Reactome | monoSUMO1-K-STAG2 [nucleoplasm]

monoSUMO1-K-STAG2 [nucleoplasm]

Stable Identifier

R-HSA-3108187

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys STAG2, SA2, Cohesin subunit SA-2, SCC3 homolog 2

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
16810316	Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks Potts, PR, Porteus, MH, Yu, H	EMBO J.	2006

External Reference Information

External Reference

UniProt:Q8N3U4 STAG2

Gene Names

STAG2, SA2

Chain

chain:1-1231

Reference Genes

COSMIC (genes):STAG2 STAG2

dbSNP Gene:10735 STAG2

ENSEMBL:ENSG00000101972 STAG2

Participates

as a component of

SUMOylated Cohesin [nucleoplasm] (Homo sapiens)

Other forms of this molecule

STAG2 [cytosol]

p-STAG2 [chromosome]

p-STAG2 [cytosol]

p-STAG2 [chromosome, centromeric region]

STAG2 [chromosome]

STAG2 [chromosome, centromeric region]

STAG2 [nucleoplasm]

Inferred To

psc3 [nucleoplasm] (Schizosaccharomyces pombe)

stag2b [nucleoplasm] (Danio rerio)

Homologues of monoSUMO1-K-STAG2 [nucleoplasm] (Schizosaccharomyces pombe)

monoSUMO1-K-STAG2 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K-STAG2 [nucleoplasm] (Gallus gallus)

Stag2 [nucleoplasm] (Mus musculus)

Stag2 [nucleoplasm] (Rattus norvegicus)

scc-3 [nucleoplasm] (Caenorhabditis elegans)

IRR1 [nucleoplasm] (Saccharomyces cerevisiae)

STAG2 [nucleoplasm] (Bos taurus)

STAG2 [nucleoplasm] (Sus scrofa)

rec11 [nucleoplasm] (Schizosaccharomyces pombe)

stag2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.966	22
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.922	14
UniProt:Q9CPY3	6	phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) phospho-Cdca5 [chromosome] (R-MMU-2468266) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.643	5
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.577	4

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