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PEX19 [cytosol]
Stable Identifier
R-HSA-3009036
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peroxisomal biogenesis factor 19, PEX19_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q7Z412 PEX26
Expand all
Protein localization (Homo sapiens)
Class I peroxisomal membrane protein import (Homo sapiens)
PEX16:PEX19:PEX3 dissociates (Homo sapiens)
PEX19 [cytosol] (Homo sapiens)
PEX19 binds PEX3 (Homo sapiens)
PEX19 [cytosol] (Homo sapiens)
PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)
PEX19 [cytosol] (Homo sapiens)
PEX3:PEX19:class I PMP dissociates (Homo sapiens)
PEX19 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)
PEX19 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40855 PEX19
Gene Names
PEX19, HK33, PXF, OK/SW-cl.22
Chain
initiator methionine:, chain:2-296, propeptide:297-299
Reference Genes
BioGPS Gene:5824 PEX19
COSMIC (genes):PEX19 PEX19
CTD Gene:5824 PEX19
dbSNP Gene:5824 PEX19
ENSEMBL:ENSG00000162735 PEX19
HGNC:9713 PEX19
KEGG:hsa:5824 PEX19
Monarch:5824 PEX19
NCBI Gene:5824 PEX19
OMIM:600279 PEX19
UCSC:P40855 PEX19
Reference Transcript
RefSeq:NM_002857.3 PEX19
RefSeq:NM_001193644.1 PEX19
Other Identifiers
11732123_a_at
11732124_a_at
11733124_a_at
11733125_a_at
16695321
201706_PM_s_at
201706_s_at
201707_PM_at
201707_at
2440118
2440119
2440120
2440121
2440122
2440123
2440124
2440125
2440126
2440127
2440128
2440129
2440130
2440131
2440132
2440133
2440134
2440135
2440136
2440137
2440139
2440140
2440142
40471_at
5824
7921571
A_23_P160188
A_24_P19752
GE80865
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005777
GO:0005778
GO:0005829
GO:0006457
GO:0006625
GO:0006886
GO:0007031
GO:0016020
GO:0016557
GO:0016559
GO:0031526
GO:0032991
GO:0033328
GO:0036105
GO:0043226
GO:0045046
GO:0050821
GO:0051117
GO:0061077
GO:0072663
GO:0140104
GO:0140597
GO:1900131
HMNXSV003023092
ILMN_1658759
PH_hs_0025832
TC01005889.hg
TC01006278.hg
X75535_at
g12653448_3p_a_at
g4506338_3p_at
Participates
as an output of
PEX16:PEX19:Pex3 dissociates (Homo sapiens)
PEX16:PEX19:PEX3 dissociates (Homo sapiens)
PEX3:PEX19:class I PMP dissociates (Homo sapiens)
PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)
as an input of
PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)
PEX19 binds Pex3 (Homo sapiens)
PEX19 binds PEX3 (Homo sapiens)
as a component of
PEX19:class I PMP [cytosol] (Homo sapiens)
PEX19:Pex3 [cytosol] (Homo sapiens)
PEX19:PEX3 [cytosol] (Homo sapiens)
PEX19:ABCD1/2/3 [cytosol] (Homo sapiens)
Inferred To
Pex19 [cytosol]
(Drosophila melanogaster)
Pex19 [cytosol]
(Mus musculus)
Pex19 [cytosol]
(Rattus norvegicus)
prx-19 [cytosol]
(Caenorhabditis elegans)
pex19 [cytosol]
(Danio rerio)
pex19 [cytosol]
(Dictyostelium discoideum)
pex19 [cytosol]
(Xenopus tropicalis)
PEX19 [cytosol]
(Bos taurus)
PEX19 [cytosol]
(Canis familiaris)
PEX19 [cytosol]
(Gallus gallus)
PEX19 [cytosol]
(Saccharomyces cerevisiae)
PEX19 [cytosol]
(Schizosaccharomyces pombe)
PEX19 [cytosol]
(Sus scrofa)
Modified Residues
Name
S-farnesyl-L-cysteine at 296
Coordinate
296
PsiMod Name
S-farnesyl-L-cysteine [MOD:00111]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.
Cross References
RefSeq
NP_001180573.1
,
NP_002848.1
OpenTargets
ENSG00000162735
ENSEMBL
ENST00000472750
,
ENST00000368072
,
ENSP00000357051
,
ENSP00000434633
HPA
ENSG00000162735-PEX19
PRO
P40855
Pharos - Targets
P40855
GlyGen
P40855
Orphanet
PEX19
PDB
5LNF
,
3AJB
,
3MK4
,
2W85
,
2WL8
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56589 PEX3
2
PEX3 [cytosol]
(R-HSA-9603792)
PEX3 [peroxisomal membrane]
(R-HSA-382608)
0.982
60
UniProt:O96011 PEX11B
2
PEX11B [peroxisomal membrane]
(R-HSA-9625561)
PEX11B [cytosol]
(R-HSA-9625562)
0.955
31
UniProt:O75381 PEX14
2
PEX14 [cytosol]
(R-HSA-9603806)
PEX14 [peroxisomal membrane]
(R-HSA-9033101)
0.952
31
UniProt:Q9Y5Y5 PEX16
2
PEX16 [peroxisomal membrane]
(R-HSA-9603805)
PEX16 [cytosol]
(R-HSA-9603790)
0.949
29
UniProt:Q9NR77 PXMP2
2
PXMP2 [cytosol]
(R-HSA-9603794)
PXMP2 [peroxisomal membrane]
(R-HSA-8953432)
0.77
5
UniProt:Q9NPF7 IL23A
2
IL23A [endoplasmic reticulum lumen]
(R-HSA-8950224)
IL23A [extracellular region]
(R-HSA-447245)
0.718
6
UniProt:P23284 PPIB
2
PPIB [endoplasmic reticulum lumen]
(R-HSA-1980262)
PPIB [cytosol]
(R-HSA-9728770)
0.718
6
UniProt:O43808 SLC25A17
2
SLC25A17 [cytosol]
(R-HSA-9603781)
SLC25A17 [peroxisomal membrane]
(R-HSA-389642)
0.713
4
UniProt:Q92968 PEX13
2
PEX13 [cytosol]
(R-HSA-9603795)
PEX13 [peroxisomal membrane]
(R-HSA-452790)
0.709
12
UniProt:Q7Z412 PEX26
2
PEX26 [cytosol]
(R-HSA-9603779)
PEX26 [peroxisomal membrane]
(R-HSA-9033092)
0.683
9
UniProt:P28288 ABCD3
2
ABCD3 [cytosol]
(R-HSA-1456459)
ABCD3 [peroxisomal membrane]
(R-HSA-1456468)
0.682
4
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.643
4
UniProt:P28328 PEX2
2
PEX2 [cytosol]
(R-HSA-9625570)
PEX2 [peroxisomal membrane]
(R-HSA-8953913)
0.59
4
UniProt:Q8N9F0 NAT8L
1
NAT8L [mitochondrial matrix]
(R-HSA-8954477)
0.556
3
UniProt:Q99757 TXN2
2
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.556
3
UniProt:P01574 IFNB1
1
IFNB1 [extracellular region]
(R-HSA-877351)
0.556
3
UniProt:O43521 BCL2L11
7
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.556
3
UniProt:Q9UIG4 PS1C2
0.556
5
UniProt:Q3E842 YM122
0.556
3
UniProt:Q9Y680 FKBP7
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:Q6P1Q0 LTMD1
0.527
3
UniProt:P62341 SELT
0.527
2
UniProt:Q8N2A8 PLD6
2
PLD6 [endoplasmic reticulum membrane]
(R-HSA-1498811)
PLD6 [mitochondrial outer membrane]
(R-HSA-5601898)
0.527
2
UniProt:Q8TBP5 F174A
0.527
4
UniProt:Q8IW92 GLB1L2
1
GLB1L2 [lysosomal lumen]
(R-HSA-9840308)
0.527
2
UniProt:Q8IZT6 ASPM
0.527
4
UniProt:Q8N7X8 SIGL1
0.527
2
UniProt:Q9ULX7 CA14
1
CA14 [plasma membrane]
(R-HSA-1237018)
0.527
3
UniProt:O75063 XYLK
0.527
2
UniProt:Q86YD1 PTOV1
0.527
3
UniProt:Q9ULV0 MYO5B
1
MYO5B [cytoplasmic vesicle membrane]
(R-HSA-2028712)
0.527
2
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
3
UniProt:Q8WUY8 NAT14
0.527
4
UniProt:Q9BQ75 CMS1
0.527
2
UniProt:Q9BYC9 MRPL20
1
MRPL20 [mitochondrial inner membrane]
(R-HSA-5368243)
0.527
4
UniProt:Q9NQX4 MYO5C
0.527
3
UniProt:Q10471 GALNT2
2
GALNT2(1-571) [endoplasmic reticulum membrane]
(R-HSA-8849322)
GALNT2(1-571) [Golgi membrane]
(R-HSA-913618)
0.527
4
UniProt:P20138 CD33
3
CD33 [tertiary granule membrane]
(R-HSA-6800959)
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
0.527
2
UniProt:Q6IPU0 CENPP
2
CENPP [nucleoplasm]
(R-HSA-606341)
CENPP [cytosol]
(R-HSA-375299)
0.527
3
UniProt:Q96NR8 RDH12
6
RDH12 A126V [photoreceptor inner segment membrane]
(R-HSA-2471753)
RDH12 Q189* [photoreceptor inner segment membrane]
(R-HSA-2471667)
RDH12 Y226C [photoreceptor inner segment membrane]
(R-HSA-2471697)
RDH12 H151N [photoreceptor inner segment membrane]
(R-HSA-2471751)
RDH12 Ala269Glyfs*2 [photoreceptor inner segment membrane]
(R-HSA-2471748)
RDH12 [photoreceptor inner segment membrane]
(R-HSA-2464787)
0.527
2
UniProt:Q6P1S2 CC033
0.527
3
UniProt:Q16394 EXT1
6
EXT1 R339L [Golgi membrane]
(R-HSA-3730912)
EXT1 L490Rfs*9 [Golgi membrane]
(R-HSA-3730975)
EXT1 R340C [Golgi membrane]
(R-HSA-3730974)
EXT1 G339D [Golgi membrane]
(R-HSA-3730910)
EXT1 G198Afs*54 [Golgi membrane]
(R-HSA-3730971)
EXT1 [Golgi membrane]
(R-HSA-2022897)
0.527
2
UniProt:Q9Y2C4 EXOG
1
EXOG [mitochondrial matrix]
(R-HSA-9914864)
0.527
4
UniProt:Q86VI3 IQGAP3
1
IQGAP3 [cytosol]
(R-HSA-5625977)
0.527
3
UniProt:Q9NXS2 QPCTL
0.527
2
UniProt:Q96L58 B3GALT6
11
B3GALT6 P67L [Golgi membrane]
(R-HSA-4420348)
B3GALT6 D207H [Golgi membrane]
(R-HSA-4420350)
B3GALT6 D118Afs*160 [Golgi membrane]
(R-HSA-4420334)
B3GALT6 C300S [Golgi membrane]
(R-HSA-4420366)
B3GALT6 D156N [Golgi membrane]
(R-HSA-4420367)
B3GALT6 R232C [Golgi membrane]
(R-HSA-4420361)
B3GALT6 R197Afs*81 [Golgi membrane]
(R-HSA-4420356)
B3GALT6 M1? [Golgi membrane]
(R-HSA-4420341)
B3GALT6 S65G [Golgi membrane]
(R-HSA-4420368)
B3GALT6 G217S [Golgi membrane]
(R-HSA-4420322)
B3GALT6 [Golgi membrane]
(R-HSA-913714)
0.527
2
UniProt:Q10469 MGAT2
6
MGAT2 C339* [Golgi membrane]
(R-HSA-4839829)
MGAT2 N318D [Golgi membrane]
(R-HSA-4839827)
MGAT2 S290F [Golgi membrane]
(R-HSA-4839804)
MGAT2 H262R [Golgi membrane]
(R-HSA-4839821)
MGAT2 K237N [Golgi membrane]
(R-HSA-4839784)
MGAT2 [Golgi membrane]
(R-HSA-975830)
0.527
4
UniProt:Q86X52 CHSY1
5
CHSY1 P539R [Golgi membrane]
(R-HSA-3636862)
CHSY1 E33Sfs*2 [Golgi membrane]
(R-HSA-3636864)
CHSY1 Q69* [Golgi membrane]
(R-HSA-3636838)
CHSY1 G19_L28del [Golgi membrane]
(R-HSA-3636823)
CHSY1 [Golgi membrane]
(R-HSA-1971431)
0.527
2
UniProt:O94923 GLCE
1
GLCE [Golgi membrane]
(R-HSA-2024106)
0.527
3
UniProt:P07919 UQCRH
1
UQCRH [mitochondrial inner membrane]
(R-HSA-164286)
0.527
4
UniProt:Q7LGA3 HS2ST1
1
HS2ST1 [Golgi membrane]
(R-HSA-2076393)
0.527
3
UniProt:Q96K12 FAR2
1
FAR2 [peroxisomal membrane]
(R-HSA-390430)
0.527
4
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.527
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.527
2
UniProt:Q9BW72 HIGD2A
1
HIGD2A [mitochondrial inner membrane]
(R-HSA-9865687)
0.527
3
UniProt:Q9NQE9 HINT3
0.527
3
UniProt:O00623 PEX12
2
PEX12 [cytosol]
(R-HSA-9603782)
PEX12 [peroxisomal membrane]
(R-HSA-8953911)
0.527
2
UniProt:P08574 CYC1
3
CYC1(1-325) [mitochondrial intermembrane space]
(R-HSA-1267962)
CYC1(1-325) [cytosol]
(R-HSA-1267995)
CYC1 [mitochondrial inner membrane]
(R-HSA-164277)
0.527
4
UniProt:Q9NVH0 EXD2
0.527
4
UniProt:Q8NHP6 MOSPD2
3
MOSPD2 [endosome membrane]
(R-HSA-9715095)
MOSPD2 [plasma membrane]
(R-HSA-6806308)
MOSPD2 [specific granule membrane]
(R-HSA-6799635)
0.527
4
UniProt:Q9H741 SPRNG
0.527
2
UniProt:Q969V5 MUL1
2
PolyUb-MUL1 [mitochondrial outer membrane]
(R-HSA-6783184)
MUL1 [mitochondrial outer membrane]
(R-HSA-2993772)
0.527
4
UniProt:Q8NBX0 SCCPDH
2
SCCPDH [extracellular region]
(R-HSA-8862997)
SCCPDH [platelet alpha granule lumen]
(R-HSA-8862982)
0.527
4
UniProt:Q86VU5 CMTD1
0.527
5
UniProt:Q9NS84 CHST7
1
CHST7 [Golgi membrane]
(R-HSA-1971545)
0.527
2
UniProt:O94832 MYO1D
0.527
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
4
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