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MAPKAP1 [cytosol]
Stable Identifier
R-HSA-3006620
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Target of rapamycin complex 2 subunit MAPKAP1, SIN1_HUMAN, Stress-activated map kinase interacting protein 1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant is phosphorylated by TORC2 complex (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
TORC2 complex phosphorylates SGK1 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
TORC2 complex phosphorylates SGK1 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
TORC2 complex [cytosol] (Homo sapiens)
MAPKAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BPZ7 MAPKAP1
Gene Names
MAPKAP1, MIP1, SIN1
Chain
initiator methionine:, chain:2-522
Reference Genes
BioGPS Gene:79109 MAPKAP1
COSMIC (genes):MAPKAP1 MAPKAP1
CTD Gene:79109 MAPKAP1
dbSNP Gene:79109 MAPKAP1
ENSEMBL:ENSG00000119487 MAPKAP1
HGNC:18752 MAPKAP1
KEGG:hsa:79109 MAPKAP1
Monarch:79109 MAPKAP1
NCBI Gene:79109 MAPKAP1
OMIM:610558 MAPKAP1
UCSC:Q9BPZ7 MAPKAP1
Reference Transcript
RefSeq:NM_001006618.1 MAPKAP1
RefSeq:NM_001006619.1 MAPKAP1
RefSeq:NM_024117.3 MAPKAP1
RefSeq:XM_017015126.1 MAPKAP1
RefSeq:NM_001006620.1 MAPKAP1
RefSeq:NM_001006621.1 MAPKAP1
RefSeq:XM_011519010.2 MAPKAP1
RefSeq:XM_017015127.1 MAPKAP1
RefSeq:NM_001006617.1 MAPKAP1
Other Identifiers
11719296_a_at
11719297_s_at
11719298_x_at
11723575_x_at
11726890_a_at
11748111_a_at
11748112_x_at
11751490_a_at
11756830_x_at
17098424
1906_at
217808_PM_s_at
217808_s_at
222426_PM_at
222426_at
229845_PM_at
229845_at
229846_PM_s_at
229846_s_at
3225457
3225458
3225459
3225463
3225464
3225467
3225468
3225476
3225478
3225479
3225481
3225482
3225483
3225489
3225490
3225491
3225499
3225508
3225509
3225510
3225511
3225518
3225519
3225521
3225524
3225525
3225526
3225527
3225534
3225535
3225536
3225537
3225538
3225539
3225540
3225541
3225546
3225549
46231_at
59749_at
65919_at
76321_at
79109
8164177
A_23_P216894
A_24_P43884
A_33_P3251538
A_33_P3397755
GE82806
GE87196
GE87197
GO:0005515
GO:0005546
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0007010
GO:0008289
GO:0019901
GO:0021762
GO:0030307
GO:0031267
GO:0031410
GO:0031669
GO:0031932
GO:0033138
GO:0038203
GO:0043066
GO:0043226
GO:0043325
GO:0046580
GO:0048856
GO:0060090
GO:0070300
GO:0080025
GO:1900407
HMNXSV003004216
HMNXSV003042668
Hs.324178.0.S2_3p_at
Hs.324178.1.S1_3p_at
ILMN_1691526
ILMN_2268068
ILMN_2360229
PH_hs_0016132
TC09002791.hg
g13129137_3p_a_at
p27774
Participates
as a component of
TORC2 complex [cytosol] (Homo sapiens)
Inferred To
sin1 [cytosol]
(Schizosaccharomyces pombe)
sinh-1 [cytosol]
(Caenorhabditis elegans)
ripA [cytosol]
(Dictyostelium discoideum)
AVO1 [cytosol]
(Saccharomyces cerevisiae)
MAPKAP1 [cytosol]
(Canis familiaris)
MAPKAP1 [cytosol]
(Gallus gallus)
MAPKAP1 [cytosol]
(Mus musculus)
MAPKAP1 [cytosol]
(Rattus norvegicus)
MAPKAP1 [cytosol]
(Sus scrofa)
Sin1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011517312.1
,
NP_001006622.1
,
XP_016870615.1
,
NP_001006620.1
,
NP_077022.1
,
NP_001006621.1
,
XP_016870616.1
,
NP_001006619.1
,
NP_001006618.1
OpenTargets
ENSG00000119487
ENSEMBL
ENST00000373503
,
ENSP00000377627
,
ENSP00000265960
,
ENSP00000265961
,
ENSG00000119487
,
ENST00000394063
,
ENST00000394060
,
ENSP00000377624
,
ENSP00000362602
,
ENST00000265960
,
ENSP00000362610
,
ENST00000350766
,
ENST00000373498
,
ENSP00000362597
,
ENST00000373511
HPA
ENSG00000119487-MAPKAP1
GeneCards
MAPKAP1
PRO
Q9BPZ7
Pharos - Targets
Q9BPZ7
GlyGen
Q9BPZ7
HMDB Protein
HMDBP02503
PDB
7PE9
,
7LC2
,
7PE8
,
7VVG
,
7LC1
,
7VVB
,
7PE7
,
3VOQ
,
7TZO
,
6ZWO
,
5ZCS
,
7VV8
,
7VV9
,
6ZWM
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.643
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:P78527 PRKDC
4
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.499
2
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