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PPP2R5D [cytosol]
Stable Identifier
R-HSA-3008950
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, 2A5D_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by AXIN mutants (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by GSK3beta mutants (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM-1 binds PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-PECAM:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A binds CTLA4 dimer (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 homodimer binds B7-1 homodimer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
CD28 homodimer binds B7-2 monomer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)
Inactive PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Association of beta-catenin with the destruction complex (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
Phosphorylation of APC component of the destruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5D [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14738 PPP2R5D
Gene Names
PPP2R5D
Chain
chain:1-602
Reference Genes
BioGPS Gene:5528 PPP2R5D
COSMIC (genes):PPP2R5D PPP2R5D
CTD Gene:5528 PPP2R5D
dbSNP Gene:5528 PPP2R5D
ENSEMBL:ENSG00000112640 PPP2R5D
HGNC:9312 PPP2R5D
KEGG:hsa:5528 PPP2R5D
Monarch:5528 PPP2R5D
NCBI Gene:5528 PPP2R5D
OMIM:601646 PPP2R5D
UCSC:Q14738 PPP2R5D
Reference Transcript
RefSeq:NM_001270476.1 PPP2R5D
RefSeq:NM_006245.3 PPP2R5D
RefSeq:NM_180977.2 PPP2R5D
RefSeq:NM_180976.2 PPP2R5D
Other Identifiers
11719794_a_at
11719795_a_at
11719796_x_at
11749173_a_at
11752412_a_at
17008728
202513_PM_s_at
202513_s_at
211159_PM_s_at
211159_s_at
2907539
2907540
2907541
2907545
2907546
2907547
2907548
2907549
2907550
2907552
2907553
2907554
2907555
2907556
2907557
2907558
2907559
2907560
2907561
2907562
2907563
2907564
2907565
2907566
2907567
2907569
39068_at
5528
8119627
A_14_P110643
A_24_P294931
GE57792
GO:0000159
GO:0003824
GO:0004721
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006470
GO:0007165
GO:0007399
GO:0016787
GO:0019888
GO:0035307
GO:0043226
GO:0048856
GO:0072542
GO:0098772
GO:0140096
HMNXSV003044004
ILMN_1699384
ILMN_1780940
ILMN_2359887
L76702_at
PH_hs_0006503
TC06000591.hg
g2189948_3p_a_at
g5453953_3p_a_at
Participates
as a component of
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
Inactive PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
as a candidate of
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
Other forms of this molecule
PPP2R5D [nucleoplasm]
Inferred To
PPP2R5D [cytosol]
(Bos taurus)
PPP2R5D [cytosol]
(Canis familiaris)
PPP2R5D [cytosol]
(Gallus gallus)
PPP2R5D [cytosol]
(Sus scrofa)
Ppp2r5d [cytosol]
(Mus musculus)
Ppp2r5d [cytosol]
(Rattus norvegicus)
pptr-2 [cytosol]
(Caenorhabditis elegans)
psrA [cytosol]
(Dictyostelium discoideum)
wrd [cytosol]
(Drosophila melanogaster)
RTS1 [cytosol]
(Saccharomyces cerevisiae)
par2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_006236.1
,
NP_001257405.1
,
NP_851308.1
,
NP_851307.1
ENSEMBL
ENSP00000420674
,
ENST00000485511
,
ENST00000461010
,
ENSP00000417963
,
ENST00000394110
,
ENSP00000377669
OpenTargets
ENSG00000112640
HPA
ENSG00000112640-PPP2R5D
PRO
Q14738
Pharos - Targets
Q14738
GlyGen
Q14738
Orphanet
PPP2R5D
PDB
8U1X
,
8U89
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.864
8
UniProt:P30307 CDC25C
8
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
CDC25C [cytosol]
(R-HSA-157879)
CDC25C [nucleoplasm]
(R-HSA-69741)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
0.589
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
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