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p-S465,S467-SMAD2 [cytosol]
Stable Identifier
R-HSA-3009186
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-2S-SMAD2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD4 in Cancer (Homo sapiens)
SMAD4 MH2 Domain Mutants in Cancer (Homo sapiens)
SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Homo sapiens)
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-S465,S467-SMAD2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15796 SMAD2
Gene Names
SMAD2, MADH2, MADR2
Chain
initiator methionine:, chain:2-467
Reference Genes
BioGPS Gene:4087 SMAD2
COSMIC (genes):SMAD2 SMAD2
CTD Gene:4087 SMAD2
dbSNP Gene:4087 SMAD2
ENSEMBL:ENSG00000175387 SMAD2
ENSEMBL_homo_sapiens_GENE:ENSG00000175387.16 SMAD2
HGNC:6768 SMAD2
KEGG Gene (Homo sapiens):4087 SMAD2
Monarch:4087 SMAD2
NCBI Gene:4087 SMAD2
OMIM:601366 SMAD2
UCSC:Q15796 SMAD2
Reference Transcript
RefSeq:XM_017025745.1 SMAD2
RefSeq:XM_006722451.3 SMAD2
RefSeq:XM_005258259.3 SMAD2
RefSeq:NM_005901.5 SMAD2
RefSeq:XM_017025746.1 SMAD2
RefSeq:NM_001003652.3 SMAD2
Other Identifiers
11729653_a_at
11729654_a_at
11729655_a_at
11729656_s_at
11734014_a_at
11734015_a_at
11746820_a_at
1453_at
16855090
16855093
1928_s_at
203075_PM_at
203075_at
203076_PM_s_at
203076_s_at
203077_PM_s_at
203077_s_at
226563_PM_at
226563_at
235598_PM_at
235598_at
239271_PM_at
239271_at
3096426
3806892
3806894
3806896
3806898
3806900
3806902
3806904
3806906
3806907
3806908
3806909
3806910
3806911
3806912
3806914
3806915
3806916
3806917
3806918
3806919
3806924
3806926
3806928
3806929
3806931
3806933
3806937
3806938
3806939
3806946
3806947
3806948
3806956
3806957
3806958
3806959
3806960
3806961
4087
50764_at
53730_at
57493_at
70271_at
8023191
8023195
81545_at
90267_at
A_19_P00331466
A_19_P00811827
A_21_P0009555
A_23_P15937
A_24_P202527
A_32_P109002
A_32_P12580
GE59354
GE846664
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003140
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007179
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008285
GO:0009653
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010628
GO:0010629
GO:0010718
GO:0017015
GO:0019902
GO:0023019
GO:0023052
GO:0030073
GO:0030154
GO:0030324
GO:0030325
GO:0030513
GO:0031016
GO:0031047
GO:0031053
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0051098
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071142
GO:0071144
GO:0071333
GO:0071560
GO:0071895
GO:0097718
GO:0140110
GO:0140297
HMNXSV003021861
HMNXSV003023211
HMNXSV003024357
Hs.110741.0.A1_3p_at
Hs.12253.0.A1_3p_at
Hs.204129.0.A1_3p_at
Hs.82483.0.A3_3p_at
ILMN_1751036
ILMN_1754521
ILMN_1771203
PH_hs_0020771
PH_hs_0022288
PH_hs_0033969
PH_hs_0038510
TC18000496.hg
TC18000918.hg
TC18000919.hg
U68018_at
g1575529_3p_a_at
g5174510_3p_a_at
p20421
Participates
as a member of
p-2S-SMAD2,3 [cytosol] (Homo sapiens)
as a component of
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Homo sapiens)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Homo sapiens)
Other forms of this molecule
Ub-SMAD2 [cytosol]
p-S465,S467-SMAD2 P305L [cytosol]
p-S465,S467-SMAD2 D300A [cytosol]
p-S465,S467-SMAD2 D300N [cytosol]
p-S465,S467-SMAD2 A354T [cytosol]
p-S465,S467-SMAD2 P305Q [cytosol]
p-S465,S467-SMAD2 D300V [cytosol]
SMAD2 S464* [cytosol]
SMAD2 W422* [cytosol]
SMAD2 S308* [cytosol]
SMAD2 R427* [cytosol]
SMAD2 W448* [cytosol]
SMAD2 S464L [cytosol]
SMAD2 C463* [cytosol]
SMAD2 R321* [cytosol]
SMAD2 S296* [cytosol]
SMAD2 S306* [cytosol]
SMAD2 Q455* [cytosol]
SMAD2 E439* [cytosol]
SMAD2 L315* [cytosol]
SMAD2 S467P [cytosol]
SMAD2 Q429* [cytosol]
p-S250-SMAD2 [cytosol]
SMAD2 [nucleoplasm]
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
p-T220,S465,S467-SMAD2 [nucleoplasm]
SMAD2 [cytosol]
p-S465,S467-SMAD2 [nucleoplasm]
Inferred To
Homologues of p-S465,S467-SMAD2 [cytosol]
(Gallus gallus)
phospho-MADH2 [cytosol]
(Gallus gallus)
phospho-LOC769000 [cytosol]
(Gallus gallus)
phospho-Smox [cytosol]
(Drosophila melanogaster)
phospho-SMAD2 [cytosol]
(Bos taurus)
phospho-SMAD2 [cytosol]
(Canis familiaris)
phospho-SMAD2 [cytosol]
(Sus scrofa)
phospho-p-S465,S467-SMAD2 [cytosol]
(Danio rerio)
phospho-p-S465,S467-SMAD2 [cytosol]
(Mus musculus)
phospho-p-S465,S467-SMAD2 [cytosol]
(Rattus norvegicus)
phospho-smad2 [cytosol]
(Xenopus tropicalis)
phospho-daf-8 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016881235.1
,
NP_001003652.1
,
XP_005258316.1
,
XP_006722514.1
,
NP_005892.1
,
XP_016881234.1
OpenTargets
ENSG00000175387
HPA
ENSG00000175387-SMAD2
GeneCards
Q15796
Ensembl
ENSG00000175387
,
ENST00000402690
,
ENSP00000349282
,
ENSP00000384449
,
ENST00000262160
,
ENSP00000466193
,
ENST00000356825
,
ENSP00000262160
,
ENST00000586040
PRO
Q15796
Pharos - Targets
Q15796
Orphanet
24927
HMDB Protein
HMDBP14506
PDB
1U7V
,
5XOD
,
6ZVQ
,
5ZOJ
,
1DEV
,
2LB3
,
1KHX
,
6YIA
,
7CO1
,
6M64
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.965
24
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.865
11
UniProt:O95405 ZFYVE9
0.832
8
UniProt:Q9HAU4 SMURF2
2
SMURF2 [nucleoplasm]
(R-HSA-178202)
SMURF2 [cytosol]
(R-HSA-173537)
0.811
6
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.678
3
UniProt:O75593 FOXH1
1
FOXH1 [nucleoplasm]
(R-HSA-1225914)
0.675
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.674
7
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.662
6
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.656
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.646
3
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.589
3
UniProt:Q9BZ29 DOCK9
1
DOCK9 [cytosol]
(R-HSA-1012981)
0.576
3
UniProt:Q12955 ANK3
1
ANK3 [cytosol]
(R-HSA-374562)
0.573
2
UniProt:Q9Y2U8 LEMD3
4
LEMD3 [endosome membrane]
(R-HSA-9715091)
LEMD3 [endoplasmic reticulum membrane]
(R-HSA-9714458)
LEMD3 [plasma membrane]
(R-HSA-9715186)
LEMD3 [nuclear envelope]
(R-HSA-2993886)
0.564
3
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.564
3
UniProt:P12757 SKIL
1
SKIL [nucleoplasm]
(R-HSA-2186596)
0.547
3
UniProt:O15198 SMAD9
3
SMAD9 [cytosol]
(R-HSA-201478)
p-S465,S467-SMAD9 [nucleoplasm]
(R-HSA-201474)
p-S465,S467-SMAD9 [cytosol]
(R-HSA-201441)
0.547
2
UniProt:P35813 PPM1A
2
PPM1A [cytosol]
(R-HSA-380928)
PPM1A [nucleoplasm]
(R-HSA-205813)
0.544
2
UniProt:P12757-1 SKIL
0.536
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
2
UniProt:P61586 RHOA
6
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.524
2
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.524
2
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.524
2
UniProt:P98082 DAB2
3
DAB2 [cytosol]
(R-HSA-8862456)
DAB2 [lysosomal membrane]
(R-HSA-2980807)
DAB2 [plasma membrane]
(R-HSA-2980808)
0.524
4
UniProt:P70056 FOXH1
0.499
4
UniProt:P36801 VE6
0.488
2
UniProt:P10070 GLI2
11
ub-2p-GLI2 [nucleoplasm]
(R-HSA-5635059)
p4S-GLI2 [ciliary base]
(R-HSA-5610487)
p8S-GLI2 [ciliary base]
(R-HSA-5610494)
p11S-GLI2 [ciliary base]
(R-HSA-5610471)
GLI2 [ciliary tip]
(R-HSA-5610363)
GLI2 [ciliary base]
(R-HSA-5610361)
2p-GLI2 [nucleoplasm]
(R-HSA-5635055)
p-GLI2 [nucleoplasm]
(R-HSA-5635047)
p-GLI2 [ciliary tip]
(R-HSA-5635044)
GLI2 [cytosol]
(R-HSA-445451)
ub-p11S-GLI2 [ciliary base]
(R-HSA-5610501)
0.462
2
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