Reactome | K63polyUb-PIK3R2 [cytosol]

K63polyUb-PIK3R2 [cytosol]

Stable Identifier

R-HSA-3080554

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-PI3K-p85 beta, K63polyUb-Phosphatidylinositol 3-kinase regulatory beta subunit, K63polyUb-PI3-kinase p85-beta subunit, K63polyUb-PtdIns-3-kinase p85-beta

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - Regulation of signaling by CBL (Homo sapiens)
        
        CBL ubiquitinates PI3K (Homo sapiens)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K alpha [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
        
        K63polyUb-PIK3R2 [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K beta [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
        
        K63polyUb-PIK3R2 [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K delta [cytosol] (Homo sapiens)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
        
        K63polyUb-PIK3R2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00459 PIK3R2

Gene Names

PIK3R2

Chain

chain:1-728

Reference Genes

BioGPS Gene:5296 PIK3R2

COSMIC (genes):PIK3R2 PIK3R2

CTD Gene:5296 PIK3R2

dbSNP Gene:5296 PIK3R2

ENSEMBL:ENSG00000105647.19 PIK3R2

HGNC:8980 PIK3R2

KEGG Gene (Homo sapiens):5296 PIK3R2

Monarch:5296 PIK3R2

NCBI Gene:5296 PIK3R2

OMIM:603157 PIK3R2

UCSC:O00459 PIK3R2

Reference Transcript

RefSeq:NM_005027.3 PIK3R2

Other Identifiers

0004780403

11744004_at

1568629_PM_s_at

1568629_s_at

16859740

207105_PM_s_at

207105_s_at

2826532

34197_at

3824839

3824841

3824842

3824843

3824844

3824846

3824848

3824850

3824851

3824852

3824855

3824856

3824857

3824859

3824860

3824862

3824864

3824865

3824866

3824867

3824868

3824869

3824870

3824871

3824872

3824873

388_at

5296

8026954

A_14_P103501

A_14_P127707

A_14_P133175

A_23_P142361

A_33_P3367855

GE61807

GE880167

GO:0001678

GO:0001784

GO:0002376

GO:0005515

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005925

GO:0005942

GO:0005943

GO:0006351

GO:0006355

GO:0006629

GO:0006886

GO:0006913

GO:0006914

GO:0006955

GO:0007010

GO:0007155

GO:0007165

GO:0008286

GO:0010506

GO:0014065

GO:0015031

GO:0019903

GO:0023052

GO:0030154

GO:0030183

GO:0030217

GO:0030833

GO:0030971

GO:0032869

GO:0032991

GO:0034976

GO:0036312

GO:0042307

GO:0043226

GO:0043409

GO:0043551

GO:0045785

GO:0045944

GO:0046854

GO:0046935

GO:0046982

GO:0048856

GO:0051492

GO:0065003

GO:0072659

GO:0098772

GO:1903076

HMNXSV003008493

Hs2.390523.1.S1_3p_s_at

ILMN_1726565

PH_hs_0012270

PH_hs_0041093

TC19002628.hg

X80907_at

g4826907_3p_a_at

Participates

as a candidate of

K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)

Other forms of this molecule

PIK3R2 [cytosol]

Inferred To

aap-1 [cytosol] (Caenorhabditis elegans)

PIK3R2 [cytosol] (Bos taurus)

PIK3R2 [cytosol] (Gallus gallus)

PIK3R2 [cytosol] (Sus scrofa)

K63polyUb-PIK3R2 [cytosol] (Canis familiaris)

K63polyUb-PIK3R2 [cytosol] (Danio rerio)

Pi3K21B [cytosol] (Drosophila melanogaster)

pik3r2 [cytosol] (Xenopus tropicalis)

Pik3r2 [cytosol] (Mus musculus)

Pik3r2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_005018.1

Guide to Pharmacology - Targets

2504

OpenTargets

ENSG00000105647

GeneCards

O00459

HPA

ENSG00000105647-PIK3R2

Ensembl

ENST00000222254, ENSP00000222254, ENSG00000105647

PRO

O00459

Pharos - Targets

O00459

Orphanet

21205

HMDB Protein

HMDBP03980

PDB

3MTT, 2XS6, 6U28, 6OX7, 3O5Z, 7RNU, 2KT1

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.823	12
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.76	5
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.752	13
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.702	8
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.688	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.621	4
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.59	19
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P49407 ARRB1	5	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.547	2
UniProt:Q06124 PTPN11	4	p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.483	2

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