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K63polyUb-PIK3R2 [cytosol]
Stable Identifier
R-HSA-3080554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-PI3K-p85 beta, K63polyUb-Phosphatidylinositol 3-kinase regulatory beta subunit, K63polyUb-PI3-kinase p85-beta subunit, K63polyUb-PtdIns-3-kinase p85-beta
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-PI3K alpha [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R2 [cytosol] (Homo sapiens)
K63polyUb-PI3K beta [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R2 [cytosol] (Homo sapiens)
K63polyUb-PI3K delta [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00459 PIK3R2
Gene Names
PIK3R2
Chain
chain:1-728
Reference Genes
BioGPS Gene:5296 PIK3R2
COSMIC (genes):PIK3R2 PIK3R2
CTD Gene:5296 PIK3R2
dbSNP Gene:5296 PIK3R2
ENSEMBL:ENSG00000105647 PIK3R2
ENSEMBL:ENSG00000105647.19 PIK3R2
HGNC:8980 PIK3R2
KEGG Gene (Homo sapiens):5296 PIK3R2
Monarch:5296 PIK3R2
NCBI Gene:5296 PIK3R2
OMIM:603157 PIK3R2
UCSC:O00459 PIK3R2
Reference Transcript
RefSeq:NM_005027.3 PIK3R2
Other Identifiers
11744004_at
1568629_PM_s_at
1568629_s_at
16859740
207105_PM_s_at
207105_s_at
2826532
34197_at
3824839
3824841
3824842
3824843
3824844
3824846
3824848
3824850
3824851
3824852
3824855
3824856
3824857
3824859
3824860
3824862
3824864
3824865
3824866
3824867
3824868
3824869
3824870
3824871
3824872
3824873
388_at
5296
8026954
A_14_P103501
A_14_P127707
A_14_P133175
A_23_P142361
A_33_P3367855
GE61807
GE880167
GO:0001678
GO:0001784
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005925
GO:0005942
GO:0005943
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006913
GO:0006914
GO:0006955
GO:0007010
GO:0007155
GO:0007165
GO:0008286
GO:0010506
GO:0014065
GO:0015031
GO:0019903
GO:0023052
GO:0030154
GO:0030183
GO:0030217
GO:0030833
GO:0030971
GO:0032869
GO:0034976
GO:0036312
GO:0042307
GO:0043226
GO:0043409
GO:0043551
GO:0045785
GO:0045944
GO:0046854
GO:0046935
GO:0046982
GO:0048856
GO:0051492
GO:0065003
GO:0072659
GO:0098772
GO:1903076
HMNXSV003008493
Hs2.390523.1.S1_3p_s_at
ILMN_1726565
PH_hs_0012270
PH_hs_0041093
TC19002628.hg
X80907_at
g4826907_3p_a_at
Participates
as a candidate of
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
Other forms of this molecule
PIK3R2 [cytosol]
Inferred To
aap-1 [cytosol]
(Caenorhabditis elegans)
PIK3R2 [cytosol]
(Bos taurus)
PIK3R2 [cytosol]
(Gallus gallus)
K63polyUb-PIK3R2 [cytosol]
(Canis familiaris)
K63polyUb-PIK3R2 [cytosol]
(Danio rerio)
K63polyUb-PIK3R2 [cytosol]
(Sus scrofa)
Pi3K21B [cytosol]
(Drosophila melanogaster)
pik3r2 [cytosol]
(Xenopus tropicalis)
Pik3r2 [cytosol]
(Mus musculus)
Pik3r2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_005018.1
Guide to Pharmacology - Targets
2504
OpenTargets
ENSG00000105647
HPA
ENSG00000105647-PIK3R2
GeneCards
O00459
Ensembl
ENSP00000222254
,
ENSG00000105647
,
ENST00000222254
PRO
O00459
Pharos - Targets
O00459
Orphanet
21205
PDB
6OX7
,
3O5Z
,
7RCH
,
7RNU
,
6U28
,
3MTT
,
2KT1
,
2XS6
HMDB Protein
HMDBP03980
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.823
12
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.76
5
UniProt:P03496 NS
2
NS1 [nucleoplasm]
(R-FLU-169113)
NS1 [cytosol]
(R-FLU-169118)
0.752
13
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.702
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.659
4
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.621
4
UniProt:P10721 KIT
20
KIT C443Y [plasma membrane]
(R-HSA-9680045)
KIT T417_D419delinsY [plasma membrane]
(R-HSA-9680110)
KIT S476I [plasma membrane]
(R-HSA-9680090)
KIT K509I [plasma membrane]
(R-HSA-9680177)
KIT D419A [plasma membrane]
(R-HSA-9680051)
KIT D419del [plasma membrane]
(R-HSA-9680079)
KIT S501_A502dup [plasma membrane]
(R-HSA-9680105)
KIT D419G [plasma membrane]
(R-HSA-9680057)
KIT N505_F508dup [plasma membrane]
(R-HSA-9680085)
KIT C443S [plasma membrane]
(R-HSA-9680038)
KIT D419N [plasma membrane]
(R-HSA-9680071)
KIT S476N [plasma membrane]
(R-HSA-9680097)
KIT D419H [plasma membrane]
(R-HSA-9680066)
KIT V560_L576del [plasma membrane]
(R-HSA-9670336)
KIT Y823N [plasma membrane]
(R-HSA-9669591)
KIT Y823C [plasma membrane]
(R-HSA-9669585)
p6Y-KIT Y823D [plasma membrane]
(R-HSA-9669628)
p7Y-KIT D816V [plasma membrane]
(R-HSA-9669612)
p7Y-KIT K642E [plasma membrane]
(R-HSA-9669596)
p7Y-KIT N822K [plasma membrane]
(R-HSA-9669617)
0.59
19
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P49407 ARRB1
5
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.547
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.527
4
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