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PPP2R5D [nucleoplasm]
Stable Identifier
R-HSA-3008956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, 2A5D_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 568) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
ERKs are inactivated by protein phosphatase 2A (Homo sapiens)
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
PPP2R5D [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14738 PPP2R5D
Gene Names
PPP2R5D
Chain
chain:1-602
Reference Genes
BioGPS Gene:5528 PPP2R5D
COSMIC (genes):PPP2R5D PPP2R5D
CTD Gene:5528 PPP2R5D
dbSNP Gene:5528 PPP2R5D
ENSEMBL:ENSG00000112640 PPP2R5D
HGNC:9312 PPP2R5D
KEGG Gene (Homo sapiens):5528 PPP2R5D
Monarch:5528 PPP2R5D
NCBI Gene:5528 PPP2R5D
OMIM:601646 PPP2R5D
UCSC:Q14738 PPP2R5D
Reference Transcript
RefSeq:NM_180977.2 PPP2R5D
RefSeq:NM_001270476.1 PPP2R5D
RefSeq:NM_180976.2 PPP2R5D
RefSeq:NM_006245.3 PPP2R5D
Other Identifiers
0005860402
11719794_a_at
11719795_a_at
11719796_x_at
11749173_a_at
11752412_a_at
17008728
202513_s_at
211159_s_at
2907539
2907540
2907541
2907546
2907547
2907548
2907549
2907550
2907552
2907553
2907554
2907556
2907557
2907558
2907560
2907561
2907562
2907563
2907564
2907566
2907567
39068_at
5528
8119627
A_14_P110643
A_24_P294931
GE57792
GO:0000159
GO:0003674
GO:0004721
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006470
GO:0007165
GO:0007399
GO:0008150
GO:0010801
GO:0016791
GO:0019888
GO:0030234
GO:0031952
GO:0032991
GO:0035307
GO:0043226
GO:0043666
GO:0048856
GO:0050790
GO:0072542
HMNXSV003044004
ILMN_1780940
ILMN_2359887
L76702_at
PH_hs_0006503
TC06000591.hg
g2189948_3p_a_at
g5453953_3p_a_at
Participates
as a component of
PP2A-ABdeltaC complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PPP2R5D [cytosol]
Inferred To
PPP2R5D [nucleoplasm]
(Bos taurus)
PPP2R5D [nucleoplasm]
(Canis familiaris)
Ppp2r5d [nucleoplasm]
(Mus musculus)
Ppp2r5d [nucleoplasm]
(Rattus norvegicus)
ppp2r5d [nucleoplasm]
(Danio rerio)
psrA [nucleoplasm]
(Dictyostelium discoideum)
par1 [nucleoplasm]
(Schizosaccharomyces pombe)
pptr-2 [nucleoplasm]
(Caenorhabditis elegans)
wrd [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001257405.1
,
NP_006236.1
,
NP_851308.1
,
NP_851307.1
OpenTargets
ENSG00000112640
HPA
ENSG00000112640-PPP2R5D
GeneCards
Q14738
Ensembl
ENST00000394110
,
ENSP00000417963
,
ENST00000485511
,
ENSG00000112640
,
ENSP00000420674
,
ENSP00000377669
,
ENST00000461010
PRO
Q14738
Pharos - Targets
Q14738
GlyGen
Q14738
Orphanet
23798
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30307 CDC25C
8
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
CDC25C [nucleoplasm]
(R-HSA-69741)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
CDC25C [cytosol]
(R-HSA-157879)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
0.589
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
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