Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
LINGO1 [plasma membrane]
Stable Identifier
R-HSA-3006563
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, LIGO1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9H2F3%20HSD3B7
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth inhibition (RHOA activation) (Homo sapiens)
p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)
LINGO1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FE5 LINGO1
Gene Names
LINGO1, LERN1, LRRN6A, UNQ201/PRO227
Chain
signal peptide:1-41, chain:42-620
Reference Genes
BioGPS Gene:84894 LINGO1
COSMIC (genes):LINGO1 LINGO1
CTD Gene:84894 LINGO1
dbSNP Gene:84894 LINGO1
ENSEMBL:ENSG00000169783 LINGO1
ENSEMBL_homo_sapiens_GENE:ENSG00000169783.13 LINGO1
HGNC:21205 LINGO1
KEGG Gene (Homo sapiens):84894 LINGO1
Monarch:84894 LINGO1
NCBI Gene:84894 LINGO1
OMIM:609791 LINGO1
UCSC:Q96FE5 LINGO1
Reference Transcript
RefSeq:NM_001301197.1 LINGO1
RefSeq:XM_011522118.2 LINGO1
RefSeq:NM_032808.6 LINGO1
RefSeq:NM_001301189.1 LINGO1
RefSeq:NM_001301187.1 LINGO1
RefSeq:NM_001301195.1 LINGO1
RefSeq:NM_001301186.1 LINGO1
RefSeq:NM_001301194.1 LINGO1
RefSeq:NM_001301200.1 LINGO1
RefSeq:NM_001301199.1 LINGO1
RefSeq:XM_017022682.1 LINGO1
RefSeq:NM_001301192.1 LINGO1
RefSeq:NM_001301191.1 LINGO1
RefSeq:NM_001301198.1 LINGO1
Other Identifiers
11728336_a_at
11728337_x_at
16812014
227933_3p_at
227933_PM_at
227933_at
3634257
3634258
3634259
3634260
3634265
3634276
3634281
3634282
43915_at
62317_r_at
7990643
84894
A_19_P00317590
A_19_P00319519
A_23_P206092
A_24_P112941
A_33_P3399228
GE63380
GO:0005154
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0016020
GO:0030312
GO:0031012
HMNXSV003026618
HMNXSV003034518
HMNXSV003050395
Hs.24835.0.A1_3p_at
Hs.24835.0.A1_3p_x_at
ILMN_1756755
PH_hs_0032209
TC15001694.hg
Participates
as an input of
p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)
as a component of
NGFR:RTN4R:LINGO1 [plasma membrane] (Homo sapiens)
Inferred To
Homologues of LINGO1 [plasma membrane]
(Danio rerio)
lingo1b [plasma membrane]
(Danio rerio)
Lingo1 [plasma membrane]
(Mus musculus)
Lingo1 [plasma membrane]
(Rattus norvegicus)
zgc:198379 [plasma membrane]
(Danio rerio)
LINGO1 [plasma membrane]
(Bos taurus)
LINGO1 [plasma membrane]
(Canis familiaris)
LINGO1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001288115.1
,
NP_001288116.1
,
NP_001288120.1
,
NP_001288124.1
,
NP_001288129.1
,
XP_016878171.1
,
NP_001288126.1
,
NP_001288118.1
,
NP_001288121.1
,
NP_001288127.1
,
NP_001288123.1
,
NP_116197.4
,
XP_011520420.1
,
NP_001288128.1
Guide to Pharmacology - Targets
2882
OpenTargets
ENSG00000169783
GeneCards
Q96FE5
HPA
ENSG00000169783-LINGO1
Ensembl
ENSP00000453853
,
ENST00000561030
,
ENST00000355300
,
ENSG00000169783
,
ENSP00000347451
PRO
Q96FE5
Pharos - Targets
Q96FE5
Orphanet
20672
PDB
2ID5
,
4OQT
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08138 NGFR
7
NGFR [plasma membrane]
(R-HSA-193664)
NGFR(29-250) [extracellular region]
(R-HSA-194470)
NGFR(251-427) [plasma membrane]
(R-HSA-194476)
NGFR(251-427) [endosome]
(R-HSA-209541)
NGFR(273-427) [cytosol]
(R-HSA-194458)
NGFR(251-272) [plasma membrane]
(R-HSA-194509)
NGFR(273-427) [nucleoplasm]
(R-HSA-197473)
0.589
2
UniProt:Q96R06 SPAG5
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q6L8G9 KRTAP5-6
1
KRTAP5-6 [cytosol]
(R-HSA-6810276)
0.556
3
UniProt:Q9P121-3 NTM
0.556
3
IntAct:EBI-16436789 CCSB ORF ID
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q8N5G2 MACO1
1
MACO1 [endoplasmic reticulum membrane]
(R-HSA-9714351)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:P23142-4 FBLN1
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:Q9H2F3 HSD3B7
1
HSD3B7 [endoplasmic reticulum membrane]
(R-HSA-193441)
0.556
3
UniProt:Q99M75 RTN4R
0.544
2
UniProt:P05067-4 APP
2
APP (535-695) [cytosol]
(R-HSA-9839084)
APP [mitochondrial inner membrane]
(R-HSA-9839060)
0.524
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text