Reactome | RBPJ [nucleoplasm]

RBPJ [nucleoplasm]

Stable Identifier

R-HSA-3008668

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Recombining binding protein suppressor of hairless, SUH_HUMAN, CBF1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06330 RBPJ

Gene Names

RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH

Chain

chain:1-500

Reference Genes

BioGPS Gene:3516 RBPJ

COSMIC (genes):RBPJ RBPJ

CTD Gene:3516 RBPJ

dbSNP Gene:3516 RBPJ

ENSEMBL:ENSG00000168214 RBPJ

HGNC:5724 RBPJ

KEGG:hsa:3516 RBPJ

Monarch:3516 RBPJ

NCBI Gene:3516 RBPJ

OMIM:147183 RBPJ

UCSC:Q06330 RBPJ

Reference Transcript

Participates

as a component of

as an input of

Inferred To

RBPJ [nucleoplasm] (Bos taurus)

RBPJ [nucleoplasm] (Canis familiaris)

RBPJ [nucleoplasm] (Gallus gallus)

RBPJ [nucleoplasm] (Sus scrofa)

lag-1 [nucleoplasm] (Caenorhabditis elegans)

cbf11 [nucleoplasm] (Schizosaccharomyces pombe)

rbpj [nucleoplasm] (Xenopus tropicalis)

rbpjb [nucleoplasm] (Danio rerio)

Su(H) [nucleoplasm] (Drosophila melanogaster)

Rbpj [nucleoplasm] (Mus musculus)

Rbpj [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_976028.1, NP_976029.1, NP_056958.3, XP_016863663.1, XP_016863664.1, XP_016863661.1, XP_016863662.1, XP_005248218.1, NP_005340.2, XP_011512142.1

OpenTargets

ENSG00000168214

ENSEMBL

ENST00000361572, ENSP00000504964, ENST00000348160, ENSP00000505636, ENST00000355476, ENST00000681264, ENST00000681484, ENST00000345843, ENST00000507561, ENST00000680928, ENSP00000340124, ENSP00000305815, ENSP00000354528, ENSP00000426872, ENSP00000347659, ENST00000342320, ENSG00000168214, ENST00000505958, ENSP00000421804, ENST00000681093, ENSP00000423644, ENST00000504423, ENSP00000505255, ENSP00000339699, ENST00000342295, ENSP00000423907, ENST00000512671, ENSP00000505493, ENSP00000345206

GeneCards

RBPJ

HPA

ENSG00000168214-RBPJ

PRO

Q06330

Pharos - Targets

Q06330

GlyGen

Q06330

Orphanet

RBPJ

PDB

2F8X, 3V79, 6PY8, 3NBN

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.913	13
UniProt:Q92585 MAML1	1	MAML1 [nucleoplasm] (R-HSA-212416)	0.892	8
UniProt:Q96K30 RITA1			0.729	10
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.688	3
UniProt:P12977 EBNA3			0.646	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.645	5
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.643	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.641	4
UniProt:P54253 ATX1			0.641	7
UniProt:P0C7T5 ATX1L			0.641	7
UniProt:Q6P3S6 FBX42			0.623	5
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.621	3
UniProt:Q01705 Notch1	20	Notch1 [endosome membrane] (R-MMU-9793910) p-NICD1 [nucleoplasm] (R-MMU-2064842) NICD1 [cytosol] (R-MMU-205738) N1' [plasma membrane] (R-MMU-206107) NTM' [extracellular region] (R-MMU-206219) NEXT1 [plasma membrane] (R-MMU-205889) NdeltaE [plasma membrane] (R-MMU-2063913) Fringe-modified NECD1 [plasma membrane] (R-MMU-2053928) Glc,GlcNAc-Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023154) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-MMU-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-MMU-1911511) NTM [plasma membrane] (R-MMU-206117) Notch1 Extracellular Domain (NECD1) [extracellular region] (R-MMU-2032285) Glc,Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023160) Glc,Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-2023167) Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-1985704) NICD1 [nucleoplasm] (R-MMU-157939) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-MMU-1983670) NOTCH1(1665-2555) [plasma membrane] (R-MMU-157239) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-MMU-1911512)	0.611	3
UniProt:P0CJ62 RITA1			0.544	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) NOTCH3(1572-2321) [Golgi membrane] (R-HSA-156995) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) NICD3 [nucleoplasm] (R-HSA-157928) NICD3 [cytosol] (R-HSA-157647) NEXT3 [plasma membrane] (R-HSA-157203) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517)	0.527	2
UniProt:Q9NW82 WDR70	1	WDR70 [nucleoplasm] (R-HSA-9770425)	0.527	2
UniProt:P03203 EBNA4			0.524	4
UniProt:P03204 EBNA6			0.524	3
UniProt:P12978 EBNA2			0.524	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.508	2
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.499	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.499	2

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