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p-SUPT5H [nucleoplasm]
Stable Identifier
R-HSA-3009372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription elongation factor SPT5, SPT5H_HUMAN, SUPT5H
Locations in the PathwayBrowser for interactor UniProt:Q8N7H5 PAF1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Formation of DSIF complex (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
mRNA Capping (Homo sapiens)
Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00267 SUPT5H
Gene Names
SUPT5H, SPT5, SPT5H
Chain
chain:1-1087
Reference Genes
BioGPS Gene:6829 SUPT5H
COSMIC (genes):SUPT5H SUPT5H
CTD Gene:6829 SUPT5H
dbSNP Gene:6829 SUPT5H
ENSEMBL:ENSG00000196235 SUPT5H
HGNC:11469 SUPT5H
KEGG:hsa:6829 SUPT5H
Monarch:6829 SUPT5H
NCBI Gene:6829 SUPT5H
OMIM:602102 SUPT5H
UCSC:O00267 SUPT5H
Reference Transcript
RefSeq:NM_001319991.1 SUPT5H
RefSeq:NM_001319990.1 SUPT5H
RefSeq:NM_003169.3 SUPT5H
RefSeq:NM_001111020.2 SUPT5H
RefSeq:NM_001130824.1 SUPT5H
RefSeq:NM_001130825.1 SUPT5H
Other Identifiers
11729212_a_at
11763037_at
11763038_x_at
16862029
16862033
201480_PM_s_at
201480_s_at
3250677
35826_at
3833039
3833043
3833044
3833045
3833046
3833047
3833049
3833050
3833051
3833052
3833053
3833054
3833055
3833056
3833057
3833058
3833059
3833060
3833061
3833064
3833065
3833066
3833067
3833068
3833069
3833070
3833071
3833072
3833073
3833074
3833075
3833076
3833077
3833078
3833079
3833080
3833082
3833083
3833084
3833085
3833086
3833087
3833088
3833089
3833090
3833091
3833092
6829
68953_at
74385_s_at
8028674
A_14_P131369
A_23_P27840
A_33_P3364776
GE61168
GE63040
GE88466
GO:0000122
GO:0003682
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006354
GO:0006355
GO:0006357
GO:0006368
GO:0016239
GO:0019899
GO:0032044
GO:0032784
GO:0032785
GO:0032786
GO:0034243
GO:0043226
GO:0045944
GO:0046982
GO:0140673
HMNXSV003013447
HMNXSV003038405
HMNXSV003040608
ILMN_1703866
PH_hs_0020631
PH_hs_0033403
TC19000546.hg
TC19000547.hg
U56402_s_at
g4507312_3p_a_at
p25113
Participates
as a component of
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
phospho-DSIF complex [nucleoplasm] (Homo sapiens)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Homo sapiens)
DSIF complex [nucleoplasm] (Homo sapiens)
as an input of
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
Formation of DSIF complex (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
as an output of
Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)
Inferred To
phospho-spt5 [nucleoplasm]
(Dictyostelium discoideum)
phospho-spt5 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-supt5h [nucleoplasm]
(Danio rerio)
phospho-Spt5 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of p-SUPT5H [nucleoplasm]
(Gallus gallus)
Ghost homologue of p-SUPT5H [nucleoplasm]
(Xenopus tropicalis)
phospho-Supt5h [nucleoplasm]
(Rattus norvegicus)
phospho-p-SUPT5H [nucleoplasm]
(Mus musculus)
phospho-p-SUPT5H [nucleoplasm]
(Plasmodium falciparum)
phospho-SPT5 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-spt-5 [nucleoplasm]
(Caenorhabditis elegans)
phospho-SUPT5H [nucleoplasm]
(Bos taurus)
phospho-SUPT5H [nucleoplasm]
(Canis familiaris)
phospho-SUPT5H [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001104490.1
,
NP_001306920.1
,
NP_001124297.1
,
NP_001124296.1
,
NP_001306919.1
,
NP_003160.2
ENSEMBL
ENSP00000352117
,
ENSP00000469090
,
ENST00000599117
,
ENSP00000404029
,
ENST00000359191
,
ENSP00000384505
,
ENSP00000470252
,
ENST00000402194
,
ENST00000432763
,
ENST00000598725
OpenTargets
ENSG00000196235
HPA
ENSG00000196235-SUPT5H
PRO
O00267
Pharos - Targets
O00267
GlyGen
O00267
PDB
5U98
,
8UHG
,
5OIK
,
7OL0
,
8UHD
,
8UHA
,
4L1U
,
2DO3
,
8UIS
,
5OHQ
,
7YCX
,
7UND
,
8W8F
,
3H7H
,
6EQY
,
2E6Z
,
5OHO
,
6TED
,
8UI0
,
7OKY
,
6GMH
,
6ER0
,
2E70
,
7OKX
,
8P4C
,
8W8E
,
8RBX
,
8P4E
,
7UNC
,
8P4F
,
6GML
,
8P4D
,
7PKS
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63272 SUPT4H1
1
SUPT4H1 [nucleoplasm]
(R-HSA-64905)
0.957
16
UniProt:P24928 POLR2A
7
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-S5(CTD)-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S5,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7(CTD)-POLR2A [nucleoplasm]
(R-HSA-6814543)
0.836
6
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.666
4
UniProt:P60510 PPP4C
1
PPP4C [nucleoplasm]
(R-HSA-5687750)
0.643
3
UniProt:P19387 POLR2C
1
POLR2C [nucleoplasm]
(R-HSA-63506)
0.643
3
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.643
3
UniProt:Q2T9T3 RPAB1
0.606
3
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.527
2
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.527
3
UniProt:Q7KZ85 SUPT6H
1
SUPT6H [nucleoplasm]
(R-HSA-8932908)
0.527
2
UniProt:Q8WVC0 LEO1
1
LEO1 [nucleoplasm]
(R-HSA-3322361)
0.527
3
UniProt:P62875 POLR2L
2
POLR2L [cytosol]
(R-HSA-1964467)
POLR2L [nucleoplasm]
(R-HSA-83715)
0.527
2
UniProt:Q96ST2 IWS1
1
IWS1 [nucleoplasm]
(R-HSA-8932911)
0.527
2
UniProt:O15514 POLR2D
1
POLR2D [nucleoplasm]
(R-HSA-63508)
0.527
2
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.527
2
UniProt:P61218 POLR2F
2
POLR2F [cytosol]
(R-HSA-1964441)
POLR2F [nucleoplasm]
(R-HSA-83714)
0.527
2
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.527
2
UniProt:P52435 POLR2J
1
POLR2J [nucleoplasm]
(R-HSA-63531)
0.527
3
UniProt:P36954 POLR2I
1
POLR2I [nucleoplasm]
(R-HSA-63525)
0.527
2
UniProt:Q9NQG5 RPRD1B
1
RPRD1B [nucleoplasm]
(R-HSA-6814894)
0.527
2
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.527
3
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [cytosol]
(R-HSA-173123)
0.508
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:Q9NZN9 AIPL1
0.508
2
UniProt:Q5EP34 Q5EP34
0.499
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q53EZ4 CEP55
0.488
2
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