeq:NM_001322998.1 KALRN
RefSeq:NM_001322997.1 KALRN
RefSeq:NM_003947.5 KALRN
RefSeq:NM_001322994.1 KALRN
RefSeq:NM_001322988.1 KALRN
RefSeq:NM_001322995.1 KALRN
Other Identifiers
11728160_at
11732547_a_at
11740771_a_at
11761443_a_at
16944798
16944912
205635_PM_at
205635_at
206078_PM_at
206078_at
227750_PM_at
227750_at
230596_PM_at
230596_at
236651_PM_at
236651_at
2639553
2639554
2639555
2639572
2639574
2639579
2639580
2639581
2639582
2639583
2639584
2639587
2639588
2639603
2639604
2639605
2639611
2639617
2639618
2639624
2639625
2639626
2639627
2639633
2639636
2639640
2639643
2639646
2639655
2639656
2639657
2639658
2639661
2639662
2639663
2639664
2639666
2639668
2639673
2639674
2639677
2639678
2639682
2639685
2639689
2639691
2639694
2639695
2639697
2639698
2639700
2639701
2639704
2639705
2639706
2639707
2639708
2639709
2639710
2639711
2639712
2639719
2639720
2639721
2639722
2639723
2639735
2639741
2639742
2639754
2639755
2639758
2639763
2639764
2639765
2639766
2639767
2639768
2639769
2639770
2639772
2639773
2639776
2639777
2639780
2639781
2639782
2639783
2639784
2639785
2639786
2639787
2639788
2639789
2639790
2639791
2639801
2639802
2639803
2639804
2639805
2639806
2639807
2639808
2639809
2639810
2639813
2639814
2639815
2639816
2639858
2639870
2639872
2639873
2639875
2639876
2639877
2639878
2639879
2639880
3378272
35406_at
40655_at
43143_at
55541_f_at
58195_at
60043_at
64267_f_at
75375_at
8082165
87055_at
8997
A_14_P101744
A_14_P108281
A_14_P115189
A_14_P133955
A_21_P0000554
A_23_P307563
A_24_P328524
A_24_P410797
A_32_P207481
A_33_P3219121
A_33_P3219138
GE59579
GE760573
GE80203
GE809710
GO:0003824
GO:0004672
GO:0004674
GO:0005085
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006468
GO:0007165
GO:0007399
GO:0007411
GO:0007528
GO:0007595
GO:0007613
GO:0008344
GO:0014069
GO:0015629
GO:0016192
GO:0016740
GO:0019898
GO:0022414
GO:0034330
GO:0035176
GO:0035556
GO:0042711
GO:0043226
GO:0046872
GO:0046959
GO:0048013
GO:0048856
GO:0050877
GO:0051056
GO:0060125
GO:0060137
GO:0061003
GO:0070062
GO:0098772
GO:0106310
GO:0140096
HMNXSV003014426
HMNXSV003028059
HMNXSV003034596
HMNXSV003056803
HMNXSV003058048
HMNXSV003058231
Hs.13281.0.A1_3p_at
Hs.143061.0.A1_3p_at
Hs.162189.1.S1_3p_at
ILMN_1804661
ILMN_1812233
ILMN_2241750
PH_hs_0000847
PH_hs_0001277
PH_hs_0008413
PH_hs_0009841
TC03000642.hg
TC03002503.hg
TC03002504.hg
g4504334_3p_at
g5902139_3p_at
p11946
p34371
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
RHOG GEFs [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as an input of
p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)
EPHB2 binds KALRN (Homo sapiens)
as a component of
KALRN:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:KALRN [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-KALRN [cytosol]
Inferred To
KALRN [cytosol]
(Canis familiaris)
KALRN [cytosol]
(Gallus gallus)
KALRN [cytosol]
(Mus musculus)
KALRN [cytosol]
(Rattus norvegicus)
trio [cytosol]
(Drosophila melanogaster)
unc-73 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001309923.1
,
NP_001309925.1
,
NP_001309924.1
,
NP_008995.2
,
NP_001309927.1
,
NP_001309926.1
,
NP_001309928.1
,
NP_001309917.1
,
NP_001309918.1
,
NP_001309929.1
,
NP_003938.1
,
NP_001019831.2
,
NP_001309930.1
Guide to Pharmacology - Targets
2050
OpenTargets
ENSG00000160145
ENSEMBL
ENST00000360013
,
ENSP00000291478
,
ENST00000240874
,
ENSP00000240874
,
ENSP00000353109
,
ENST00000291478
HPA
ENSG00000160145-KALRN
PRO
O60229
Pharos - Targets
O60229
GlyGen
O60229
PDB
5QU9
,
5QQK
,
5QQL
,
5QQG
,
5QQH
,
5QQD
,
5QQF
,
8C7D
,
5QQI
,
5QQJ
,
5QQE
,
5QQM
,
5QQN
HMDB Protein
HMDBP08472
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449633 REP
0.556
3
UniProt:P0DTD1-PRO_0000449631 REP
0.556
3
UniProt:Q9GZM8 NDEL1
1
NDEL1 [cytosol]
(R-HSA-376258)
0.553
2
UniProt:Q9NRI5 DISC1
0.553
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text