Reactome | PGR [nucleoplasm]

PGR [nucleoplasm]

Stable Identifier

R-HSA-3008952

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Progesterone receptor, Nuclear receptor subfamily 3 group C member 3, NR3C3, PR

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)
        
        PGR [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06401 PGR

Gene Names

PGR, NR3C3

Chain

chain:1-933

Reference Genes

BioGPS Gene:5241 PGR

COSMIC (genes):PGR PGR

CTD Gene:5241 PGR

dbSNP Gene:5241 PGR

ENSEMBL:ENSG00000082175 PGR

HGNC:8910 PGR

KEGG:hsa:5241 PGR

Monarch:5241 PGR

NCBI Gene:5241 PGR

OMIM:607311 PGR

UCSC:P06401 PGR

Reference Transcript

Participates

as an input of

PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)

as a component of

PGR:P4 [nucleoplasm] (Homo sapiens)

as a member of

NR [nucleoplasm] (Homo sapiens)

as an output of

PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)

Other forms of this molecule

PGR [cytosol]

monoSUMO1-K7,K388,K531-PGR [nucleoplasm]

Inferred To

knrl [nucleoplasm] (Drosophila melanogaster)

pgr [nucleoplasm] (Danio rerio)

ERR [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PGR [nucleoplasm] (Plasmodium falciparum)

kni [nucleoplasm] (Drosophila melanogaster)

PGR [nucleoplasm] (Bos taurus)

PGR [nucleoplasm] (Canis familiaris)

PGR [nucleoplasm] (Gallus gallus)

PGR [nucleoplasm] (Mus musculus)

PGR [nucleoplasm] (Rattus norvegicus)

PGR [nucleoplasm] (Sus scrofa)

Homologues of PGR [nucleoplasm] (Canis familiaris)

Homologues of PGR [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

627

OpenTargets

ENSG00000082175

ENSEMBL

ENST00000534013, ENST00000263463, ENSP00000263463, ENSG00000082175, ENST00000325455, ENSP00000436561, ENSP00000325120

ZINC - FDA approved

PRGR_HUMAN

ZINC - Substances

PRGR_HUMAN

ZINC - Biogenic

PRGR_HUMAN

ZINC target

P06401

PRO

P06401

GlyGen

P06401

PDB

1SR7, 3D90, 4A2J, 4OAR, 3KBA, 3ZRB, 1SQN, 2C7A, 3HQ5, 5CC0, 2OVH, 3ZRA, 1ZUC, 1A28, 3G8O, 2OVM, 2W8Y, 4APU, 1E3K, 3ZR7

ZINC - Investigational

PRGR_HUMAN

ZINC - Metabolites

PRGR_HUMAN

HPA

ENSG00000082175-PGR

GeneCards

PGR

Pharos - Targets

P06401

ZINC - Predictions - Purchasable

PRGR_HUMAN

HMDB Protein

HMDBP01681

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.774	20
UniProt:Q9H467 CUED2			0.66	9
UniProt:P06401 PGR	3	PGR [nucleoplasm] (R-HSA-3008952) PGR [cytosol] (R-HSA-8948964) monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032)	0.623	2
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.623	3
IntAct:EBI-2119323 CCND1			0.527	5
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.462	2

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