Reactome | p-SUPT5H [nucleoplasm]

p-SUPT5H [nucleoplasm]

Stable Identifier

R-HSA-3009372

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription elongation factor SPT5, SPT5H_HUMAN, SUPT5H

Locations in the PathwayBrowser for interactor UniProt:Q9NQG5 RPRD1B

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External Reference Information

External Reference

UniProt:O00267 SUPT5H

Gene Names

SUPT5H, SPT5, SPT5H

Chain

chain:1-1087

Reference Genes

BioGPS Gene:6829 SUPT5H

COSMIC (genes):SUPT5H SUPT5H

CTD Gene:6829 SUPT5H

dbSNP Gene:6829 SUPT5H

ENSEMBL:ENSG00000196235 SUPT5H

ENSEMBL_homo_sapiens_GENE:ENSG00000196235.14 SUPT5H

HGNC:11469 SUPT5H

KEGG Gene (Homo sapiens):6829 SUPT5H

Monarch:6829 SUPT5H

NCBI Gene:6829 SUPT5H

OMIM:602102 SUPT5H

UCSC:O00267 SUPT5H

Reference Transcript

Other Identifiers

11729212_a_at

16862029

16862033

201480_PM_s_at

201480_s_at

35826_at

3833043

3833044

3833045

3833046

3833047

3833049

3833050

3833051

3833052

3833056

3833057

3833058

3833059

3833060

3833064

3833065

3833066

3833069

3833070

3833071

3833073

3833074

3833075

3833076

3833078

3833079

3833080

3833082

3833083

3833084

3833085

3833086

3833089

3833090

3833091

3833092

6829

74385_s_at

8028674

A_23_P27840

A_33_P3364776

GE61168

GO:0000122

GO:0003682

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006351

GO:0006354

GO:0006355

GO:0006357

GO:0006368

GO:0006914

GO:0016239

GO:0019899

GO:0032044

GO:0032784

GO:0032785

GO:0032786

GO:0034243

GO:0043226

GO:0045944

GO:0046982

GO:0140673

HMNXSV003013447

HMNXSV003038405

ILMN_1703866

PH_hs_0020631

PH_hs_0033403

TC19000547.hg

U56402_s_at

g4507312_3p_a_at

Participates

as a component of

as an input of

as an output of

Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)

Inferred To

phospho-spt5 [nucleoplasm] (Dictyostelium discoideum)

phospho-spt5 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-supt5h [nucleoplasm] (Danio rerio)

phospho-Spt5 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of p-SUPT5H [nucleoplasm] (Gallus gallus)

Ghost homologue of p-SUPT5H [nucleoplasm] (Xenopus tropicalis)

phospho-Supt5h [nucleoplasm] (Rattus norvegicus)

phospho-p-SUPT5H [nucleoplasm] (Mus musculus)

phospho-p-SUPT5H [nucleoplasm] (Plasmodium falciparum)

phospho-SPT5 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-spt-5 [nucleoplasm] (Caenorhabditis elegans)

phospho-SUPT5H [nucleoplasm] (Bos taurus)

phospho-SUPT5H [nucleoplasm] (Canis familiaris)

phospho-SUPT5H [nucleoplasm] (Sus scrofa)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001124296.1, NP_003160.2, NP_001124297.1, NP_001306920.1, NP_001104490.1, NP_001306919.1

OpenTargets

ENSG00000196235

HPA

ENSG00000196235-SUPT5H

GeneCards

O00267

Ensembl

ENSP00000352117, ENST00000598725, ENSP00000470252, ENSG00000196235, ENST00000599117, ENST00000359191, ENST00000432763, ENSP00000404029, ENST00000402194, ENSP00000469090, ENSP00000384505

PRO

O00267

Pharos - Targets

O00267

Orphanet

24958

PDB

8RBX, 5OHO, 7PKS, 8P4F, 6EQY, 7UNC, 6GMH, 6ER0, 5OHQ, 7OKX, 7UND, 2E70, 6GML, 8P4E, 2E6Z, 3H7H, 4L1U, 5U98, 6TED, 2DO3, 7OKY, 8P4C, 7OL0, 5OIK, 7YCX, 8P4D

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63272 SUPT4H1	1	SUPT4H1 [nucleoplasm] (R-HSA-64905)	0.957	16
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502)	0.836	6
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.666	4
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.643	3
UniProt:P60510 PPP4C	1	PPP4C [nucleoplasm] (R-HSA-5687750)	0.643	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.643	3
UniProt:Q2T9T3 RPAB1			0.606	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.527	3
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	2
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.527	2
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.527	3
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	2
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.527	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.527	2
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.527	2
UniProt:P61218 POLR2F	2	POLR2F [nucleoplasm] (R-HSA-83714) POLR2F [cytosol] (R-HSA-1964441)	0.527	2
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	2
UniProt:Q8WVC0 LEO1	1	LEO1 [nucleoplasm] (R-HSA-3322361)	0.527	3
UniProt:Q96ST2 IWS1	1	IWS1 [nucleoplasm] (R-HSA-8932911)	0.527	2
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	3
UniProt:Q9NZN9 AIPL1			0.508	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [extracellular region] (R-HSA-173646) PPIA [cytosol] (R-HSA-173123)	0.508	2
UniProt:Q5EP34 Q5EP34			0.499	3
UniProt:Q53EZ4 CEP55			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.488	2

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