Reactome | MAPKAP1 [cytosol]

MAPKAP1 [cytosol]

Stable Identifier

R-HSA-3006620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Target of rapamycin complex 2 subunit MAPKAP1, SIN1_HUMAN, Stress-activated map kinase interacting protein 1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MAPKAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BPZ7 MAPKAP1

Gene Names

MAPKAP1, MIP1, SIN1

Chain

initiator methionine:1, chain:2-522

Reference Genes

BioGPS Gene:79109 MAPKAP1

COSMIC (genes):MAPKAP1 MAPKAP1

CTD Gene:79109 MAPKAP1

dbSNP Gene:79109 MAPKAP1

ENSEMBL:ENSG00000119487 MAPKAP1

HGNC:18752 MAPKAP1

KEGG Gene (Homo sapiens):79109 MAPKAP1

Monarch:79109 MAPKAP1

NCBI Gene:79109 MAPKAP1

OMIM:610558 MAPKAP1

UCSC:Q9BPZ7 MAPKAP1

Reference Transcript

Other Identifiers

0003610471

11719296_a_at

11719297_s_at

11719298_x_at

11723575_x_at

11726890_a_at

11748111_a_at

11748112_x_at

11751490_a_at

11756830_x_at

17098424

1906_at

217808_s_at

222426_at

229845_at

229846_s_at

3225457

3225458

3225459

3225464

3225476

3225482

3225491

3225499

3225511

3225519

3225524

3225537

3225538

3225539

3225540

3225541

3225549

46231_at

59749_at

65919_at

76321_at

79109

8164177

A_23_P216894

A_24_P43884

A_33_P3251538

A_33_P3397755

GE82806

GE87196

GE87197

GO:0003674

GO:0005515

GO:0005546

GO:0005547

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006464

GO:0006950

GO:0007010

GO:0007165

GO:0008150

GO:0008289

GO:0016020

GO:0016301

GO:0016310

GO:0019899

GO:0019901

GO:0021762

GO:0030950

GO:0031267

GO:0031410

GO:0031932

GO:0032148

GO:0032991

GO:0033138

GO:0038203

GO:0043167

GO:0043226

GO:0043325

GO:0046580

GO:0048856

GO:0070300

GO:0080025

GO:1900407

GO:1901796

HMNXSV003004216

HMNXSV003042668

Hs.324178.0.S2_3p_at

Hs.324178.1.S1_3p_at

ILMN_1691526

ILMN_1723142

ILMN_2268068

ILMN_2360229

PH_hs_0016132

TC09002791.hg

g13129137_3p_a_at

Participates

as a component of

TORC2 complex [cytosol] (Homo sapiens)

Inferred To

Mapkap1 [cytosol] (Mus musculus)

Mapkap1 [cytosol] (Rattus norvegicus)

sin1 [cytosol] (Schizosaccharomyces pombe)

sinh-1 [cytosol] (Caenorhabditis elegans)

mapkap1 [cytosol] (Danio rerio)

mapkap1 [cytosol] (Xenopus tropicalis)

ripA [cytosol] (Dictyostelium discoideum)

AVO1 [cytosol] (Saccharomyces cerevisiae)

MAPKAP1 [cytosol] (Canis familiaris)

MAPKAP1 [cytosol] (Gallus gallus)

MAPKAP1 [cytosol] (Sus scrofa)

Sin1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001006621.1, XP_016870616.1, NP_001006622.1, NP_001006618.1, NP_077022.1, NP_001006620.1, XP_011517312.1, NP_001006619.1, XP_016870615.1

OpenTargets

ENSG00000119487

HPA

ENSG00000119487-MAPKAP1

GeneCards

Q9BPZ7

Ensembl

ENST00000350766, ENSG00000119487, ENST00000373511, ENSP00000362610, ENST00000394063, ENST00000394060, ENSP00000362602, ENST00000373498, ENSP00000362597, ENSP00000265960, ENSP00000265961, ENST00000265960, ENSP00000377624, ENSP00000377627, ENST00000373503

PRO

Q9BPZ7

Pharos - Targets

Q9BPZ7

HMDB Protein

HMDBP02503

PDB

6ZWM, 3VOQ, 6ZWO, 5ZCS

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.499	2