Reactome | LEMD2 [nuclear envelope]

LEMD2 [nuclear envelope]

Stable Identifier

R-HSA-3067329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

LEM2, LEM domain-containing protein 2

Locations in the PathwayBrowser for interactor UniProt:P46098 HTR3A

Expand all

External Reference Information

External Reference

UniProt:Q8NC56 LEMD2

Gene Names

LEMD2

Chain

initiator methionine:1, chain:2-503

Reference Genes

BioGPS Gene:221496 LEMD2

COSMIC (genes):LEMD2 LEMD2

CTD Gene:221496 LEMD2

dbSNP Gene:221496 LEMD2

ENSEMBL:ENSG00000161904 LEMD2

HGNC:21244 LEMD2

KEGG:hsa:221496 LEMD2

Monarch:221496 LEMD2

NCBI Gene:221496 LEMD2

OMIM:616312 LEMD2

UCSC:Q8NC56 LEMD2

Reference Transcript

Other Identifiers

11741576_a_at

11741577_a_at

11743335_s_at

17018309

221496

224980_PM_at

224980_at

2950848

2950849

2950850

2950851

2950852

2950853

2950854

2950855

2950856

2950860

2950861

2950862

2950863

2950864

2950865

2950866

2950867

2950868

2950869

2950870

2950872

2950873

2950874

2950875

2950876

2950877

2950878

2950879

2950880

60869_at

65458_at

8125788

A_24_P305960

GE850145

GE87062

GO:0000785

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005737

GO:0005783

GO:0005819

GO:0005856

GO:0006998

GO:0016020

GO:0022008

GO:0030154

GO:0031965

GO:0034399

GO:0035914

GO:0043226

GO:0043409

GO:0051898

GO:0060914

GO:0061024

GO:0071168

GO:0071763

HMNXSV003021739

Hs.164919.0.S1_3p_at

Hs.164919.0.S1_3p_x_at

ILMN_1680860

PH_hs_0033512

TC06001593.hg

Participates

as a candidate of

EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as an input of

CHMP7 binds LEMD2 (Homo sapiens)

as a component of

Inferred To

SRC1 [nuclear envelope] (Saccharomyces cerevisiae)

Ghost homologue of LEMD2 [nuclear envelope] (Bos taurus)

Ghost homologue of LEMD2 [nuclear envelope] (Caenorhabditis elegans)

Ghost homologue of LEMD2 [nuclear envelope] (Canis familiaris)

Ghost homologue of LEMD2 [nuclear envelope] (Danio rerio)

Ghost homologue of LEMD2 [nuclear envelope] (Drosophila melanogaster)

Ghost homologue of LEMD2 [nuclear envelope] (Gallus gallus)

Ghost homologue of LEMD2 [nuclear envelope] (Mus musculus)

Ghost homologue of LEMD2 [nuclear envelope] (Rattus norvegicus)

Ghost homologue of LEMD2 [nuclear envelope] (Sus scrofa)

Ghost homologue of LEMD2 [nuclear envelope] (Xenopus tropicalis)

lem2 [nuclear envelope] (Schizosaccharomyces pombe)

LEMD2 [nuclear envelope] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001335638.1, NP_001137416.1, NP_851853.1

OpenTargets

ENSG00000161904

ENSEMBL

ENSP00000421704, ENST00000508327, ENST00000293760, ENSG00000161904, ENSP00000293760

HPA

ENSG00000161904-LEMD2

GeneCards

LEMD2

PRO

Q8NC56

Pharos - Targets

Q8NC56

Orphanet

LEMD2

GlyGen

Q8NC56

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum membrane] (R-HSA-5490331) ASPH [endoplasmic reticulum lumen] (R-HSA-9631383)	0.643	4
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.643	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.643	3
UniProt:Q6P5W5 SLC39A4	9	SLC39A4 [plasma membrane] (R-HSA-442399) SLC39A4 1223_1227del [plasma membrane] (R-HSA-5654119) SLC39A4 L549del [plasma membrane] (R-HSA-5654135) SLC39A4 G330D [plasma membrane] (R-HSA-5654117) SLC39A4 P200L [plasma membrane] (R-HSA-5654131) SLC39A4 Q323Qfs*25 [plasma membrane] (R-HSA-5654109) SLC39A4 G512W [plasma membrane] (R-HSA-5654106) SLC39A4 G526R [plasma membrane] (R-HSA-5654120) SLC39A4 R95C [plasma membrane] (R-HSA-5654137)	0.643	4
UniProt:Q96HU1 SGSM3			0.589	2
UniProt:Q9UGM1 CHRNA9	1	CHRNA9 [plasma membrane] (R-HSA-507827)	0.527	2
UniProt:Q4KMQ2 ANO6	3	ANO6 [tertiary granule membrane] (R-HSA-6800903) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [specific granule membrane] (R-HSA-6799509)	0.527	2
UniProt:Q96AQ6 PBIP1			0.527	3
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:O43505 B4GAT1	1	B4GAT1 [Golgi membrane] (R-HSA-916821)	0.527	3
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:P46098 HTR3A	1	HTR3A [plasma membrane] (R-HSA-975301)	0.527	2
UniProt:Q9C0K1 SLC39A8	1	SLC39A8 [plasma membrane] (R-HSA-442328)	0.527	2
UniProt:Q05901 CHRNB3	1	CHRNB3 [plasma membrane] (R-HSA-507823)	0.527	2
UniProt:P11230 ACHB			0.527	2
UniProt:P32297 CHRNA3	1	CHRNA3 [plasma membrane] (R-HSA-507838)	0.527	2
UniProt:Q96HH4 TM169			0.527	2
UniProt:P80370 DLK1	1	DLK1 [plasma membrane] (R-HSA-1604447)	0.527	2
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.491	2

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