Reactome | SUMO is transferred from E1 to E2 (UBE2I, UBC9)

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Stable Identifier

R-HSA-3065678

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Click the image above or here to open this pathway in the Pathway Browser

SUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). UBC9 is the only known E2 enzyme for SUMO and on certain substrates such as RanGAP1 may act without the requirement of an E3 ligase.

Literature References

PubMed ID	Title	Journal	Year
20674646	Post-translational modification by SUMO Hay, RT, Hannoun, Z, Jaffray, E, Greenhough, S, Hay, DC	Toxicology	2010
19923268	SUMOylation and deSUMOylation at a glance Dasso, M, Wang, Y	J. Cell. Sci.	2009
20462400	Mechanisms, regulation and consequences of protein SUMOylation Henley, JM, Wilkinson, KA	Biochem. J.	2010
21102611	The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition Gareau, JR, Lima, CD	Nat. Rev. Mol. Cell Biol.	2010