Reactome | p-5Y-NTRK1 [Golgi membrane]

p-5Y-NTRK1 [Golgi membrane]

Stable Identifier

R-HSA-3008810

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

p-NTRK1, High affinity nerve growth factor receptor, NTRK1_HUMAN, NTRK1

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External Reference Information

External Reference

UniProt:P04629 NTRK1

Gene Names

NTRK1, MTC, TRK, TRKA

Chain

signal peptide:1-32, chain:33-796

Reference Genes

BioGPS Gene:4914 NTRK1

COSMIC (genes):NTRK1 NTRK1

CTD Gene:4914 NTRK1

dbSNP Gene:4914 NTRK1

ENSEMBL:ENSG00000198400 NTRK1

HGNC:8031 NTRK1

KEGG:hsa:4914 NTRK1

Monarch:4914 NTRK1

NCBI Gene:4914 NTRK1

OMIM:191315 NTRK1

UCSC:P04629 NTRK1

Reference Transcript

Participates

as a member of

p-5Y-NTRK1, p-5Y-NTRK2 [Golgi membrane] (Homo sapiens)

Other forms of this molecule

p-5Y-NTRK1 [plasma membrane]

NTRK1 [plasma membrane]

NTRK1 [Golgi membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 496

Coordinate

496

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 676

Coordinate

676

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 680

Coordinate

680

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 681

Coordinate

681

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 791

Coordinate

791

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002520.2, NP_001012331.1, NP_001007793.1

Guide to Pharmacology - Targets

1817

OpenTargets

ENSG00000198400

ENSEMBL

ENST00000368196, ENST00000524377, ENSG00000198400, ENSP00000357179, ENSP00000431418

ZINC - FDA approved

NTRK1_HUMAN

ZINC - Substances

NTRK1_HUMAN

ZINC - Biogenic

NTRK1_HUMAN

ZINC target

P04629

PRO

P04629

GlyGen

P04629

PDB

4YNE, 6D1Z, 7XAF, 6PL1, 4GT5, 4PMM, 6D22, 6J5L, 4CRP, 7VKN, 5JFW, 6NPT, 8J5W, 7VKM, 5JFV, 8J63, 1WWW, 5KMK, 6DKW, 5KMM, 6DKG, 6NSS, 2N90, 6PMB, 5KVT, 6PL3, 6PMC, 5KMJ, 5JFS, 8YTD, 4PMS, 6D1Y, 4YPS, 5WR7, 5I8A, 7XBI, 6NSP, 1WWA, 6D20, 1HE7, 1SHC, 4PMP, 5JFX, 4AOJ, 5KMN, 7VKO, 8J61, 5KML, 7N3T, 2IFG, 6DKI, 6DKB, 8J5X, 4F0I, 6IQN, 6PMA, 6PME, 6PL2, 5H3Q, 6PL4, 4PMT, 5KMI, 5KMO, 8YTE

ZINC - Investigational

NTRK1_HUMAN

HPA

ENSG00000198400-NTRK1

GeneCards

NTRK1

Pharos - Targets

P04629

Orphanet

NTRK1

ZINC - Predictions - Purchasable

NTRK1_HUMAN

HMDB Protein

HMDBP01503

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01138 NGF	7	NGF [extracellular region] (R-HSA-167034) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF [cytosol] (R-HSA-190059) NGF [Golgi lumen] (R-HSA-166515) NGF(19-241) [extracellular region] (R-HSA-187033)	0.683	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.624	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.624	4
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.621	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.604	3
UniProt:P01138-PRO_0000019600 NGF			0.544	2
UniProt:Q8K4V6 Q8K4V6			0.524	2
UniProt:P05067-4 APP	2	APP [mitochondrial inner membrane] (R-HSA-9839060) APP (535-695) [cytosol] (R-HSA-9839084)	0.508	7
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.499	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.499	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.499	2
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.463	3
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.462	2

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