Reactome | MAX [nucleoplasm]

MAX [nucleoplasm]

Stable Identifier

R-HSA-3006627

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein max, MAX_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61244 MAX

Gene Names

MAX, BHLHD4

Chain

initiator methionine:, chain:2-160, initiator methionine:

Reference Genes

BioGPS Gene:4149 MAX

COSMIC (genes):MAX MAX

CTD Gene:4149 MAX

dbSNP Gene:4149 MAX

ENSEMBL:ENSG00000125952 MAX

ENSEMBL_homo_sapiens_GENE:ENSG00000125952.21 MAX

HGNC:6913 MAX

KEGG Gene (Homo sapiens):4149 MAX

Monarch:4149 MAX

NCBI Gene:4149 MAX

OMIM:154950 MAX

UCSC:P61244 MAX

Reference Transcript

Other Identifiers

11728150_at

11729188_a_at

11729189_x_at

11729190_a_at

11729191_s_at

11733720_at

11733721_s_at

11733722_x_at

11740748_s_at

11754160_x_at

11759325_a_at

11762234_a_at

16793901

1981_s_at

208403_PM_x_at

208403_x_at

209331_PM_s_at

209331_s_at

209332_PM_s_at

209332_s_at

210734_PM_x_at

210734_x_at

214108_PM_at

214108_at

3568668

3568677

3568678

3568679

3568680

3568681

3568682

3568683

3568684

3568685

3568686

3568687

3568688

3568693

3568694

3568695

3568698

3568703

3568706

3568707

39948_at

4149

422_s_at

50228_at

63606_at

713_at

7979671

A_23_P151662

A_23_P205549

A_23_P436138

GE59858

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0030425

GO:0032993

GO:0042802

GO:0042995

GO:0043226

GO:0045893

GO:0045944

GO:0046983

GO:0070443

GO:0070888

GO:0071339

GO:0071943

GO:0090575

GO:0140110

GO:0140297

GO:1990837

HMNXSV003005455

HMNXSV003030625

HMNXSV003048972

Hs.42712.1.S1_3p_a_at

Hs.42712.3.S1_3p_at

ILMN_1695633

ILMN_1704236

ILMN_1706546

ILMN_1802457

ILMN_2363426

PH_hs_0003126

PH_hs_0031184

TC14001225.hg

X66867_cds1_at

g13097617_3p_a_at

g187390_3p_a_at

g4505114_3p_x_at

p33672

p33673

Participates

as a component of

Inferred To

MAX [nucleoplasm] (Bos taurus)

MAX [nucleoplasm] (Canis familiaris)

MAX [nucleoplasm] (Gallus gallus)

MAX [nucleoplasm] (Sus scrofa)

Max [nucleoplasm] (Drosophila melanogaster)

Max [nucleoplasm] (Mus musculus)

Max [nucleoplasm] (Rattus norvegicus)

mxl-3 [nucleoplasm] (Caenorhabditis elegans)

max [nucleoplasm] (Danio rerio)

max [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002373.3, NP_660088.1, NP_660089.1, NP_932061.1, NP_660087.1, NP_001257997.1

OpenTargets

ENSG00000125952

HPA

ENSG00000125952-MAX

GeneCards

P61244

Ensembl

ENSG00000125952, ENST00000553928, ENST00000284165, ENSP00000342482, ENST00000341653, ENSP00000284165, ENST00000246163, ENST00000394606, ENSP00000452378, ENSP00000451907, ENST00000556979, ENST00000358664, ENSP00000351175, ENSP00000246163, ENST00000358402, ENSP00000351490, ENSP00000378104

ZINC target

P61244

PRO

P61244

Pharos - Targets

P61244

Orphanet

20780

PDB

8OTS, 6G6L, 6G6J, 1NKP, 6G6K, 8OTT, 1R05, 1AN2, 5EYO, 1NLW, 1HLO

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.982	50
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.844	10
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.803	8
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.773	7
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.708	6
UniProt:Q14582 MXD4	1	MXD4 [nucleoplasm] (R-HSA-9612293)	0.643	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	5
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.527	2
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.508	2
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.499	2
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.499	2