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RHOT1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-3006728
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitochondrial Rho GTPase 1, MIRO1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
USP30:MOM proteins [mitochondrial outer membrane] (Homo sapiens)
MOM proteins [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Miro GTPase Cycle (Homo sapiens)
RHOT1 GTPase cycle (Homo sapiens)
RHOT1 GEFs activate RHOT1 (Homo sapiens)
RHOT1:GDP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
RHOT1 binds effectors at the mitochondrial outer membrane (Homo sapiens)
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
RHOT1:GTP:RHOT1 effectors [mitochondrial outer membrane] (Homo sapiens)
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
RHOT1 hydrolyzes GTP (Homo sapiens)
RHOT1:GDP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
RHOT1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IXI2 RHOT1
Gene Names
RHOT1, ARHT1
Chain
chain:1-618
Reference Genes
BioGPS Gene:55288 RHOT1
COSMIC (genes):RHOT1 RHOT1
CTD Gene:55288 RHOT1
dbSNP Gene:55288 RHOT1
ENSEMBL:ENSG00000126858 RHOT1
HGNC:21168 RHOT1
Monarch:55288 RHOT1
NCBI Gene:55288 RHOT1
OMIM:613888 RHOT1
UCSC:Q8IXI2 RHOT1
Reference Transcript
RefSeq:NM_001033568.2 RHOT1
RefSeq:NM_001288754.1 RHOT1
RefSeq:NM_018307.4 RHOT1
RefSeq:NM_001033567.2 RHOT1
RefSeq:NM_001288755.1 RHOT1
RefSeq:NM_001033566.2 RHOT1
RefSeq:NM_001288758.1 RHOT1
Other Identifiers
11740379_s_at
11756578_a_at
16833082
218323_PM_at
218323_at
222148_PM_s_at
222148_s_at
224044_PM_at
224044_at
3503428
3503429
3503431
3503433
3717540
3717541
3717542
3717545
3717546
3717548
3717549
3717550
3717551
3717555
3717556
3717558
3717559
3717560
3717561
3717562
3717563
3717564
3717565
3717566
3717567
3717568
3717569
3717570
3717572
3717573
3717574
3717575
3717576
3717577
3717578
3717579
3717580
3717581
3717584
3717585
3717588
3717589
3717590
3717591
3717592
3717593
3717594
3717595
3717599
3717601
3925288
3925290
55288
8006345
91428_at
A_14_P123761
A_23_P433204
A_24_P59765
A_33_P3326530
A_33_P3668049
GE55955
GO:0000166
GO:0003674
GO:0003824
GO:0003924
GO:0005509
GO:0005515
GO:0005525
GO:0005739
GO:0005741
GO:0007005
GO:0007018
GO:0007264
GO:0010821
GO:0016020
GO:0016787
GO:0019725
GO:0043226
GO:0046872
GO:0047497
GO:0061024
GO:0097345
HMNXSV003001605
HMNXSV003029455
HMNXSV003031160
Hs.14202.2.S1_3p_a_at
ILMN_1678504
ILMN_1731484
ILMN_1785762
ILMN_2338480
PH_hs_0001355
PH_hs_0038716
TC17000373.hg
g12053352_3p_at
g8922837_3p_at
Participates
as a component of
RHOT1:GDP [mitochondrial outer membrane] (Homo sapiens)
RHOT1:GTP [mitochondrial outer membrane] (Homo sapiens)
as a member of
MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
PolyUb-RHOT1 [mitochondrial outer membrane]
Inferred To
RHOT1 [mitochondrial outer membrane]
(Bos taurus)
RHOT1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
RHOT1 [mitochondrial outer membrane]
(Canis familiaris)
RHOT1 [mitochondrial outer membrane]
(Danio rerio)
RHOT1 [mitochondrial outer membrane]
(Dictyostelium discoideum)
RHOT1 [mitochondrial outer membrane]
(Drosophila melanogaster)
RHOT1 [mitochondrial outer membrane]
(Gallus gallus)
RHOT1 [mitochondrial outer membrane]
(Mus musculus)
RHOT1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
RHOT1 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
RHOT1 [mitochondrial outer membrane]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000126858
ENSEMBL
ENST00000581031
,
ENSP00000462669
,
ENST00000581094
,
ENSP00000378184
,
ENSP00000439737
,
ENST00000394692
,
ENSP00000334724
,
ENSP00000464094
,
ENST00000358365
,
ENST00000545287
,
ENST00000333942
,
ENSP00000351132
HPA
ENSG00000126858-RHOT1
PRO
Q8IXI2
Pharos - Targets
Q8IXI2
GlyGen
Q8IXI2
PDB
5KTY
,
5KSO
,
5KSP
,
5KU1
,
6D71
,
5KSY
,
5KSZ
HMDB Protein
HMDBP10639
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00410 IPO5
1
IPO5 [nucleoplasm]
(R-HSA-192675)
0.527
2
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.524
3
UniProt:Q9BXM7 PINK1
5
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
0.524
3
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