Reactome | NTRK1 [plasma membrane]

NTRK1 [plasma membrane]

Stable Identifier

R-HSA-3008784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

High affinity nerve growth factor receptor, NTRK1_HUMAN

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External Reference Information

External Reference

UniProt:P04629 NTRK1

Gene Names

NTRK1, MTC, TRK, TRKA

Chain

signal peptide:1-32, chain:33-796

Reference Genes

COSMIC (genes):NTRK1 NTRK1

dbSNP Gene:4914 NTRK1

ENSEMBL:ENSG00000198400 NTRK1

Participates

as an input of

as a component of

Other forms of this molecule

p-5Y-NTRK1 [Golgi membrane]

NTRK1 [Golgi membrane]

p-5Y-NTRK1 [plasma membrane]

Inferred To

NTRK1 [plasma membrane] (Bos taurus)

NTRK1 [plasma membrane] (Canis familiaris)

NTRK1 [plasma membrane] (Gallus gallus)

NTRK1 [plasma membrane] (Mus musculus)

NTRK1 [plasma membrane] (Rattus norvegicus)

NTRK1 [plasma membrane] (Sus scrofa)

NTRK1 [plasma membrane] (Xenopus tropicalis)

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01138 NGF	7	NGF [Golgi lumen] (R-HSA-166515) NGF(19-241) [extracellular region] (R-HSA-187033) NGF [cytosol] (R-HSA-190059) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF [extracellular region] (R-HSA-167034)	0.683	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.624	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.624	4
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.621	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.604	3
UniProt:P01138-PRO_0000019600 NGF			0.544	2
UniProt:Q8K4V6 Q8K4V6			0.524	2
UniProt:P05067-4 APP	2	APP (535-695) [cytosol] (R-HSA-9839084) APP [mitochondrial inner membrane] (R-HSA-9839060)	0.508	7
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.499	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.499	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.499	2
UniProt:Q99523 SORT1	2	SORT1 [Golgi membrane] (R-HSA-434332) SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221)	0.463	3
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.462	2

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