Reactome | LINGO1 [plasma membrane]

LINGO1 [plasma membrane]

Stable Identifier

R-HSA-3006563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, LIGO1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P14373 TRIM27

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External Reference Information

External Reference

UniProt:Q96FE5 LINGO1

Gene Names

LINGO1, LERN1, LRRN6A, UNQ201/PRO227

Chain

signal peptide:1-41, chain:42-620

Reference Genes

BioGPS Gene:84894 LINGO1

COSMIC (genes):LINGO1 LINGO1

CTD Gene:84894 LINGO1

dbSNP Gene:84894 LINGO1

ENSEMBL:ENSG00000169783 LINGO1

ENSEMBL:ENSG00000169783.13 LINGO1

HGNC:21205 LINGO1

KEGG Gene (Homo sapiens):84894 LINGO1

Monarch:84894 LINGO1

NCBI Gene:84894 LINGO1

OMIM:609791 LINGO1

UCSC:Q96FE5 LINGO1

Reference Transcript

Other Identifiers

11728336_a_at

11728337_x_at

16812014

227933_3p_at

227933_PM_at

227933_at

3634257

3634258

3634259

3634260

3634265

3634276

3634281

3634282

43915_at

62317_r_at

7990643

84894

A_19_P00317590

A_19_P00319519

A_23_P206092

A_24_P112941

A_33_P3399228

GE63380

GO:0005154

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0016020

GO:0030312

GO:0031012

HMNXSV003026618

HMNXSV003034518

HMNXSV003050395

Hs.24835.0.A1_3p_at

Hs.24835.0.A1_3p_x_at

ILMN_1756755

PH_hs_0032209

TC15001694.hg

Participates

as an input of

p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)

as a component of

NGFR:RTN4R:LINGO1 [plasma membrane] (Homo sapiens)

Inferred To

Fili [plasma membrane] (Drosophila melanogaster)

trn [plasma membrane] (Drosophila melanogaster)

Homologues of LINGO1 [plasma membrane] (Drosophila melanogaster)

lingo1 [plasma membrane] (Xenopus tropicalis)

Lingo1 [plasma membrane] (Mus musculus)

Lingo1 [plasma membrane] (Rattus norvegicus)

Dmel\CG7509 [plasma membrane] (Drosophila melanogaster)

LINGO1 [plasma membrane] (Bos taurus)

LINGO1 [plasma membrane] (Canis familiaris)

LINGO1 [plasma membrane] (Danio rerio)

LINGO1 [plasma membrane] (Sus scrofa)

lbk [plasma membrane] (Drosophila melanogaster)

Toll-7 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001288126.1, NP_001288116.1, NP_001288121.1, NP_001288127.1, NP_001288120.1, NP_001288118.1, NP_001288129.1, NP_001288128.1, XP_011520420.1, NP_116197.4, NP_001288124.1, NP_001288123.1, NP_001288115.1, XP_016878171.1

Guide to Pharmacology - Targets

2882

OpenTargets

ENSG00000169783

HPA

ENSG00000169783-LINGO1

GeneCards

Q96FE5

Ensembl

ENST00000561030, ENST00000355300, ENSP00000453853, ENSG00000169783, ENSP00000347451

PRO

Q96FE5

Pharos - Targets

Q96FE5

Orphanet

20672

PDB

4OQT, 2ID5

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08138 NGFR	7	NGFR [plasma membrane] (R-HSA-193664) NGFR(29-250) [extracellular region] (R-HSA-194470) NGFR(251-427) [plasma membrane] (R-HSA-194476) NGFR(251-427) [endosome] (R-HSA-209541) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(273-427) [nucleoplasm] (R-HSA-197473)	0.589	2
UniProt:Q96R06 SPAG5			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:Q9P121-3 NTM			0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q8N5G2 MACO1	1	MACO1 [endoplasmic reticulum membrane] (R-HSA-9714351)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:P23142-4 FBLN1			0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:Q99M75 RTN4R			0.544	2
UniProt:P05067-4 APP			0.524	2

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